Squamous cell carcinoma of the skin: Difference between revisions

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__NOTOC__
{{Squamous cell carcinoma}}
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{DiseaseDisorder infobox |
{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@wikidoc.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:ravitheja.g@gmail.com], {{Faizan}}{{Anum}}
  Name        = Squamous cell carcinoma, NOS |
  Image      = Squamous Cell Carcinoma.jpg |
  Caption    = Tends to arise from pre-malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here). |
  ICD10      = C44 |
  ICD9        = {{ICD9|173}} |
  ICDO        = {{ICDO|8070|3}} |
  MedlinePlus    = 000829 |
}}
{{Squamous cell carcinoma}}
{{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@perfuse.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:rgudetti@perfuse.org]
 
==[[Squamous cell carcinoma overview|Overview]]==
 
==[[Squamous cell carcinoma historical aspects|Historical Aspects]]==
 
==[[Squamous cell carcinoma pathophysiology|Pathophysiology]]==
 
==[[Squamous cell carcinoma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Squamous cell carcinoma risk factors|Risk Factors]]==
 
==[[Squamous cell carcinoma screening|Screening]]==
 
==[[Squamous cell carcinoma causes of squamous cell carcinoma|Causes of Squamous cell carcinoma]]==
 
==[[Squamous cell carcinoma differential diagnosis|Differential Diagnosis]]==
 
==[[Squamous cell carcinoma natural history complications and prognosis|Natural History Complications and Prognosis]]==
 
==[[Squamous cell carcinoma history and symptoms|History & Symptoms]]==
 
==[[Squamous cell carcinoma physical examination|Physical Examination]]==
 
===Esophagus===
 
[[Esophageal cancer]] may be due to either squamous cell carcinoma (ESCC) or [[adenocarcinoma]] (EAC). SCCs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach. [[Dysphagia]] (difficulty swallowing, solids worse than liquids) and [[odynophagia]] are common initial symptoms. If the disease is localized, [[esophagectomy]] may offer the possibility of a cure. If the disease has spread, [[chemotherapy]] and radiotherapy are commonly used.


====Penis====
==[[Squamous cell carcinoma of the skin overview|Overview]]==
When squamous cell carcinoma in situ (Bowen's disease) is found on the penis, it is called erythroplasia of Queyrat<ref>http://www.emedicine.com/derm/TOPIC144.HTM</ref>.  This type of cancer respond very well to an experimental agent called Aldara.


====Prostate====
==[[Squamous cell carcinoma of the skin historical perspective|Historical Perspective]]==
When associated with the prostate, squamous cell carcinoma is very aggressive in nature. It is difficult to detect as there is no increase in [[prostate specific antigen]] levels seen; meaning that the cancer is often diagnosed at an advanced stage.


<div align="left">
==[[Squamous cell carcinoma of the skin classification|Classification]]==
<gallery heights="175" widths="175">
Image:Squamous cell carcinoma of prostate.jpg|Prostate: Squamous cell carcinoma
Image:Squamous cell carcinoma of prostate 2.jpg|Prostate: Squamous cell carcinoma
</gallery>
</div>


====Lung====
==[[Squamous cell carcinoma of the skin pathophysiology|Pathophysiology]]==


When associated with the lung, it often causes ectopic production of [[parathyroid hormone-related protein]] (PTHrP), resulting in [[hypercalcemia]].
==[[Squamous cell carcinoma of the skin causes|Causes]]==


<div align="left">
==[[Squamous cell carcinoma of the skin differential diagnosis|Differenting Squamous cell carcinoma of the skin from other Diseases]]==
<gallery heights="175" widths="175">
Image:Oral cancer (1) squamous cell carcinoma histopathology.jpg|[[Biopsy]] of a highly differentiated squamous cell carcinoma of the mouth. [[H&E stain|Haematoxylin & eosin stain]].
Image:Ca bronchus.jpg|Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus
</gallery>
</div>


====Vagina and cervix====
==[[Squamous cell carcinoma of the skin epidemiology and demographics|Epidemiology and Demographics]]==


Vaginal squamous cell carcinoma spreads slowly and usually stays near the vagina, but may spread to the lungs and liver. This is the most common type of [[vaginal cancer]].
==[[Squamous cell carcinoma of the skin risk factors|Risk Factors]]==


=== Cervix: Squamous cell carcinoma===
==[[Squamous cell carcinoma of the skin screening|Screening]]==


<youtube v=zB47nE-i8dQ/>
==[[Squamous cell carcinoma of the skin natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


