Sjögren's syndrome pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
==Overview== | ==Overview== | ||
ُ[[Sjögren's syndrome]] is a chronic [[Autoimmune disease|auto-immune]] disorder that can affect several organ systems. Both genetic and immune factors contribute to the [[pathogenesis]] of the disease. [[Lymphocyte|Lymphocytes]] (primarily CD4+ T-cells) infiltrate the [[lacrimal]] and [[Salivary gland|salivary]] glands and impair their function, hence causing the main characteristic [[Symptom|symptoms]] of the disease- dry mouth ([[keratoconjunctivitis sicca]]) and eyes ([[xerostomia]]). | |||
==Pathophysiology== | ==Pathophysiology== | ||
The pathogenesis of Sjögren's syndrome can be linked to both genetic and nongenetic components <ref name="pmid23846338">{{cite journal| author=Mavragani CP, Nezos A, Moutsopoulos HM| title=New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. | journal=Curr Opin Rheumatol | year= 2013 | volume= 25 | issue= 5 | pages= 623-9 | pmid=23846338 | doi=10.1097/BOR.0b013e328363eaa5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23846338 }} </ref> | The [[pathogenesis]] of [[Sjögren's syndrome]] can be linked to both genetic and nongenetic components <ref name="pmid23846338">{{cite journal| author=Mavragani CP, Nezos A, Moutsopoulos HM| title=New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. | journal=Curr Opin Rheumatol | year= 2013 | volume= 25 | issue= 5 | pages= 623-9 | pmid=23846338 | doi=10.1097/BOR.0b013e328363eaa5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23846338 }} </ref>. | ||
* '''Genetic components:''' | |||
Evidence suggests genes that encode [[Major histocompatibility complex|Major Histocompatibility Complex]] (MHC), particularly [[Human leukocyte antigen|HLA]] genes, play an important role in the disease. | |||
==References== | ==References== | ||
Revision as of 17:37, 28 January 2018
|
Sjögren's syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Sjögren's syndrome pathophysiology On the Web |
|
American Roentgen Ray Society Images of Sjögren's syndrome pathophysiology |
|
Risk calculators and risk factors for Sjögren's syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Overview
ُSjögren's syndrome is a chronic auto-immune disorder that can affect several organ systems. Both genetic and immune factors contribute to the pathogenesis of the disease. Lymphocytes (primarily CD4+ T-cells) infiltrate the lacrimal and salivary glands and impair their function, hence causing the main characteristic symptoms of the disease- dry mouth (keratoconjunctivitis sicca) and eyes (xerostomia).
Pathophysiology
The pathogenesis of Sjögren's syndrome can be linked to both genetic and nongenetic components [1].
- Genetic components:
Evidence suggests genes that encode Major Histocompatibility Complex (MHC), particularly HLA genes, play an important role in the disease.
References
- ↑ Mavragani CP, Nezos A, Moutsopoulos HM (2013). "New advances in the classification, pathogenesis and treatment of Sjogren's syndrome". Curr Opin Rheumatol. 25 (5): 623–9. doi:10.1097/BOR.0b013e328363eaa5. PMID 23846338.