Benign vascular tumor

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For information about classification of vascular tumors, click here.

Vascular Tumor

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Overview

Classification

Benign Vascular tumor
Locally aggressive or borderline vascular tumors
Malignant vascular tumors

Benign Vascular Tumor Home Page

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]


Overview

Benign vascular tumors, are benign growths formed from blood vessels; such as, hemangioma, hemangioendothelioma, Kaposi sarcoma. They exhibit a wide range of clinical manifestations, and may occur as isolated lesions or may occur as manifestation of multi-system syndromes and diseases. Their diagnosis and management depends on their clinical manifestations and coexistent anomalies. International Society for the Study of Vascular Anomalies (ISSVA) has classified these lesions into benign vascular tumors and related lesions.

Benign Vascular Tumors

Infantile hemangioma / Hemangioma of infancy

Pattern Different types
  • Focal
  • Multifocal
  • Segmental
  • Indeterminate
  • Superficial
  • Deep
  • Mixed (superficial + deep)
  • Reticular / abortive / minimal growth
  • Others
Adapted from International Society for the Study of Vascular Anomalies[1]
Association with other lesions
PHACE association /

syndrome

Posterior fossa malformations, Hemangioma, Arterial

anomalies, Cardiovascular anomalies, Eye anomalies ,

sternal clefting and ⁄ or supraumbilical raphe

LUMBAR (SACRAL,

PELVIS) association /

syndrome

Lower body hemangioma, Urogenital anomalies,

Ulceration, Myelopathy, Bony deformities, Anorectal

malformations, Arterial anomalies, and Renal anomalies

Adapted from International Society for the Study of Vascular Anomalies[1]

Congenital hemangioma

  • Rare tumor that arises in utero and presents as fully developed lesion at birth. Following birth they can regress completely, partially or not at all. So they can be classified as rapidly involuting (RICH), non-involuting (NICH), partially involuting (PICH).[17][18]
    1. Rapidly involuting (RICH)
    2. Non-involuting (NICH)
      • Fast flow tumor that presents as well defined, plaque like lesion with pink to purple color, telangiectasias and pale borders.
      • Typically remains stable but there have been some reports of growth and expansion.[18]
    3. Partially involuting (PICH)
      • These lesions start involution as RICH but become stable over time and persist as NICH.[20]
  • Somatic mutations in GNAQ/GNA11 are thought to cause the congenital hemangioma. GNAQ and its paralogue GNA11 function in intracellular signaling pathways as Gq alpha subunit.[18][21]
  • Diagnosis is usually clinical but imaging techniques such as MRI, CT scan, contrast-enhanced ultrasound and later biopsy can be considered if required. Surgical excision should be considered in case of complications, NICH and PICH.[22][23]

Tufted angioma

For more information on tufted angioma, click here

Spindle-cell hemangioma

  • Rare benign tumor that manifests as solitary or multiple nodules confined to dermis and subcutaneous tissues in almost all of the cases. Histopathologically, it appears as solid areas that are cellular and consist of spindle cells seen attached to vessel walls, and cavernous spaces that can be thrombosed. Size may increase over time and patient usually complains of swelling and pain. The nodules or masses can be mobile and elastic or can be firm and immobile.[36][37][38]
  • Somatic mutations in IDH1 and IDH2 have been found to be present in 70% of spindle-cell hemangiomas. IDH1 and IDH2 are important enzymes in cell energy cycles (α-ketoglutarate and NADPH generation).[39][40]
  • Diagnosis often requires biopsy and imaging studies such as MRI to ascertain the extent of the tumor. Local excision is the treatment modality of choice with excellent prognosis in majority of the cases although recurrence is very common.[36][37][38][41][42]

Epithelioid hemangioma

For more information on epithelioid hemangioma, click here

Pyogenic granuloma

For more information on Pyogenic granuloma, click here.