==Diagnosis==


<youtube v=J3kULzKGzws/>
[[Squamous cell carcinoma of the skin staging|Staging]] | [[Squamous cell carcinoma of the skin history and symptoms|History and Symptoms]] | [[Squamous cell carcinoma of the skin physical examination|Physical Examination]] | [[Squamous cell carcinoma of the skin laboratory findings|Laboratory Findings]] | [[Squamous cell carcinoma of the skin electrocardiogram|Electrocardiogram]] | [[Squamous cell carcinoma of the skin chest x ray|Chest X Ray]] | [[Squamous cell carcinoma of the skin CT|CT]] | [[Squamous cell carcinoma of the skin MRI|MRI]] | [[Squamous cell carcinoma of the skin echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Squamous cell carcinoma of the skin other imaging findings|Other Imaging Findings]] | [[Squamous cell carcinoma of the skin other diagnostic studies|Other Diagnostic Studies]]


==Treatment==


==[[Squamous cell carcinoma staging|Staging]]==
[[Squamous cell carcinoma of the skin medical therapy|Medical Therapy]] | [[Squamous cell carcinoma of the skin surgery|Surgery]] | [[Squamous cell carcinoma of the skin primary prevention|Primary Prevention]] | [[Squamous cell carcinoma of the skin secondary prevention|Secondary Prevention]] | [[Squamous cell carcinoma of the skin cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Squamous cell carcinoma of the skin future or investigational therapies|Future or Investigational Therapies]]
==[[Squamous cell carcinoma treatment|Treatment]]==


==Case Studies==


*'''[[Squamous cell carcinoma medical treatment|Medical treatment]]'''
[[Squamous cell carcinoma of the skin case study one|Case #1]]
*'''[[Squamous cell carcinoma surgical treatment|Surgical treatment]]'''
*'''[[Primary Prevention]]'''
*'''[[Secondary Prevention''']]
 
==Future and Investigational treatment strategies==
 
In 2007, Australian biopharmaceutical company Clinuvel Pharmaceuticals Limited began [[clinical trials]] with a [[melanocyte-stimulating hormone]] called [[melanotan]]  (known by the [[International Nonproprietary Name]] ''afamelanotide'', formerly CUV1647)<ref name="Clinuvel-INN">{{Cite web|url=http://www.clinuvel.com/resources/pdf/asx_announcements/2008/20080617WHOGenericName.pdf|title=World Health Organisation assigns CUV1647 generic name|accessdate=2008-06-17|publisher=Clinuvel|year=2008|format=[[Portable Document Format|PDF]]}}</ref> to provide [[photoprotection]] for organ transplant patients against squamous cell carcinoma of the skin and [[actinic keratosis]].<ref name="Clinuvel">[http://www.clinuvel.com/en/faqs/ Clinuvel » Investors » FAQs<!-- Bot generated title -->]</ref><ref name="PharmaAsia">[http://www.pharmaasia.com/article-6618-clinuvelsdrugbeginsglobalphaseiiskincancertrials-Asia.html PharmaAsia - Clinuvel’s Drug Begins Global Phase II Skin Cancer Trials]</ref>
 
[[Cetuximab]] a monoclonal antibody that targets the epidermal growth factor receptor (EGFR), has antitumor activity in patients with advanced squamous cell carcinoma of the skin, as initially suggested by case reports.
 
==References==
{{reflist|2}}
 
==External links==
*[http://www.skincancer.org/squamous/index.php Information on Squamous Cell Carcinoma from The Skin Cancer Foundation]
* [http://www.emedicine.com/DERM/topic401.htm Article by Stephen D Hess, MD, PhD]
* [http://www.dermnetnz.org/lesions/squamous-cell-carcinoma.html DermNet NZ: Squamous cell carcinoma]
* [http://www.skintherapyletter.com/2004/9.4/2.html Squamous cell carcinoma in transplant recipients]
 


{{Diseases of the skin and appendages by morphology}}
{{Diseases of the skin and appendages by morphology}}
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[[Category:Otolaryngology]]
[[Category:Otolaryngology]]
[[Category:Mature chapter]]
[[Category:Mature chapter]]
[[Category:Grammar]]


[[de:Plattenepithelkarzinom]]
 
[[he:קרצינומת תאי קשקש]]
[[nl:Plaveiselcelcarcinoom]]
[[pl:Rak kolczystokomórkowy skóry]]
[[tr:Skuamöz hücreli karsinoma]]


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Latest revision as of 15:27, 30 May 2019

Squamous cell carcinoma of the skin Microchapters

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Overview

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Pathophysiology

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Diagnosis

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History and Symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3], Faizan Sheraz, M.D. [4] Anum Gull M.B.B.S.[5]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differenting Squamous cell carcinoma of the skin from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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