SLC26A6: Difference between revisions

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{{Infobox_gene}}
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'''Solute carrier family 26 member 6''' is a [[protein]] that in humans is encoded by the ''SLC26A6'' [[gene]].<ref name="pmid11087667">{{cite journal |author1=Lohi H |author2=Kujala M |author3=Kerkela E |author4=Saarialho-Kere U |author5=Kestila M |author6=Kere J | title = Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger | journal = Genomics | volume = 70 | issue = 1 | pages = 102–12 |date=Jan 2001 | pmid = 11087667 | pmc = | doi = 10.1006/geno.2000.6355 }}</ref><ref name="pmid11247665">{{cite journal |author1=Waldegger S |author2=Moschen I |author3=Ramirez A |author4=Smith RJ |author5=Ayadi H |author6=Lang F |author7=Kubisch C | title = Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family | journal = Genomics | volume = 72 | issue = 1 | pages = 43–50 |date=Mar 2001 | pmid = 11247665 | pmc =  | doi = 10.1006/geno.2000.6445 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC26A6 solute carrier family 26, member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65010| accessdate = }}</ref> It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.<ref>{{cite journal|last=Wang|first=Zhaohui|author2=Tong Wang |author3=Snezana Petrovic |author4=Biguang Tuo |author5=Brigitte Riederer |author6=Sharon Barone |author7=John N. Lorenz |author8=Ursula Seidler |author9=Peter S. Aronson |author10=Manoocher Soleimani |title=Renal and intestinal transport defects in Slc26a6-null mice|journal=American Journal of Physiology. Cell Physiology|date=April 2005|volume=288|series=4|pages=C957-C965|doi=10.1152/ajpcell.00505.2004|pmid=15574486|url=http://ajpcell.physiology.org/content/288/4/C957.full}}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 26, member 6
| HGNCid = 14472
| Symbol = SLC26A6
| AltSymbols =; DKFZp586E1422
| OMIM = 610068
| ECnumber = 
| Homologene = 64480
| MGIid = 2159728
| Function = {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008271 |text = secondary active sulfate transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0008272 |text = sulfate transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 65010
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_001035544
    | Hs_RefseqmRNA = NM_001040454
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end =
    | Hs_Uniprot =
    | Mm_EntrezGene = 171429
    | Mm_Ensembl = ENSMUSG00000023259
    | Mm_RefseqmRNA = NM_134420
    | Mm_RefseqProtein = NP_599252
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 108711260
    | Mm_GenLoc_end = 108769781
    | Mm_Uniprot = 
  }}
}}
'''Solute carrier family 26, member 6''', also known as '''SLC26A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC26A6 solute carrier family 26, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65010| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene belongs to the [[Solute carrier family|solute carrier]] 26 family, whose members encode [[anion]] transporter proteins. This particular family member encodes a protein involved in [[Membrane transport protein|transporting]] [[chloride]], [[oxalate]], [[sulfate]] and [[bicarbonate]]. Several alternatively spliced [[Transcription (genetics)|transcript]] variants of this gene, encoding distinct [[isoforms]], have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SLC26A6 solute carrier family 26, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65010| accessdate = }}</ref>
| summary_text = This gene belongs to the [[Solute carrier family|solute carrier]] 26 family, whose members encode [[anion]] transporter proteins. This particular family member encodes a protein involved in [[Membrane transport protein|transporting]] [[chloride]], [[oxalate]], [[sulfate]] and [[bicarbonate]]. Several alternatively spliced [[Transcription (genetics)|transcript]] variants of this gene, encoding distinct [[isoforms]], have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SLC26A6 solute carrier family 26, member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65010| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Markovich D |title=Physiological roles and regulation of mammalian sulfate transporters. |journal=Physiol. Rev. |volume=81 |issue= 4 |pages= 1499-533 |year= 2001 |pmid= 11581495 |doi=  }}
