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{{ | '''Pre-B-cell leukemia transcription factor 2''' is a [[protein]] that in humans is encoded by the ''PBX2'' [[gene]].<ref name="pmid7835890">{{cite journal | vauthors = Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T | title = Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3 | journal = Genomics | volume = 23 | issue = 2 | pages = 408–19 | date = Sep 1994 | pmid = 7835890 | pmc = | doi = 10.1006/geno.1994.1517 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5089| accessdate = }}</ref> | ||
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== Function == | |||
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.<ref name="entrez" /> | |||
==References== | == Interactions == | ||
{{reflist | |||
==Further reading== | PBX2 has been shown to [[Protein-protein interaction|interact]] with [[HOXA9]].<ref name=pmid10082572>{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 }}</ref> | ||
== References == | |||
{{reflist}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Monica K, Galili N, Nourse J, Saltman D, Cleary ML | title = PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 | journal = Molecular and Cellular Biology | volume = 11 | issue = 12 | pages = 6149–57 | date = Dec 1991 | pmid = 1682799 | pmc = 361792 | doi = 10.1128/mcb.11.12.6149}} | |||
* {{cite journal | vauthors = Aguado B, Campbell RD | title = The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein | journal = Genomics | volume = 25 | issue = 3 | pages = 650–9 | date = Feb 1995 | pmid = 7759099 | doi = 10.1016/0888-7543(95)80007-9 }} | |||
*{{cite journal | * {{cite journal | vauthors = Lu Q, Wright DD, Kamps MP | title = Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation | journal = Molecular and Cellular Biology | volume = 14 | issue = 6 | pages = 3938–48 | date = Jun 1994 | pmid = 7910944 | pmc = 358760 | doi = 10.1128/mcb.14.6.3938}} | ||
*{{cite journal | * {{cite journal | vauthors = Katsanis N, Fitzgibbon J, Fisher EM | title = Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci | journal = Genomics | volume = 35 | issue = 1 | pages = 101–8 | date = Jul 1996 | pmid = 8661110 | doi = 10.1006/geno.1996.0328 }} | ||
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Mavilio F, Blasi F | title = Prep1, a novel functional partner of Pbx proteins | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1423–33 | date = Mar 1998 | pmid = 9482739 | pmc = 1170490 | doi = 10.1093/emboj/17.5.1423 }} | |||
*{{cite journal | * {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T | title = Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes | journal = Experimental Hematology | volume = 29 | issue = 7 | pages = 856–63 | date = Jul 2001 | pmid = 11438208 | doi = 10.1016/S0301-472X(01)00655-5 }} | ||
*{{cite journal | * {{cite journal | vauthors = Brake RL, Kees UR, Watt PM | title = A complex containing PBX2 contributes to activation of the proto-oncogene HOX11 | journal = Biochemical and Biophysical Research Communications | volume = 294 | issue = 1 | pages = 23–34 | date = May 2002 | pmid = 12054735 | doi = 10.1016/S0006-291X(02)00426-6 }} | ||
*{{cite journal | * {{cite journal | vauthors = Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T | title = Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene | journal = Blood | volume = 101 | issue = 12 | pages = 4748–56 | date = Jun 2003 | pmid = 12609849 | doi = 10.1182/blood-2002-02-0380 }} | ||
*{{cite journal | * {{cite journal | vauthors = Longobardi E, Blasi F | title = Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 39235–41 | date = Oct 2003 | pmid = 12871956 | doi = 10.1074/jbc.M304704200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L | title = Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse | journal = Genome Research | volume = 13 | issue = 12 | pages = 2621–36 | date = Dec 2003 | pmid = 14656967 | pmc = 403804 | doi = 10.1101/gr.1736803 }} | ||
*{{cite journal | * {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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* {{MeshName|PBX2+protein,+human}} | * {{MeshName|PBX2+protein,+human}} | ||
{{PDB Gallery|geneid=5089}} | |||
{{Transcription factors|g2}} | |||
{{NLM content}} | {{NLM content}} | ||
{{ | {{gene-6-stub}} | ||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
Latest revision as of 17:38, 7 September 2017
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Location (UCSC) | n/a | n/a | |||||
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Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[1][2]
Function
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[2]
Interactions
PBX2 has been shown to interact with HOXA9.[3]
References
- ↑ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
- ↑ 2.0 2.1 "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".
- ↑ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099. PMID 10082572.
Further reading
- Monica K, Galili N, Nourse J, Saltman D, Cleary ML (Dec 1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Molecular and Cellular Biology. 11 (12): 6149–57. doi:10.1128/mcb.11.12.6149. PMC 361792. PMID 1682799.
- Aguado B, Campbell RD (Feb 1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics. 25 (3): 650–9. doi:10.1016/0888-7543(95)80007-9. PMID 7759099.
- Lu Q, Wright DD, Kamps MP (Jun 1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Molecular and Cellular Biology. 14 (6): 3938–48. doi:10.1128/mcb.14.6.3938. PMC 358760. PMID 7910944.
- Katsanis N, Fitzgibbon J, Fisher EM (Jul 1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics. 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.
- Berthelsen J, Zappavigna V, Mavilio F, Blasi F (Mar 1998). "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMC 1170490. PMID 9482739.
- Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099. PMID 10082572.
- Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T (Jul 2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
- Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
- Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.
- Longobardi E, Blasi F (Oct 2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". The Journal of Biological Chemistry. 278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID 12871956.
- Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (Dec 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
External links
- PBX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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