Sudden infant death syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S[2]


Sudden infant death syndrome (SIDS) may be caused by genetic mutations, brainstem abnormality, airflow obstruction, and infections.


Common Causes

Common causes of Sudden infant death syndrome (SIDS) may include:[1][2][3]

Less Common Causes

Less common causes of Sudden infant death syndrome (SIDS) include:

Causes by Organ System

Cardiovascular Cardiac ion channel defects
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental Prone position
Gastroenterologic No underlying causes
Genetic Genetic mutations in SCN5A, SCN4A, KCNQ1, KCNH2, RYR2
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Infections
Musculoskeletal/Orthopedic No underlying causes
Neurologic Brain stem anomalies
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes
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  1. Van Norstrand DW, Valdivia CR, Tester DJ, Ueda K, London B, Makielski JC; et al. (2007). "Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome". Circulation. 116 (20): 2253–9. doi:10.1161/CIRCULATIONAHA.107.704627. PMC 3332545. PMID 17967976.
  2. Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A; et al. (2010). "Sudden infant death syndrome-associated mutations in the sodium channel beta subunits". Heart Rhythm. 7 (6): 771–8. doi:10.1016/j.hrthm.2010.01.032. PMC 2909680. PMID 20226894.
  3. Schwartz PJ, Stramba-Badiale M, Segantini A, Austoni P, Bosi G, Giorgetti R; et al. (1998). "Prolongation of the QT interval and the sudden infant death syndrome". N Engl J Med. 338 (24): 1709–14. doi:10.1056/NEJM199806113382401. PMID 9624190.