Hobnail hemangioma

Microvenular hemangioma

  • Rare lesion that most often manifests as single asymptomatic nodule, plaque or papule with color varying from red to bluish-red. Majority of the lesions are located on trunk and limbs. Histologically, the tumor consists of irregular and branching venous structures with inconspicuous lumina. Endothelial cells display absence of atypia and mitotic figures. Some lesions may be painful and/or tender.[68][69][70][71]
  • Etiology and pathogenesis have not been well-understood but a recent study may associate progesterone with microvenular hemangioma.[72]
  • Diagnosis requires biopsy because of rarity of this tumor. Treatment is through surgical excision.[68][69][70][71]

Anastomosing hemangioma

Glomeruloid hemangioma

Papillary hemangioma

Intravascular papillary endothelial hyperplasia

Cutaneous epithelioid angiomatous nodule

Acquired elastotic hemangioma

Littoral cell hemangioma of the spleen

Related lesions

Eccrine angiomatous hamartoma

Reactive angioendotheliomatosis

Bacillary angiomatosis

For more information on bacillary angiomatosis, click here.

References

  1. 1.0 1.1 "Classification | International Society for the Study of Vascular Anomalies".
  2. 2.0 2.1 2.2 2.3 Smith C, Friedlander SF, Guma M, Kavanaugh A, Chambers CD (July 2017). "Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment". Birth Defects Res. 109 (11): 809–815. doi:10.1002/bdr2.1023. PMC 5839165. PMID 28402073. Vancouver style error: initials (help)
  3. Chiller KG, Passaro D, Frieden IJ (December 2002). "Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex". Arch Dermatol. 138 (12): 1567–76. PMID 12472344.
  4. Greenberger S, Bischoff J (September 2011). "Infantile hemangioma-mechanism(s) of drug action on a vascular tumor". Cold Spring Harb Perspect Med. 1 (1): a006460. doi:10.1101/cshperspect.a006460. PMC 3234458. PMID 22229118.
  5. Rotter A, Samorano LP, Rivitti-Machado MC, Oliveira Z, Gontijo B (June 2018). "PHACE syndrome: clinical manifestations, diagnostic criteria, and management". An Bras Dermatol. 93 (3): 405–411. doi:10.1590/abd1806-4841.20187693. PMC 6001075. PMID 29924216. Vancouver style error: initials (help)
  6. Castrén E, Salminen P, Vikkula M, Pitkäranta A, Klockars T (November 2016). "Inheritance Patterns of Infantile Hemangioma". Pediatrics. 138 (5). doi:10.1542/peds.2016-1623. PMID 27940781.
  7. Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, Horii KA, Lucky AW, Mancini AJ, Metry DW, Newell B, Nopper AJ, Frieden IJ (March 2007). "Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics". J. Pediatr. 150 (3): 291–4. doi:10.1016/j.jpeds.2006.12.003. PMID 17307549.
  8. Drolet BA, Swanson EA, Frieden IJ (November 2008). "Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants". J. Pediatr. 153 (5): 712–5, 715.e1. doi:10.1016/j.jpeds.2008.05.043. PMID 18940356.
  9. Darrow DH, Greene AK, Mancini AJ, Nopper AJ (October 2015). "Diagnosis and Management of Infantile Hemangioma: Executive Summary". Pediatrics. 136 (4): 786–91. doi:10.1542/peds.2015-2482. PMID 26416928.
  10. Ceisler EJ, Santos L, Blei F (2004). "Periocular hemangiomas: what every physician should know". Pediatr Dermatol. 21 (1): 1–9. PMID 14871317.
  11. Tal R, Dotan M, Lorber A (June 2016). "Approach to haemangiomatosis causing congestive heart failure". Acta Paediatr. 105 (6): 600–4. doi:10.1111/apa.13359. PMID 26859502.
