Small intestine cancer causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2]


There are no established causes for small intestine cancer. Cancer may arise in genetically predisposed individuals or they may arise sporadically. Environmental factors may play a role as well; however, there is no study demonstrating established risk factors.


  • There is no established cause for small intestinal cancer.
  • However, some genetic syndromes are associated with small intestine cancers.
  • Intestinal cancer caused by the genetic syndrome in the presence of a family history, are diagnosed at a younger age.
  • Single nucleotide mutations, either on the same chromosome or on different chromosomes are considered to be associated with such cancer-associated genetic syndromes.
  • Small intestinal cancers may also be sporadic.[1]
  • According to some studies done in Europe and United States, tobacco, alcohol, and obesity are considered to play a role in the etiology of small intestine cancers.[2]


  1. Jass JR (December 2007). "Gastrointestinal polyposes: clinical, pathological and molecular features". Gastroenterol. Clin. North Am. 36 (4): 927–46, viii. doi:10.1016/j.gtc.2007.08.009. PMID 17996798.
  2. Boffetta P, Hazelton WD, Chen Y, Sinha R, Inoue M, Gao YT, Koh WP, Shu XO, Grant EJ, Tsuji I, Nishino Y, You SL, Yoo KY, Yuan JM, Kim J, Tsugane S, Yang G, Wang R, Xiang YB, Ozasa K, Nagai M, Kakizaki M, Chen CJ, Park SK, Shin A, Ahsan H, Qu CX, Lee JE, Thornquist M, Rolland B, Feng Z, Zheng W, Potter JD (July 2012). "Body mass, tobacco smoking, alcohol drinking and risk of cancer of the small intestine--a pooled analysis of over 500,000 subjects in the Asia Cohort Consortium". Ann. Oncol. 23 (7): 1894–8. doi:10.1093/annonc/mdr562. PMC 3493138. PMID 22147734.