Non-bacterial thrombotic endocarditis differential diagnosis: Difference between revisions

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[[Non-bacterial thrombotic endocarditis]] must be differentiated from other [[diseases]] that cause a new or changed [[heart murmur]], multiple [[Systemic embolization|systemic emboli]], +/-[[fever]], such as [[infective endocarditis]], [[Valvular Diseases|degenerative valvular disease]], and [[Pulmonary embolism|pulmonary infarction]].
[[Non-bacterial thrombotic endocarditis]] must be differentiated from other [[diseases]] that cause a new or changed [[heart murmur]], multiple [[Systemic embolization|systemic emboli]], +/-[[fever]], such as [[infective endocarditis]], [[Valvular Diseases|degenerative valvular disease]], and [[Pulmonary embolism|pulmonary infarction]].


 
==Differential Diagnosis==
[[Non-bacterial thrombotic endocarditis]] must be differentiated from other [[diseases]] that cause a new or changed [[heart murmur]], multiple [[Systemic embolization|systemic emboli]], +/-[[fever]], such as;<ref name="urlLibman-Sacks Endocarditis Differential Diagnoses">{{cite web |url=https://emedicine.medscape.com/article/155230-differential |title=Libman-Sacks Endocarditis Differential Diagnoses |format= |work= |accessdate=}}</ref><ref name="urlNonbacterial Thrombotic Endocarditis: Clinicopathologic Study of a Necropsy Series | Revista Española de Cardiología (English Edition)">{{cite web |url=https://www.revespcardiol.org/en-nonbacterial-thrombotic-endocarditis-clinicopathologic-study-articulo-13106392 |title=Nonbacterial Thrombotic Endocarditis: Clinicopathologic Study of a Necropsy Series &#124; Revista Española de Cardiología (English Edition) |format= |work= |accessdate=}}</ref><ref name="pmid3548296">{{cite journal |vauthors=Lopez JA, Ross RS, Fishbein MC, Siegel RJ |title=Nonbacterial thrombotic endocarditis: a review |journal=Am. Heart J. |volume=113 |issue=3 |pages=773–84 |date=March 1987 |pmid=3548296 |doi=10.1016/0002-8703(87)90719-8 |url=}}</ref><ref name="pmid15919332">{{cite journal |vauthors=Borowski A, Ghodsizad A, Cohnen M, Gams E |title=Recurrent embolism in the course of marantic endocarditis |journal=Ann. Thorac. Surg. |volume=79 |issue=6 |pages=2145–7 |date=June 2005 |pmid=15919332 |doi=10.1016/j.athoracsur.2003.12.024 |url=}}</ref><ref name="pmid16965557">{{cite journal |vauthors=Aryana A, Esterbrooks DJ, Morris PC |title=Nonbacterial thrombotic endocarditis with recurrent embolic events as manifestation of ovarian neoplasm |journal=J Gen Intern Med |volume=21 |issue=12 |pages=C12–5 |date=December 2006 |pmid=16965557 |pmc=1924740 |doi=10.1111/j.1525-1497.2006.00614.x |url=}}</ref><ref name="pmid11988602">{{cite journal |vauthors=Singhal AB, Topcuoglu MA, Buonanno FS |title=Acute ischemic stroke patterns in infective and nonbacterial thrombotic endocarditis: a diffusion-weighted magnetic resonance imaging study |journal=Stroke |volume=33 |issue=5 |pages=1267–73 |date=May 2002 |pmid=11988602 |doi=10.1161/01.str.0000015029.91577.36 |url=}}</ref>.
*[[Infective endocarditis]],
*[[Valvular Diseases|Degenerative valvular disease]], and
*[[Pulmonary embolism|Pulmonary infarction]].


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Latest revision as of 19:11, 6 August 2020

non-bacterial thrombotic endocarditis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]

Overview

Non-bacterial thrombotic endocarditis must be differentiated from other diseases that cause a new or changed heart murmur, multiple systemic emboli, +/-fever, such as infective endocarditis, degenerative valvular disease, and pulmonary infarction.

Differential Diagnosis

Non-bacterial thrombotic endocarditis must be differentiated from other diseases that cause a new or changed heart murmur, multiple systemic emboli, +/-fever, such as;[1][2][3][4][5][6].

Diseases Diagnostic tests Physical Examination Symptoms Past medical history Other Findings
CT scan and MRI EKG Chest X-ray Tachypnea Tachycardia Fever Chest Pain Hemoptysis Dyspnea on Exertion Wheezing Chest Tenderness Nasalopharyngeal Ulceration Carotid Bruit
Pulmonary embolism
  • On CT angiography:
    • Intra-luminal filling defect
  • On MRI:
    • Narrowing of involved vessel
    • No contrast seen distal to obstruction
    • Polo-mint sign (partial filling defect surrounded by contrast)
✔ (Low grade) ✔ (In case of massive PE) - - - -
Infective Endocarditis
  • Goldberg's criteria may aid in diagnosis of left ventricular dysfunction: (High specificity)
    • SV1 or SV2 + RV5 or RV6 ≥3.5 mV
    • Total QRS amplitude in each of the limb leads ≤0.8 mV
    • R/S ratio <1 in lead V4
- - - - - -
Non-bacterial thrombotic endocarditis
  • ST elevation
  • PR depression
✔ (Low grade) ✔ (Relieved by sitting up and leaning forward) - - - - -
  • May be clinically classified into:
    • Acute (< 6 weeks)
    • Sub-acute (6 weeks - 6 months)
    • Chronic (> 6 months)
Libman Sack Endocarditis - - - -
Vasculitis

Homogeneous, circumferential vessel wall swelling

-
Fever of unknown origin (FUO) - - - - - -

Differentiating [Disease name] from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].


References

  1. "Libman-Sacks Endocarditis Differential Diagnoses".
  2. "Nonbacterial Thrombotic Endocarditis: Clinicopathologic Study of a Necropsy Series | Revista Española de Cardiología (English Edition)".
  3. Lopez JA, Ross RS, Fishbein MC, Siegel RJ (March 1987). "Nonbacterial thrombotic endocarditis: a review". Am. Heart J. 113 (3): 773–84. doi:10.1016/0002-8703(87)90719-8. PMID 3548296.
  4. Borowski A, Ghodsizad A, Cohnen M, Gams E (June 2005). "Recurrent embolism in the course of marantic endocarditis". Ann. Thorac. Surg. 79 (6): 2145–7. doi:10.1016/j.athoracsur.2003.12.024. PMID 15919332.
  5. Aryana A, Esterbrooks DJ, Morris PC (December 2006). "Nonbacterial thrombotic endocarditis with recurrent embolic events as manifestation of ovarian neoplasm". J Gen Intern Med. 21 (12): C12–5. doi:10.1111/j.1525-1497.2006.00614.x. PMC 1924740. PMID 16965557.
  6. Singhal AB, Topcuoglu MA, Buonanno FS (May 2002). "Acute ischemic stroke patterns in infective and nonbacterial thrombotic endocarditis: a diffusion-weighted magnetic resonance imaging study". Stroke. 33 (5): 1267–73. doi:10.1161/01.str.0000015029.91577.36. PMID 11988602.

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