  12. Hogeling M, Adams S, Wargon O (August 2011). "A randomized controlled trial of propranolol for infantile hemangiomas". Pediatrics. 128 (2): e259–66. doi:10.1542/peds.2010-0029. PMID 21788220.
  13. Bennett ML, Fleischer AB, Chamlin SL, Frieden IJ (September 2001). "Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation". Arch Dermatol. 137 (9): 1208–13. PMID 11559219.
  14. Perez J, Pardo J, Gomez C (2002). "Vincristine--an effective treatment of corticoid-resistant life-threatening infantile hemangiomas". Acta Oncol. 41 (2): 197–9. PMID 12102167.
  15. Schiestl C, Neuhaus K, Zoller S, Subotic U, Forster-Kuebler I, Michels R, Balmer C, Weibel L (April 2011). "Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas". Eur. J. Pediatr. 170 (4): 493–501. doi:10.1007/s00431-010-1324-2. PMID 20936416.
  16. Chinnadurai S, Sathe NA, Surawicz T (March 2016). "Laser treatment of infantile hemangioma: A systematic review". Lasers Surg Med. 48 (3): 221–33. doi:10.1002/lsm.22455. PMID 26711436.
  17. 17.0 17.1 "www.issva.org" (PDF).
  18. 18.0 18.1 18.2 18.3 Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK, Warman ML (April 2016). "Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma". Am. J. Hum. Genet. 98 (4): 789–95. doi:10.1016/j.ajhg.2016.03.009. PMC 4833432. PMID 27058448.
  19. Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, Burrows PE, Perez-Atayde AR, Kozakewich HP (2003). "Rapidly involuting congenital hemangioma: clinical and histopathologic features". Pediatr. Dev. Pathol. 6 (6): 495–510. PMID 15018449.
  20. Nasseri E, Piram M, McCuaig CC, Kokta V, Dubois J, Powell J (January 2014). "Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature". J. Am. Acad. Dermatol. 70 (1): 75–9. doi:10.1016/j.jaad.2013.09.018. PMID 24176519.
  21. "Error 403".
  22. Ramphul K, Mejias SG, Ramphul-Sicharam Y, Sonaye R (April 2018). "Congenital Hemangioma: A Case Report of a Finding Every Physician Should Know". Cureus. 10 (4): e2485. doi:10.7759/cureus.2485. PMC 6003795. PMID 29922526.
  23. Thimm MA, Rhee D, Takemoto CM, Karnsakul W, Cuffari C, Guerrerio AL, Garcia A, Gearhart J, Huisman T, Hwang M (October 2018). "Diagnosis of congenital and acquired focal lesions in the neck, abdomen, and pelvis with contrast-enhanced ultrasound: a pictorial essay". Eur. J. Pediatr. 177 (10): 1459–1470. doi:10.1007/s00431-018-3197-8. PMID 29971555. Vancouver style error: initials (help)
  24. 24.0 24.1 Prasuna A, Rao PN (2015). "A tufted angioma". Indian Dermatol Online J. 6 (4): 266–8. doi:10.4103/2229-5178.160259. PMC 4513407. PMID 26225332.
  25. Jones EW, Orkin M (February 1989). "Tufted angioma (angioblastoma). A benign progressive angioma, not to be confused with Kaposi's sarcoma or low-grade angiosarcoma". J. Am. Acad. Dermatol. 20 (2 Pt 1): 214–25. PMID 2644316.
  26. Pesapane F, Nazzaro G, Alberti-Violetti S, Gianotti R (2015). "A case of acquired tufted angioma in adulthood". An Bras Dermatol. 90 (3 Suppl 1): 16–8. doi:10.1590/abd1806-4841.20153733. PMC 4540497. PMID 26312663.
  27. 27.0 27.1 27.2 Bandyopadhyay D, Saha A (2015). "Multifocal Annular Tufted Angioma: An Uncommon Clinical Entity". Indian J Dermatol. 60 (4): 422. doi:10.4103/0019-5154.160528. PMC 4533571. PMID 26288441.