*{{cite journal  | author=Markovich D |title=Physiological roles and regulation of mammalian sulfate transporters. |journal=Physiol. Rev. |volume=81 |issue= 4 |pages= 1499–533 |year= 2001 |pmid= 11581495 |doi=  }}
*{{cite journal | author=Ignatovich O, Tomlinson IM, Popov AV, ''et al.'' |title=Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire. |journal=J. Mol. Biol. |volume=294 |issue= 2 |pages= 457-65 |year= 2000 |pmid= 10610771 |doi= 10.1006/jmbi.1999.3243 }}
*{{cite journal   |vauthors=Ignatovich O, Tomlinson IM, Popov AV, etal |title=Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire. |journal=J. Mol. Biol. |volume=294 |issue= 2 |pages= 457–65 |year= 2000 |pmid= 10610771 |doi= 10.1006/jmbi.1999.3243 }}
*{{cite journal | author=Lohi H, Kujala M, Kerkelä E, ''et al.'' |title=Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. |journal=Genomics |volume=70 |issue= 1 |pages= 102-12 |year= 2001 |pmid= 11087667 |doi= 10.1006/geno.2000.6355 }}
*{{cite journal   |vauthors=Xie Q, Welch R, Mercado A, etal |title=Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 4 |pages= F826–38 |year= 2002 |pmid= 12217875 |doi= 10.1152/ajprenal.00079.2002 }}
*{{cite journal  | author=Waldegger S, Moschen I, Ramirez A, ''et al.'' |title=Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family. |journal=Genomics |volume=72 |issue= 1 |pages= 43-50 |year= 2001 |pmid= 11247665 |doi= 10.1006/geno.2000.6445 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Xie Q, Welch R, Mercado A, ''et al.'' |title=Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 4 |pages= F826-38 |year= 2002 |pmid= 12217875 |doi= 10.1152/ajprenal.00079.2002 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Chernova MN, Jiang L, Friedman DJ, etal |title=Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 8564–80 |year= 2005 |pmid= 15548529 |doi= 10.1074/jbc.M411703200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kujala M, Tienari J, Lohi H, etal |title=SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney. |journal=Nephron Exp. Nephrol. |volume=101 |issue= 2 |pages= e50–8 |year= 2006 |pmid= 15956810 |doi= 10.1159/000086345 }}
*{{cite journal | author=Chernova MN, Jiang L, Friedman DJ, ''et al.'' |title=Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 8564-80 |year= 2005 |pmid= 15548529 |doi= 10.1074/jbc.M411703200 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kujala M, Tienari J, Lohi H, ''et al.'' |title=SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney. |journal=Nephron Exp. Nephrol. |volume=101 |issue= 2 |pages= e50-8 |year= 2006 |pmid= 15956810 |doi= 10.1159/000086345 }}
*{{cite journal   |vauthors=Shcheynikov N, Wang Y, Park M, etal |title=Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. |journal=J. Gen. Physiol. |volume=127 |issue= 5 |pages= 511–24 |year= 2006 |pmid= 16606687 |doi= 10.1085/jgp.200509392 | pmc=2151520 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Shcheynikov N, Wang Y, Park M, ''et al.'' |title=Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. |journal=J. Gen. Physiol. |volume=127 |issue= 5 |pages= 511-24 |year= 2006 |pmid= 16606687 |doi= 10.1085/jgp.200509392 }}
*{{cite journal   |vauthors=Alper SL, Stewart AK, Chernova MN, etal |title=Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. |journal=Novartis Found. Symp. |volume=273 |issue=  |pages= 107–19; discussion 119–25, 261–4 |year= 2007 |pmid= 17120764 |doi=10.1002/0470029579.ch8 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Alper SL, Stewart AK, Chernova MN, ''et al.'' |title=Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. |journal=Novartis Found. Symp. |volume=273 |issue=  |pages= 107-19; discussion 119-25, 261-4 |year= 2007 |pmid= 17120764 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:30, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[1][2][3] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[4]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[3]

See also

References

  1. ↑ Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
  2. ↑ Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
  4. ↑ Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288: C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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