PKNOX1: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
| update_page = yes
'''Homeobox protein PKNOX1''' is a [[protein]] that in humans is encoded by the ''PKNOX1'' [[gene]].<ref name="pmid9479508">{{cite journal | vauthors = Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F | title = PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C | journal = Genomics | volume = 47 | issue = 2 | pages = 323–4 |date=Apr 1998 | pmid = 9479508 | pmc =  | doi = 10.1006/geno.1997.5086 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5316| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PKNOX1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x2n.
| PDB = {{PDB2|1x2n}}
| Name = PBX/knotted 1 homeobox 1
| HGNCid = 9022
| Symbol = PKNOX1
| AltSymbols =; PREP1; pkonx1c
| OMIM = 602100
| ECnumber = 
| Homologene = 3363
| MGIid = 1201409
| GeneAtlas_image1 = PBB_GE_PKNOX1_204195_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PKNOX1_216004_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PKNOX1_221883_at_tn.png
| Function = {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5316
    | Hs_Ensembl = ENSG00000160199
    | Hs_RefseqProtein = NP_932080
    | Hs_RefseqmRNA = NM_197976
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 43267712
    | Hs_GenLoc_end = 43326757
    | Hs_Uniprot = P55347
    | Mm_EntrezGene = 18771
    | Mm_Ensembl = ENSMUSG00000006705
    | Mm_RefseqmRNA = NM_016670
    | Mm_RefseqProtein = NP_057879
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 31293511
    | Mm_GenLoc_end = 31336394
    | Mm_Uniprot = Q7TT01
  }}
}}
'''PBX/knotted 1 homeobox 1''', also known as '''PKNOX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5316| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Allen TD, Zhu YX, Hawley TS, Hawley RG |title=TALE homeoproteins as HOX11-interacting partners in T-cell leukemia. |journal=Leuk. Lymphoma |volume=39 |issue= 3-4 |pages= 241-56 |year= 2001 |pmid= 11342305 |doi=  }}
*{{cite journal  | vauthors=Allen TD, Zhu YX, Hawley TS, Hawley RG |title=TALE homeoproteins as HOX11-interacting partners in T-cell leukemia |journal=Leuk. Lymphoma |volume=39 |issue= 3–4 |pages= 241–56 |year= 2001 |pmid= 11342305 |doi=  10.3109/10428190009065824}}
*{{cite journal | author=Chang CP, Shen WF, Rozenfeld S, ''et al.'' |title=Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 663-74 |year= 1995 |pmid= 7729685 |doi=  }}
*{{cite journal   |vauthors=Chang CP, Shen WF, Rozenfeld S, etal |title=Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins |journal=Genes Dev. |volume=9 |issue= 6 |pages= 663–74 |year= 1995 |pmid= 7729685 |doi=10.1101/gad.9.6.663 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi= }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  }}
*{{cite journal  | author=Phelan ML, Featherstone MS |title=Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8635-43 |year= 1997 |pmid= 9079695 |doi=  }}
*{{cite journal  | vauthors=Phelan ML, Featherstone MS |title=Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8635–43 |year= 1997 |pmid= 9079695 |doi=10.1074/jbc.272.13.8635 }}
*{{cite journal | author=Chen H, Rossier C, Nakamura Y, ''et al.'' |title=Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3. |journal=Genomics |volume=41 |issue= 2 |pages= 193-200 |year= 1997 |pmid= 9143494 |doi= 10.1006/geno.1997.4632 }}
*{{cite journal   |vauthors=Chen H, Rossier C, Nakamura Y, etal |title=Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3 |journal=Genomics |volume=41 |issue= 2 |pages= 193–200 |year= 1997 |pmid= 9143494 |doi= 10.1006/geno.1997.4632 }}
*{{cite journal  | author=LeBrun DP, Matthews BP, Feldman BJ, Cleary ML |title=The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. |journal=Oncogene |volume=15 |issue= 17 |pages= 2059-67 |year= 1997 |pmid= 9366523 |doi= 10.1038/sj.onc.1201367 }}
*{{cite journal  | vauthors=LeBrun DP, Matthews BP, Feldman BJ, Cleary ML |title=The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains |journal=Oncogene |volume=15 |issue= 17 |pages= 2059–67 |year= 1997 |pmid= 9366523 |doi= 10.1038/sj.onc.1201367 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Berthelsen J, Viggiano L, Schulz H, ''et al.'' |title=PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C. |journal=Genomics |volume=47 |issue= 2 |pages= 323-4 |year= 1998 |pmid= 9479508 |doi= 10.1006/geno.1997.5086 }}