  28. Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA (August 2016). "GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation". Am. J. Hum. Genet. 99 (2): 443–50. doi:10.1016/j.ajhg.2016.06.010. PMC 4974082. PMID 27476652.
  29. "GNA14 G protein subunit alpha 14 [Homo sapiens (human)] - Gene - NCBI".
  30. Ghosh SK, Bandyopadhyay D, Ghosh A, Biswas SK, Barma KD (July 2011). "Acquired multifocal tufted angiomas in an immunocompetent young adult". Indian J Dermatol. 56 (4): 412–4. doi:10.4103/0019-5154.84741. PMC 3179005. PMID 21965850.
  31. Osio A, Fraitag S, Hadj-Rabia S, Bodemer C, de Prost Y, Hamel-Teillac D (July 2010). "Clinical spectrum of tufted angiomas in childhood: a report of 13 cases and a review of the literature". Arch Dermatol. 146 (7): 758–63. doi:10.1001/archdermatol.2010.135. PMID 20644037.
  32. Chiu CS, Yang LC, Hong HS, Kuan YZ (2007). "Treatment of a tufted angioma with intense pulsed light". J Dermatolog Treat. 18 (2): 109–11. doi:10.1080/09546630601028752. PMID 17520468.
  33. Yesudian PD, Parslew R, Klafowski J, Gould D, Pizer B (February 2008). "Tufted angioma-associated Kasabach-Merritt syndrome treated with embolization and vincristine". Plast. Reconstr. Surg. 121 (2): 692–3. doi:10.1097/01.prs.0000298541.92722.5d. PMID 18301012.
  34. Silva C, Schettini A, Santos M, Chirano C (2017). "Tufted angioma". An Bras Dermatol. 92 (5): 742–743. doi:10.1590/abd1806-4841.20175896. PMC 5674719. PMID 29166525. Vancouver style error: initials (help)
  35. Kimura R, Yoshida Y, Wakumoto K, Yamada N, Yamamoto O (October 2017). "Successful treatment of tufted angioma with low-dose electron beam radiation therapy: Report of two cases". J. Dermatol. 44 (10): e262–e263. doi:10.1111/1346-8138.13936. PMID 28623854.
  36. 36.0 36.1 Murakami K, Yamamoto K, Sugiura T, Kirita T (2018). "Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature". Case Rep Dent. 2018: 1370701. doi:10.1155/2018/1370701. PMC 5892276. PMID 29780644.
  37. 37.0 37.1 Chavva S, Priya MH, Garlapati K, Reddy GS, Gannepalli A (June 2015). "Rare Case of Spindle Cell Haemangioma". J Clin Diagn Res. 9 (6): ZD19–21. doi:10.7860/JCDR/2015/11998.6080. PMC 4525619. PMID 26266229.
  38. 38.0 38.1 Minagawa T, Yamao T, Shioya R (2011). "Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma". Case Rep Surg. 2011: 481654. doi:10.1155/2011/481654. PMC 3350060. PMID 22606579.
  39. Pansuriya TC, van Eijk R, d'Adamo P, van Ruler MA, Kuijjer ML, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K, French PJ, Bovée JV (November 2011). "Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome". Nat. Genet. 43 (12): 1256–61. doi:10.1038/ng.1004. PMC 3427908. PMID 22057234.
  40. Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB (February 2012). "IDH mutation impairs histone demethylation and results in a block to cell differentiation". Nature. 483 (7390): 474–8. doi:10.1038/nature10860. PMC 3478770. PMID 22343901.
  41. Gray SS, Eltorky MA, Riascos RF, Montilla RD (June 2012). "Spindle cell hemangioma reoccurrence in the hand: case report". Hand (N Y). 7 (2): 194–9. doi:10.1007/s11552-012-9397-1. PMC 3351523. PMID 23730241.
  42. Perkins P, Weiss SW (October 1996). "Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior". Am. J. Surg. Pathol. 20 (10): 1196–204. PMID 8827025.
  43. 43.0 43.1 Barber E, Domes T (September 2014). "Painful erections secondary to rare epithelioid hemangioma of the penis". Can Urol Assoc J. 8 (9–10): E647–9. doi:10.5489/cuaj.1833. PMC 4164556. PMID 25295139.
