Non-bacterial thrombotic endocarditis risk factors

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non-bacterial thrombotic endocarditis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]

Overview

The most potent risk factor in the development of non-bacterial thrombotic endocarditis is advanced malignancy. Other risk factors include systemic lupus erythematosus, antiphospholipid syndrome, and chronic inflammatory states.

Risk Factors

The most potent risk factor in the development of non-bacterial thrombotic endocarditis is advanced malignancy[1][2]. Other risk factors include systemic lupus erythematosus, antiphospholipid syndrome [3], and chronic inflammatory states.

Risk factors for the development of Non-bacterial endocarditis[4]
Risk factor Details
Advanced stage malignancy Advanced stage malignancies such as:
  • Mucin-secreting and pancreatic adenocarcinoma[5]
  • Adenocarcinoma of the lung
  • Adenocarcinoma of the ovary
  • Colon carcinoma
  • Cancer of the prostate
  • Cholangiocarcinoma
  • Lymphoma
Systemic autoimmune diseases
  • Systemic lupus erythematosus[6]
  • Antiphospholipid syndrome[7]
  • Systemic vasculitis i.e;
    • Giant cell arteritis
    • Takayasu's arteritis
    • Polyangitis with granulomatosis
Hypercoagulable states
  • Disseminated intravascular coagulation.
  • Protein C and S deficiency
  • Thrombotic micrangiopathy
Chronic inflammatory state
  • Tuberculosis
  • Uncontrolled HIV
  • Chronic pyelonephritis
Others
  • Adenomyosis
  • Heart failure with valvulopathy
  • Chronic renal disease
  • Chronic alcoholism

References

  1. González Quintela A, Candela MJ, Vidal C, Román J, Aramburo P (1991). "Non-bacterial thrombotic endocarditis in cancer patients". Acta Cardiol. 46 (1): 1–9. PMID 1851590.
  2. Rosen P, Armstrong D (January 1973). "Nonbacterial thrombotic endocarditis in patients with malignant neoplastic diseases". Am. J. Med. 54 (1): 23–9. doi:10.1016/0002-9343(73)90079-x. PMID 4682494.
  3. Roldan CA, Qualls CR, Sopko KS, Sibbitt WL Jr. Transthoracic versus transesophageal echocardiography for detection of Libman-Sacks endocarditis: A randomized controlled study. The Journal of Rheumatology. 2008;35:224
  4. "Non-bacterial Thrombotic Endocarditis | IntechOpen".
  5. el-Shami K, Griffiths E, Streiff M (May 2007). "Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment". Oncologist. 12 (5): 518–23. doi:10.1634/theoncologist.12-5-518. PMID 17522239.
  6. Roldan CA, Shively BK, Crawford MH (November 1996). "An echocardiographic study of valvular heart disease associated with systemic lupus erythematosus". N. Engl. J. Med. 335 (19): 1424–30. doi:10.1056/NEJM199611073351903. PMID 8875919.
  7. Roldan CA, Qualls CR, Sopko KS, Sibbitt WL (February 2008). "Transthoracic versus transesophageal echocardiography for detection of Libman-Sacks endocarditis: a randomized controlled study". J. Rheumatol. 35 (2): 224–9. PMID 18085739.

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