Small intestine cancer epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Parminder Dhingra, M.D. [3]


Males are more commonly affected with small intestine cancer than females. Male to female ratio is approximately 1.4 to 1. Small intestine cancer usually affects individuals of the African-Americans race. Caucasian individuals are less likely to develop small intestine cancer.

Epidemiology and Demographics


  • Incidence of small intestine cancer has increased recently, particularly in African-American males and it is unchanged for the females.[1]
  • Age-adjusted number of new cases of small intestine cancer in 2011-2015 was 2.3 per 100,000 individuals per year.[2]
  • According to a study done among in 2014, the age standardized incidence rates for small intestinal cancers were 5.5 and 4.8 per 100,000 person-years for men and women, respectively. For the histologic subtypes, the incidence rates per 100,000 person-years were 2.2 and 1.3 for adenocarcinomas, and 2.6 and 2.9 for carcinoids, for men and women, respectively.[3]
Incidence of small intestine cancer according to gender
Types of Intestinal cancers Gender (incidence per 100,000 person years)
Women Men
Age standardized Incidence of all types 4.8 5.5
Adenocarcinoma 1.3 2.2
Carcinoid tumor 2.9 2.6


Mortality rate

  • According to SEERS, the average annual age-adjusted mortality rate for small intestinal cancer in African-American is more than in White population (0.7 vs. 0.5 per 100,000 in males, respectively; 0.5 vs. 0.3 in females, respectively).[2]
  • Small intestine cancer contributed to 0.2% of all cancer deaths in 2018.
Age-adjusted mortality rate from small intestine cancer according to race
Race Gender (incidence per 100,000 person years)
Women Men
African-American 0.7 0.5
White 0.5 0.3


  • Age adjusted incidence rates were 1.2 per 100,000 individuals for men and 0.8 per 100,000 individuals for women, as shown by a study done in 2006.[5]



  1. Severson RK, Schenk M, Gurney JG, Weiss LK, Demers RY (February 1996). "Increasing incidence of adenocarcinomas and carcinoid tumors of the small intestine in adults". Cancer Epidemiol. Biomarkers Prev. 5 (2): 81–4. PMID 8850266.
  2. 2.0 2.1 "Small Intestine Cancer - Cancer Stat Facts".
  3. Miller RR, Menke JA, Hansen NB, Zwick DL, Bickers RG, Nowicki PT (August 1986). "The effect of naloxone on the hemodynamics of the newborn piglet with septic shock". Pediatr. Res. 20 (8): 707–10. doi:10.1203/00006450-198608000-00001. PMID 3737280.
  4. North JH, Pack MS (January 2000). "Malignant tumors of the small intestine: a review of 144 cases". Am Surg. 66 (1): 46–51. PMID 10651347.
  5. Lepage C, Bouvier AM, Manfredi S, Dancourt V, Faivre J (December 2006). "Incidence and management of primary malignant small bowel cancers: a well-defined French population study". Am. J. Gastroenterol. 101 (12): 2826–32. doi:10.1111/j.1572-0241.2006.00854.x. PMID 17026561.
  6. Pan SY, Morrison H (March 2011). "Epidemiology of cancer of the small intestine". World J Gastrointest Oncol. 3 (3): 33–42. doi:10.4251/wjgo.v3.i3.33. PMC 3069308. PMID 21461167.

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