  44. 44.0 44.1 Tsikopoulos K, Perdikakis E, Georgiannos D, Bisbinas I (March 2018). "Epithelioid hemangioma of the scapula treated with chemoembolization and microwave ablation: Α case report". Acta Orthop Traumatol Turc. 52 (2): 157–161. doi:10.1016/j.aott.2017.01.003. PMC 6136344. PMID 28159479.
  45. Gong QX, Fan QH, Xie J, Su ZL, Zhang MH, Zhang ZH (September 2013). "[Epithelioid hemangioma: a clinicopathologic analysis of 7 cases]". Zhonghua Bing Li Xue Za Zhi (in Chinese). 42 (9): 593–8. PMID 24314244.
  46. Milde-Langosch K (November 2005). "The Fos family of transcription factors and their role in tumourigenesis". Eur. J. Cancer. 41 (16): 2449–61. doi:10.1016/j.ejca.2005.08.008. PMID 16199154.
  47. Durchdewald M, Angel P, Hess J (November 2009). "The transcription factor Fos: a Janus-type regulator in health and disease". Histol. Histopathol. 24 (11): 1451–61. doi:10.14670/HH-24.1451. PMID 19760594.
  48. Marconcini L, Marchio S, Morbidelli L, Cartocci E, Albini A, Ziche M, Bussolino F, Oliviero S (August 1999). "c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9671–6. PMC 22268. PMID 10449752.
  49. Huang SC, Zhang L, Sung YS, Chen CL, Krausz T, Dickson BC, Kao YC, Agaram NP, Fletcher CD, Antonescu CR (October 2015). "Frequent FOS Gene Rearrangements in Epithelioid Hemangioma: A Molecular Study of 58 Cases With Morphologic Reappraisal". Am. J. Surg. Pathol. 39 (10): 1313–21. doi:10.1097/PAS.0000000000000469. PMC 4567921. PMID 26135557.
  50. Gérard V, Tomasella M, Kurth W, Brands G, Lognard M (April 2015). "[Epithelioid hemangioma, a rare bone tumor]". Rev Med Liege (in French). 70 (4): 169–71. PMID 26054166.
  51. Marla V, Shrestha A, Goel K, Shrestha S (2016). "The Histopathological Spectrum of Pyogenic Granuloma: A Case Series". Case Rep Dent. 2016: 1323798. doi:10.1155/2016/1323798. PMC 4921146. PMID 27382492.
  52. 52.0 52.1 52.2 Thada SR, Pai KM, Agarwal P (May 2014). "A huge oral pyogenic granuloma with extensive alveolar bone loss and 'sun-ray' appearance mimicking a malignant tumour". BMJ Case Rep. 2014. doi:10.1136/bcr-2013-202367. PMC 4039851. PMID 24859551.
  53. 53.0 53.1 53.2 Wollina U, Langner D, França K, Gianfaldoni S, Lotti T, Tchernev G (July 2017). "Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options". Open Access Maced J Med Sci. 5 (4): 423–426. doi:10.3889/oamjms.2017.111. PMC 5535648. PMID 28785323.
  54. 54.0 54.1 Kamal R, Dahiya P, Puri A (January 2012). "Oral pyogenic granuloma: Various concepts of etiopathogenesis". J Oral Maxillofac Pathol. 16 (1): 79–82. doi:10.4103/0973-029X.92978. PMC 3303528. PMID 22434943.
  55. Simmons BJ, Chen L, Hu S (November 2016). "Pyogenic granuloma association with isotretinoin treatment for acne". Australas. J. Dermatol. 57 (4): e144–e145. doi:10.1111/ajd.12418. PMID 27885661.
  56. Inoue A, Sawada Y, Nishio D, Nakamura M (February 2017). "Pyogenic granuloma caused by afatinib: Case report and review of the literature". Australas. J. Dermatol. 58 (1): 61–62. doi:10.1111/ajd.12423. PMID 26603180.
  57. Henning B, Stieger P, Kamarachev J, Dummer R, Goldinger SM (June 2016). "Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation". Melanoma Res. 26 (3): 304–7. doi:10.1097/CMR.0000000000000248. PMID 27116335.
