Peripartum mood disturbances pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunita Kumawat, M.B.B.S[2]


Peripartum mood disturbances are mainly the mood alterations or changes seen in the women during and after the delivery. It involes the complex pathophysiology which is regulated by expression of different genes and neuroendocrine hormones. The genes playing important role are mainly Estrogen receptor alpha gene Polymorphisms in the serotonin transporter gene, 5-HTTgene encoding for MAOA and the gene encoding for Catechol-O-methyltransferase (COMT), Genetic variants for the TPH2 gene, SNP in OXT; SNP in the OXTR gene and methylation state was detected in association with postpartum depression. Hemicentin 1 gene (HMNC1) along with the neuroendocrine hormones maily GABA, Glutamate, serotonin and , or dopamine.


Pathophysiology of postpartum depression.

Pathophysiology of Peripartum mood disturbances- Pathophysiology of Peripartum mood disturbances includes the role of various genes and hormones as described below:

GABA Glutamate Serotonin Dopamine
GABA which is an inhibitory neurotransmitter in the brain Glutamate is the excitatory neurotransmitter in the brain Serotonin to 5HT1A receptors is decreased in the following brain regions Mutations in DR1
Level is inversely related with the depression symptoms in the postpartum period postpartum depression its level are increased in the medial prefrontal cortex mesiotemporal and anterior cingulate cortices. Relates to the attention and affection of mother for the baby
In postpartum depression decreased in the dorsolateral prefrontal cortex.


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