Non-bacterial thrombotic endocarditis history and symptoms
|
non-bacterial thrombotic endocarditis |
|
Differentiating non-bacterial thrombotic endocarditis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Non-bacterial thrombotic endocarditis history and symptoms On the Web |
|
American Roentgen Ray Society Images of Non-bacterial thrombotic endocarditis history and symptoms |
|
FDA on Non-bacterial thrombotic endocarditis history and symptoms |
|
CDC on Non-bacterial thrombotic endocarditis history and symptoms |
|
Non-bacterial thrombotic endocarditis history and symptoms in the news |
|
Blogs on Non-bacterial thrombotic endocarditis history and symptoms |
|
Risk calculators and risk factors for Non-bacterial thrombotic endocarditis history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]
Overview
The majority of patients with non-bacterial thrombotic endocarditis are asymptomatic. Systemic embolism of the brain, liver, or spleen is a common initial clinical manifestation of NBTE, and occur in more than half of patients. Patients with NBTE may have a positive history of malignancy, disseminated intravascular coagulation, antiphospholipid syndrome, autoimmune disease such as systemic lupus erythematosus, e.t.c
History and Symptoms
- The majority of patients with non-bacterial thrombotic endocarditis are asymptomatic[1].
- Systemic embolism of the brain, liver, or spleen is a common initial clinical manifestation of NBTE, and occur in more than half of patients[2][3][4].
- The most common presentation of NBTE is a sudden stroke[5].
- About 50% of patients with NBTE present with new or a change in existing cardiac murmurs.
- Murmurs are usually non-specific systolic murmurs commonly located in the left lower sternal border[6].
- Valvular deficiency or heart failure is an uncommon initial presentation[7].
History
Patients with NBTE may have a positive history of[1][8][9];
- Malignancy
- Disseminated intravascular coagulation
- Antiphospholipid syndrome
- Autoimmune disease such as systemic lupus erythematosus
Common Symptoms
In alphabetical order, some of the common manifestations and symptoms of NTBE include:
- Signs of cerebrovascular embolism i.e[5];
- Amnesia
- Delirium
- Dysphagia
- Dysphasia
- Dysarthria
- Localized/diffuse weakness
- Localized/diffuse numbness
- Psychomotor agitation
- Seizures
- Vision loss
- Signs of heart failure secondary to defective valves i.e[7];
- Chest pain
- Dyspnea
- Lethargy
- Orthopnea
- Paroxysmal nocturnal dyspnea
- Peripheral edema
- Symptoms due to underlying systemic lupus erythematosus[8];
- Arthritis
- Hematuria
- Rash
- Sweating
- Fatigue
- Signs of systemic thromboembolism i.e[10][11][12];
- Acute abdominal syndromes;
- Flank pain due to kidney infarction
- Nausea
- Pain
- Vomiting
- Raynaud's phenomenon due to embolization to the skin
- Acute abdominal syndromes;
Less Common Symptoms
In alphabetical order, some of the less common manifestations and symptoms of NBTE include;
- Secondary infective endocarditis
- Chest pain
- Fever
- Night sweats
- Weightloss
References
- ↑ 1.0 1.1 [+https://doi.org/10.1634/theoncologist.12-5-518 "Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment - el‐Shami - 2007 - The Oncologist - Wiley Online Library"] Check
|url=value (help). - ↑ Edoute Y, Haim N, Rinkevich D, Brenner B, Reisner SA (March 1997). "Cardiac valvular vegetations in cancer patients: a prospective echocardiographic study of 200 patients". Am. J. Med. 102 (3): 252–8. doi:10.1016/S0002-9343(96)00457-3. PMID 9217593.
- ↑ el-Shami K, Griffiths E, Streiff M (May 2007). "Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment". Oncologist. 12 (5): 518–23. doi:10.1634/theoncologist.12-5-518. PMID 17522239.
- ↑ "Infective endocarditis | The BMJ".
- ↑ 5.0 5.1 Graus F, Rogers LR, Posner JB (January 1985). "Cerebrovascular complications in patients with cancer". Medicine (Baltimore). 64 (1): 16–35. doi:10.1097/00005792-198501000-00002. PMID 3965856.
- ↑ Rosen P, Armstrong D (January 1973). "Nonbacterial thrombotic endocarditis in patients with malignant neoplastic diseases". Am. J. Med. 54 (1): 23–9. doi:10.1016/0002-9343(73)90079-x. PMID 4682494.
- ↑ 7.0 7.1 Mazokopakis EE, Syros PK, Starakis IK (June 2010). "Nonbacterial thrombotic endocarditis (marantic endocarditis) in cancer patients". Cardiovasc Hematol Disord Drug Targets. 10 (2): 84–6. doi:10.2174/187152910791292484. PMID 20397972.
- ↑ 8.0 8.1 "Libman-Sacks Endocarditis Clinical Presentation: History, Physical Examination".
- ↑ "Non-bacterial Thrombotic Endocarditis | IntechOpen".
- ↑ Barry WE, Scarpelli D, Nonbacterial thrombotic endocarditis. A clinicopathologic study. Arch Neurol Med. 1962; 109: 79– 84
- ↑ Kooiker JC, MacLean JM, Sumi SM (April 1976). "Cerebral embolism, marantic endocarditis, and cancer". Arch. Neurol. 33 (4): 260–4. doi:10.1001/archneur.1976.00500040044006. PMID 1259640.
- ↑ Miksanek T (April 1983). "Nonbacterial thrombotic endocarditis". Am Fam Physician. 27 (4): 177–9. PMID 6837399.