  58. Groesser L, Peterhof E, Evert M, Landthaler M, Berneburg M, Hafner C (February 2016). "BRAF and RAS Mutations in Sporadic and Secondary Pyogenic Granuloma". J. Invest. Dermatol. 136 (2): 481–6. doi:10.1038/JID.2015.376. PMID 26802240.
  59. Giblin AV, Clover AJ, Athanassopoulos A, Budny PG (2007). "Pyogenic granuloma - the quest for optimum treatment: audit of treatment of 408 cases". J Plast Reconstr Aesthet Surg. 60 (9): 1030–5. doi:10.1016/j.bjps.2006.10.018. PMID 17478135.
  60. Al-Mohaya MA, Al-Malik AM (December 2016). "Excision of oral pyogenic granuloma in a diabetic patient with 940nm diode laser". Saudi Med J. 37 (12): 1395–1400. doi:10.15537/smj.2016.12.15941. PMC 5303780. PMID 27874157.
  61. Malik M, Murphy R (December 2014). "A pyogenic granuloma treated with topical timolol". Br. J. Dermatol. 171 (6): 1537–8. doi:10.1111/bjd.13116. PMID 24836966.
  62. Millsop JW, Trinh N, Winterfield L, Berrios R, Hutchens KA, Tung R (March 2014). "Resolution of recalcitrant pyogenic granuloma with laser, corticosteroid, and timolol therapy". Dermatol. Online J. 20 (3). PMID 24656264.
  63. 63.0 63.1 63.2 Hiremath SK, Charantimath S, Byakodi S, Bijjal S, Byakodi R, Sapra G (July 2013). "Oral hobnail hemangioma: a case report". Arch Iran Med. 16 (7): 428–30. doi:013167/AIM.0013 Check |doi= value (help). PMID 23808782.
  64. 64.0 64.1 64.2 Yoon SY, Kwon HH, Jeon HC, Lee JH, Cho S (November 2011). "Congenital and multiple hobnail hemangiomas". Ann Dermatol. 23 (4): 539–43. doi:10.5021/ad.2011.23.4.539. PMC 3229956. PMID 22148030.
  65. Takayama R, Ueno T, Futagami A, Ansai S, Fukumoto T, Saeki H (2015). "Hobnail Hemangioma: A Case Report". J Nippon Med Sch. 82 (3): 151–5. doi:10.1272/jnms.82.151. PMID 26156669.
  66. Morganroth GS, Tigelaar RE, Longley BJ, Luck LE, Leffell DJ (February 1995). "Targetoid hemangioma associated with pregnancy and the menstrual cycle". J. Am. Acad. Dermatol. 32 (2 Pt 1): 282–4. PMID 7829718.
  67. Christenson LJ, Stone MS (June 2001). "Trauma-induced simulator of targetoid hemosiderotic hemangioma". Am J Dermatopathol. 23 (3): 221–3. PMID 11391103.
  68. 68.0 68.1 Mansur AT, Demirci GT, Ozbal Koc EA, Yildiz S (January 2018). "An unusual lesion on the nose: microvenular hemangioma". Dermatol Pract Concept. 8 (1): 7–11. doi:10.5826/dpc.0801a02. PMC 5808364. PMID 29445567.
  69. 69.0 69.1 Requena L, Sangueza OP (December 1997). "Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms". J. Am. Acad. Dermatol. 37 (6): 887–919, quiz 920–2. PMID 9418757.
  70. 70.0 70.1 Koch PS, Goerdt S, Peitsch WK (March 2015). "Solitary red-purple plaque on the chest of a 7-year-old boy: a quiz. Microvenular haemangioma". Acta Derm. Venereol. 95 (3): 378–82. doi:10.2340/00015555-1953. PMID 25138781.
  71. 71.0 71.1 Kim YC, Park HJ, Cinn YW (2003). "Microvenular hemangioma". Dermatology (Basel). 206 (2): 161–4. doi:10.1159/000068453. PMID 12592086.
  72. Juan YC, Chen CJ, Hsiao CH, Chiu TM (July 2018). "A microvenular hemangioma with a rare expression of progesterone receptor immunocreativity and a review of the literature". J. Cutan. Pathol. doi:10.1111/cup.13322. PMID 30019384.
  73. 73.0 73.1 Jin LU, Liu J, Li Y, Sun S, Mao X, Yang S, Lai Y (February 2016). "Anastomosing hemangioma: The first case report in the bladder". Mol Clin Oncol. 4 (2): 310–312. doi:10.3892/mco.2015.699. PMC 4734195. PMID 26893881.
  74. Ross M, Polcari A, Picken M, Sankary H, Milner J (September 2012). "Anastomosing hemangioma arising from the adrenal gland". Urology. 80 (3): e27–8. doi:10.1016/j.urology.2012.05.032. PMID 22840861.
