Kaposi's sarcoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [3]

Overview

The optimal therapy for Kaposi's sarcoma depends on multiple factors. Management strategies varies depending on the specific variant of Kaposi's sarcoma. Classic Kaposi's sarcoma management may range from no treatment to either radiotherapy, local therapeutic interventions, or surgical excision. Iatrogenic Kaposi's sarcoma management focuses on modifying immunosuppressive therapy in addition to local therapeutic interventions. Endemic Kaposi's sarcoma is primarily managed by systemic chemotherapy. However, there is no curative treatment for epidemic Kaposi's sarcoma; the mainstay management for such patients is HAART therapy which aims for the control of Kaposi's sarcoma progression.

Medical Therapy

  • The optimal therapy for Kaposi's sarcoma depends on multiple factors which include:[1][2]
  • Management strategies varies depending on the specific variant of Kaposi's sarcoma such as:
  • Local/regional therapy recommended for the management of Kaposi's sarcoma patients may include:[3]
  • HAART therapy regimens recommended for the management of Kaposi's sarcoma patients may include:[4][5]
  • Chemotherapy regimens recommended for the management of Kaposi's sarcoma patients may include:[6]
  • Immune modulators recommended for the management of Kaposi's sarcoma patients may include:[7]
  • Targeted therapies recommended for the management of Kaposi's sarcoma patients may include:[8]

References

  1. Fatahzadeh M (2012). "Kaposi sarcoma: review and medical management update". Oral Surg Oral Med Oral Pathol Oral Radiol. 113 (1): 2–16. doi:10.1016/j.tripleo.2011.05.011. PMID 22677687.
  2. Masur H, Brooks JT, Benson CA, Holmes KK, Pau AK, Kaplan JE; et al. (2014). "Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America". Clin Infect Dis. 58 (9): 1308–11. doi:10.1093/cid/ciu094. PMC 3982842. PMID 24585567.
  3. Dittmer DP, Krown SE (September 2007). "Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus". Curr Opin Oncol. 19 (5): 452–7. doi:10.1097/CCO.0b013e3281eb8ea7. PMC 2855645. PMID 17762570.
  4. Krown SE (February 2004). "Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi's sarcoma". J. Clin. Oncol. 22 (3): 399–402. doi:10.1200/JCO.2004.08.064. PMID 14752065.
  5. Nguyen HQ, Magaret AS, Kitahata MM, Van Rompaey SE, Wald A, Casper C (May 2008). "Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response". AIDS. 22 (8): 937–45. doi:10.1097/QAD.0b013e3282ff6275. PMC 2730951. PMID 18453853.
  6. Gelmann EP, Longo D, Lane HC, Fauci AS, Masur H, Wesley M, Preble OT, Jacob J, Steis R (March 1987). "Combination chemotherapy of disseminated Kaposi's sarcoma in patients with the acquired immune deficiency syndrome". Am. J. Med. 82 (3): 456–62. PMID 2435150.
  7. Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ (July 2006). "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview". J. Gen. Virol. 87 (Pt 7): 1781–804. doi:10.1099/vir.0.81919-0. PMID 16760382.
  8. Sullivan RJ, Pantanowitz L, Dezube BJ (2009). "Targeted therapy for Kaposi sarcoma". BioDrugs. 23 (2): 69–75. PMC 2707492. PMID 19489649.

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