*{{cite journal  | vauthors=Berthelsen J, Zappavigna V, Mavilio F, Blasi F |title=Prep1, a novel functional partner of Pbx proteins |journal=EMBO J. |volume=17 |issue= 5 |pages= 1423–33 |year= 1998 |pmid= 9482739 |doi= 10.1093/emboj/17.5.1423  | pmc=1170490 }}
*{{cite journal | author=Berthelsen J, Zappavigna V, Mavilio F, Blasi F |title=Prep1, a novel functional partner of Pbx proteins. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1423-33 |year= 1998 |pmid= 9482739 |doi= 10.1093/emboj/17.5.1423 }}
*{{cite journal   |vauthors=Berthelsen J, Zappavigna V, Ferretti E, etal |title=The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity |journal=EMBO J. |volume=17 |issue= 5 |pages= 1434–45 |year= 1998 |pmid= 9482740 |doi= 10.1093/emboj/17.5.1434  | pmc=1170491 }}
*{{cite journal  | author=Berthelsen J, Zappavigna V, Ferretti E, ''et al.'' |title=The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1434-45 |year= 1998 |pmid= 9482740 |doi= 10.1093/emboj/17.5.1434 }}
*{{cite journal  | vauthors=Green NC, Rambaldi I, Teakles J, Featherstone MS |title=A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1 |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13273–9 |year= 1998 |pmid= 9582372 |doi=10.1074/jbc.273.21.13273  }}
*{{cite journal | author=Green NC, Rambaldi I, Teakles J, Featherstone MS |title=A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13273-9 |year= 1998 |pmid= 9582372 |doi=  }}
*{{cite journal   |vauthors=Berthelsen J, Kilstrup-Nielsen C, Blasi F, etal |title=The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH |journal=Genes Dev. |volume=13 |issue= 8 |pages= 946–53 |year= 1999 |pmid= 10215622 |doi=10.1101/gad.13.8.946  | pmc=316640 }}
*{{cite journal  | author=Berthelsen J, Kilstrup-Nielsen C, Blasi F, ''et al.'' |title=The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. |journal=Genes Dev. |volume=13 |issue= 8 |pages= 946-53 |year= 1999 |pmid= 10215622 |doi=  }}
*{{cite journal  | vauthors=Jacobs Y, Schnabel CA, Cleary ML |title=Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5134–42 |year= 1999 |pmid= 10373562 |doi= | pmc=84356 }}
*{{cite journal | author=Jacobs Y, Schnabel CA, Cleary ML |title=Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5134-42 |year= 1999 |pmid= 10373562 |doi= }}
*{{cite journal   |vauthors=Knoepfler PS, Bergstrom DA, Uetsuki T, etal |title=A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 |journal=Nucleic Acids Res. |volume=27 |issue= 18 |pages= 3752–61 |year= 1999 |pmid= 10471746 |doi=10.1093/nar/27.18.3752  | pmc=148632  }}
*{{cite journal | author=Knoepfler PS, Bergstrom DA, Uetsuki T, ''et al.'' |title=A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. |journal=Nucleic Acids Res. |volume=27 |issue= 18 |pages= 3752-61 |year= 1999 |pmid= 10471746 |doi= }}
*{{cite journal   |vauthors=Hattori M, Fujiyama A, Taylor TD, etal |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal   |vauthors=Kömüves LG, Shen WF, Kwong A, etal |title=Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation |journal=Dev. Dyn. |volume=218 |issue= 4 |pages= 636–47 |year= 2000 |pmid= 10906782 |doi= 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I }}
*{{cite journal  | author=Kömüves LG, Shen WF, Kwong A, ''et al.'' |title=Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation. |journal=Dev. Dyn. |volume=218 |issue= 4 |pages= 636-47 |year= 2000 |pmid= 10906782 |doi= 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Okada Y, Matsuura E, Nagai R, etal |title=PREP1, MEIS1 homolog protein, regulates PF4 gene expression |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 155–9 |year= 2003 |pmid= 12732210 |doi=10.1016/S0006-291X(03)00718-6 }}
*{{cite journal  | author=Okada Y, Matsuura E, Nagai R, ''et al.'' |title=PREP1, MEIS1 homolog protein, regulates PF4 gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 155-9 |year= 2003 |pmid= 12732210 |doi= }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5316}}


== External links ==
== External links ==
* {{MeshName|PKNOX1+protein,+human}}
* {{MeshName|PKNOX1+protein,+human}}


{{gene-21-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-21-stub}}

Latest revision as of 18:13, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein PKNOX1 is a protein that in humans is encoded by the PKNOX1 gene.[1][2]


References

  1. Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (Apr 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics. 47 (2): 323–4. doi:10.1006/geno.1997.5086. PMID 9479508.
  2. "Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.