  75. 75.0 75.1 Lin J, Bigge J, Ulbright TM, Montgomery E (November 2013). "Anastomosing hemangioma of the liver and gastrointestinal tract: an unusual variant histologically mimicking angiosarcoma". Am. J. Surg. Pathol. 37 (11): 1761–5. doi:10.1097/PAS.0b013e3182967e6c. PMID 23887160.
  76. 76.0 76.1 Cheon PM, Rebello R, Naqvi A, Popovic S, Bonert M, Kapoor A (June 2018). "Anastomosing hemangioma of the kidney: radiologic and pathologic distinctions of a kidney cancer mimic". Curr Oncol. 25 (3): e220–e223. doi:10.3747/co.25.3927. PMC 6023565. PMID 29962849.
  77. Perdiki M, Datseri G, Liapis G, Chondros N, Anastasiou I, Tzardi M, Delladetsima JK, Drakos E (January 2017). "Anastomosing hemangioma: report of two renal cases and analysis of the literature". Diagn Pathol. 12 (1): 14. doi:10.1186/s13000-017-0597-4. PMC 5260082. PMID 28118845.
  78. Bean GR, Joseph NM, Gill RM, Folpe AL, Horvai AE, Umetsu SE (May 2017). "Recurrent GNAQ mutations in anastomosing hemangiomas". Mod. Pathol. 30 (5): 722–727. doi:10.1038/modpathol.2016.234. PMID 28084343.
  79. Abboudi H, Tschobotko B, Carr C, DasGupta R (2017). "Bilateral Renal Anastomosing Hemangiomas: A Tale of Two Kidneys". J Endourol Case Rep. 3 (1): 176–178. doi:10.1089/cren.2017.0018. PMC 5734139. PMID 29279869.
  80. Peng X, Li J, Liang Z (September 2017). "Anastomosing haemangioma of liver: A case report". Mol Clin Oncol. 7 (3): 507–509. doi:10.3892/mco.2017.1341. PMC 5543263. PMID 28808574.
  81. 81.0 81.1 81.2 81.3 Gupta J, Kandhari R, Ramesh V, Singh A (March 2013). "Glomeruloid hemangioma in normal individuals". Indian J Dermatol. 58 (2): 160. doi:10.4103/0019-5154.108088. PMC 3657245. PMID 23716835.
  82. 82.0 82.1 82.2 82.3 Gupta V, Rai A, Mridha AR, Sharma VK (2016). "Multiple glomeruloid hemangiomas without POEMS syndrome". Indian J Dermatol Venereol Leprol. 82 (4): 442–4. doi:10.4103/0378-6323.181461. PMID 27279314.
  83. Nozza A (2017). "POEMS SYNDROME: an Update". Mediterr J Hematol Infect Dis. 9 (1): e2017051. doi:10.4084/MJHID.2017.051. PMC 5584767. PMID 28894560.
  84. Kahn F, Fagerström A, Segelmark M, Bakoush O (June 2008). "Irreversible Kidney Damage due to Multicentric Castleman's Disease". Libyan J Med. 3 (2): 101–3. doi:10.4176/080108. PMC 3074288. PMID 21499466.
  85. Suurmeijer AJ (February 2010). "Papillary hemangiomas and glomeruloid hemangiomas are distinct clinicopathological entities". Int. J. Surg. Pathol. 18 (1): 48–54. doi:10.1177/1066896908323504. PMID 18805868.
  86. Suurmeijer AJ, Fletcher CD (November 2007). "Papillary haemangioma. A distinctive cutaneous haemangioma of the head and neck area containing eosinophilic hyaline globules". Histopathology. 51 (5): 638–48. doi:10.1111/j.1365-2559.2007.02847.x. PMID 17927585.
  87. Schmidt-Erfurth UM, Kusserow C, Barbazetto IA, Laqua H (July 2002). "Benefits and complications of photodynamic therapy of papillary capillary hemangiomas". Ophthalmology. 109 (7): 1256–66. PMID 12093647.
  88. Akdur NC, Donmez M, Gozel S, Ustun H, Hucumenoglu S (October 2013). "Intravascular papillary endothelial hyperplasia: histomorphological and immunohistochemical features". Diagn Pathol. 8: 167. doi:10.1186/1746-1596-8-167. PMC 4016006. PMID 24125024.
