HLA-A25
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major histocompatibility complex (human), class I, A25
| ||
| Alleles | A*2501 A*2502 | |
| Structure (See HLA-A) | ||
| Identifiers | 2501 2502
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*2501 | |
| EBI-HLA | A*2502 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A25 (A25) is an HLA-A serotype. The serotype identifies the more common HLA-A*25 gene products. A25 is a split antigen of the A10 broad antigen serotype group. It is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A26 is more common in Western Europe.
Serotype
| A*25 | A25 | A10 | Sample |
| allele | % | % | size (N) |
| 2501 | 95 | 2 | 1375 |
| 2502 | 80 | 5 |
There are 7 alleles for A25, 6 that result in different isoforms.
A25 frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Saudi Arabia | 5.7 |
| [3] | India Jalpaiguri Toto | 5.2 |
| [3] | Russia Northwest | 5.0 |
| [3] | Spain Pas Valley | 4.3 |
| [3] | Czech Republic | 4.2 |
| [3] | Spain North Cantabrian | 4.2 |
| [3] | Russia Arkhangelsk Pomors | 4.0 |
| [3] | Croatia | 3.9 |
| [3] | Spain North Cabuernigo | 3.8 |
| [3] | Russia Chuvash | 3.7 |
| [3] | Romanian | 3.5 |
| [3] | Italy Bergamo | 3.2 |
| [3] | Croatia | 3.0 |
| [3] | Israel Ashkenazi Jews | 2.8 |
| [3] | Bulgaria | 2.7 |
| [3] | Spain Basque Arratia Valley | 2.7 |
| [3] | Sweden Uppsala County | 2.6 |
| [3] | Ireland Northern | 2.1 |
| [3] | Turkey | 2.1 |
| [3] | Wales | 2.1 |
| [3] | Spain Eastern Andalusia | 2.0 |
| [3] | Georgia Svaneti Svans | 1.9 |
| [3] | Italy | 1.9 |
| [3] | England Manchester | 1.9 |
| [3] | England Lancaster | 1.8 |
| [3] | Jews (Israel) | 1.7 |
| [3] | Macedonia | 1.7 |
| [3] | England Sheffield | 1.6 |
| [3] | Portugal South pop2 | 1.4 |
| [3] | Italy South Campania | 1.2 |
| [3] | Uganda Kampala | 1.2 |
| [3] | Finland | 1.1 |
| [3] | Portugal North | 1.1 |
| [3] | Belgium | 1.0 |
| [3] | France Corsica | 1.0 |
| [3] | Mongolia Oold | 1.0 |
| [3] | Russia Murmansk Saomi | 1.0 |
| [3] | Tunisia | 1.0 |
| [3] | France South East | 0.8 |
| [3] | Morocco Nador Metalsa | 0.7 |
| [3] | Greece | 0.6 |
| [3] | Italy North Pavia | 0.6 |
| [3] | Algeria | 0.5 |
| [3] | China Qinghai Hui | 0.5 |
| [3] | Guatemala Mayans | 0.4 |
| [3] | Russia Nenets | 0.4 |
| [3] | Cameroon Beti | 0.3 |
| [3] | Beijing Shijiazhuang | 0.1 |
| [3] | Taiwan Hakka | 0.1 |
A*2501 distribution is primarily located in western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.
References
- ↑ Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. PMID 8475492.
- ↑ derived from IMGT/HLA
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 3.48 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in
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