Hyperlipoproteinemia classification: Difference between revisions

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{{Hyperlipoproteinemia}}
{{Hyperlipoproteinemia}}


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==Overview==
Hyperlipoproteinemia can be classified into primary and secondary hyperlipoproteinemia depending on the etiology.  Primary lipoprotein disorders, caused by genetic mutations, can affect mainly the LDL particle, HDL, or more than one lipoprotein at the same time.  In addition, secondary lipoproteinemia include medical conditions that lead to low lipoprotein levels.
 
==Classification==
 
===Etiology===
Shown below is an algorithm depicting the classification of hyperlipoproteinemia into primary and secondary.
 
{{familytree/start |summary=Hyperlipoproteinemia}}
{{familytree | | | | | | | | | | | | | A01 | | | | | | | | A01= '''Hyperlipoproteinemia'''}}
{{familytree | | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|-|-|-|-|.| | | }}
{{familytree | | | | | | | B01 | | | | | | | | | | | | | | B02 | B01= '''Primary'''<br>(Genetic)| B02= '''Secondary'''}}
{{familytree | | | | | | | |!| | | | | | | | | | | | | | | |!| }}
{{familytree | |,|-|-|-|v|-|^|-|v|-|-|-|.| | | | | | | | | C01 | C01= [[Alcohol]] <br> [[Diabetes]] <br> [[Drug]]s <br> [[Liver disease]] <br> [[Obesity]] <br> [[Renal disease]] <br> [[Smoking]] <br> [[Thyroid]]}}
{{familytree | D01 | | D02 | | D03 | | D04 | | | | D01= '''LDL'''| D02= '''Chylomicron Remnants'''| D03= '''Lipoproteins Rich in Triglyceride'''<br> '''(Chylomicrons, VLDL, IDL)'''| D04= '''HDL'''}}
{{familytree | |!| | | |!| | | |!| | | |!| | | | }}
{{familytree | E01 | | E02 | | E03 | | E04 | | | |E01= -Familial hypercholesterolemia <br> -Familial defective apo B 100 <br> -Autosomal dominant hypercholesterolemia (PCSK9) <br> -Autosomal recessive hypercholesterolemia <br> -Familial sistosterolemia <br> -Familial lipoprotein a lipoproteinemia| E02= -Deficiency in hepatic lipase<br> -Type III dysbetalipoproteinemia| E03= -Deficiency in lipoprotein lipase<br> -Deficiency in Apo C-II <br> -Deficiency in Apo A-V <br> -Familial combined hyperlipidemia<br> -Familial hypertriglyceridemia| E04= -Cholesteryl ester transferase protein deficiency }}
{{familytree/end}}
 
===Laboratory Results===
Hyperlipoproteinemia can be classified according to which major [[lipoprotein]] or major lipid affected as detected in blood laboratory tests:
====High Lipoprotein====
* [[High chilomicron remnant]]
* [[High chylomicron]]
* [[High HDL]]
* [[High IDL]]
* [[High LDL]]
* [[High VLDL]]
 
====High Lipid====
* [[High cholesterol|High total cholesterol]]
* [[High triglyceride]]


==References==
==References==

Latest revision as of 19:10, 17 September 2013

Lipoprotein Disorders Main Page

Hyperlipoproteinemia Microchapters

Hypercholesterolemia Patient Information

Hypertriglyceridemia Patient Information

Overview

Classification

Familial hyperchylomicronemia
Familial hypercholesterolemia
Familial combined hyperlipidemia
Dysbetalipoproteinemia
Primary hypertriglyceridemia
Mixed hyperlipoproteinemia

Differential Diagnosis

Screening

ACC/AHA Guideline Recommendations

Summary

Treatment

Major recommendations for statin therapy

Therapeutic response to statin therapy

Blood cholesterol LDL and non-HDL treatment goals

Treatment in heart failure and hemodialysis

Primary prevention

Secondary prevention

Intensity of statin therapy in primary and secondary prevention

Safety Recommendations

Guideline on Lifestyle Management

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hyperlipoproteinemia can be classified into primary and secondary hyperlipoproteinemia depending on the etiology. Primary lipoprotein disorders, caused by genetic mutations, can affect mainly the LDL particle, HDL, or more than one lipoprotein at the same time. In addition, secondary lipoproteinemia include medical conditions that lead to low lipoprotein levels.

Classification

Etiology

Shown below is an algorithm depicting the classification of hyperlipoproteinemia into primary and secondary.

 
 
 
 
 
 
 
 
 
 
 
 
Hyperlipoproteinemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary
(Genetic)
 
 
 
 
 
 
 
 
 
 
 
 
 
Secondary
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Alcohol
Diabetes
Drugs
Liver disease
Obesity
Renal disease
Smoking
Thyroid
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
LDL
 
Chylomicron Remnants
 
Lipoproteins Rich in Triglyceride
(Chylomicrons, VLDL, IDL)
 
HDL
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
-Familial hypercholesterolemia
-Familial defective apo B 100
-Autosomal dominant hypercholesterolemia (PCSK9)
-Autosomal recessive hypercholesterolemia
-Familial sistosterolemia
-Familial lipoprotein a lipoproteinemia
 
-Deficiency in hepatic lipase
-Type III dysbetalipoproteinemia
 
-Deficiency in lipoprotein lipase
-Deficiency in Apo C-II
-Deficiency in Apo A-V
-Familial combined hyperlipidemia
-Familial hypertriglyceridemia
 
-Cholesteryl ester transferase protein deficiency
 
 
 

Laboratory Results

Hyperlipoproteinemia can be classified according to which major lipoprotein or major lipid affected as detected in blood laboratory tests:

High Lipoprotein

High Lipid

References