Peripartum mood disturbances medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sunita Kumawat, M.B.B.S[2]


To manage peripartum mood disturbances efficiently, a multidisciplinary and comprehensive approach is used.

Medical Therapy

Reassurance, familial and social support, psychoeducation, and, in certain circumstances, psychotherapy and/or pharmacologic treatment are all used in the treatment of PPDs. Medical therapy for postpartum depression includes:
All Postpartum Depression [1]

Postpartum depression: moderate severity or not in remission from self-care and psychosocial strategies

Postpartum Depression: Severe

Additional therapeutic options: bright light therapy, yoga, relaxation training, massage and acupunture.
Alternative treatment options are omega-3 PUFAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have fewer side effects.

Postpartum psychosis is a medical emergency and requires prompt inpatient treatment. Once the organic causes of psychosis are ruled out the treatment is given according to the symptom profile.
Antipsychotics, mood stabilizers and benzodiazepines are used in acute therapy. Insomnia should be treated promptly. ECT is used when the condition is treatment resistant or a quicker response is required because of symptoms severity or safety concerns. Antimaniac and antipsychotic agents benefit a patient who has a known history of the illness or a family member has a history.[2]
Before being discharged from the hospital, a strategy must be in place that includes close monitoring, appropriate sleep, and stress reduction.[3]

  • The majority of cases of Postpartum blues are self-limited and temporary. The mainstay of therapy is supportive care. As a result, it resolves on its own, requiring reassurance, education, validation, and psychological support.[4]


  1. "Postpartum Depression: Pathophysiology, Treatment, and Emerging Therapeutics | Annual Review of Medicine".
  2. "Pharmacotherapy of postpartum psychosis: Expert Opinion on Pharmacotherapy: Vol 4, No 10".
  3. "A Review of Postpartum Psychosis | Journal of Women's Health".
  4. Seyfried LS, Marcus SM (August 2003). "Postpartum mood disorders". Int Rev Psychiatry. 15 (3): 231–42. doi:10.1080/0954026031000136857. PMID 15276962.

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