  89. 89.0 89.1 Kim S, Jun JH, Kim J, Kim DW, Jang YH, Lee WJ, Chung HY, Lee SJ (2013). "HIF-1α and VEGF expression correlates with thrombus remodeling in cases of intravascular papillary endothelial hyperplasia". Int J Clin Exp Pathol. 6 (12): 2912–8. PMC 3843272. PMID 24294378.
  90. 90.0 90.1 Guledgud MV, Patil K, Saikrishna D, Madhavan A, Yelamali T (2014). "Intravascular papillary endothelial hyperplasia: diagnostic sequence and literature review of an orofacial lesion". Case Rep Dent. 2014: 934593. doi:10.1155/2014/934593. PMC 4033548. PMID 24891960.
  91. Hong SG, Cho HM, Chin HM, Park IY, Yoo JY, Hwang SS, Kim JG, Park WB, Chun CS (April 2004). "Intravascular papillary endothelial hyperplasia (Masson's hemangioma) of the liver: a new hepatic lesion". J. Korean Med. Sci. 19 (2): 305–8. doi:10.3346/jkms.2004.19.2.305. PMC 2822318. PMID 15082910.
  92. 92.0 92.1 Mahapatra QS, Sahai K, Malik A, Mani NS (2015). "Intravascular papillary endothelial hyperplasia: An unusual histopathological entity". Indian Dermatol Online J. 6 (4): 277–9. doi:10.4103/2229-5178.160269. PMC 4513410. PMID 26225335.
  93. Meadows MC, Sun X, Dardik M, Tarantino DR, Chamberlain RS (March 2010). "Intraabdominal Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor): A Rare and Novel Cause of Gastrointestinal Bleeding". Case Rep Gastroenterol. 4 (1): 124–132. doi:10.1159/000294148. PMC 2988909. PMID 21103239.
  94. 94.0 94.1 94.2 Blackwood L, Chapman I, Lyon M, Hernandez C (November 2016). "Multifocal eruptive cutaneous epithelioid angiomatous nodules". JAAD Case Rep. 2 (6): 454–456. doi:10.1016/j.jdcr.2016.09.013. PMC 5148776. PMID 27981217.
  95. 95.0 95.1 Chetty R, Kamil ZS, Wang A, Al Habeeb A, Ghazarian D (August 2018). "Cutaneous epithelioid angiomatous nodule: a report of a series including a case with moderate cytologic atypia and immunosuppression". Diagn Pathol. 13 (1): 50. doi:10.1186/s13000-018-0729-5. PMC 6090800. PMID 30103782.
  96. 96.0 96.1 Dastgheib L, Aslani FS, Sepaskhah M, Saki N, Motevalli D (March 2013). "A young woman with multiple cutaneous epithelioid angiomatous nodules (CEAN) on her forearm: a case report and follow-up of therapeutic intervention". Dermatol. Online J. 19 (3): 1. PMID 23551998.
  97. 97.0 97.1 97.2 Hicks T, Katz I (October 2016). "First description of the dermatoscopic features of acquired elastotic hemangioma-a case report". Dermatol Pract Concept. 6 (4): 35–37. doi:10.5826/dpc.0604a08. PMC 5108644. PMID 27867745.
  98. 98.0 98.1 98.2 Cohen PR, Hinds BR (December 2017). "Acquired Elastotic Hemangioma: Case Series and Comprehensive Literature Review". Cureus. 9 (12): e1994. doi:10.7759/cureus.1994. PMC 5832390. PMID 29507844.
  99. Requena L, Kutzner H, Mentzel T (September 2002). "Acquired elastotic hemangioma: A clinicopathologic variant of hemangioma". J. Am. Acad. Dermatol. 47 (3): 371–6. PMID 12196746.
  100. 100.0 100.1 100.2 Tong PL, Beer TW (December 2010). "Acquired elastotic hemangioma: ten cases with immunohistochemistry refuting a lymphatic origin in most lesions". J. Cutan. Pathol. 37 (12): 1259–60. doi:10.1111/j.1600-0560.2010.01610.x. PMID 20950363.
  101. Mendieta-Eckert M, Díaz-Ramón JL, Gardeazabal-García J (January 2018). "Response of an Acquired Elastotic Hemangioma to Vascular Laser". Dermatol Surg. 44 (1): 136–137. doi:10.1097/DSS.0000000000001105. PMID 28296791.
  102. 102.0 102.1 Hu ZQ, A YJ, Sun QM, Li W, Li L (December 2011). "The splenic Littoral cell angioma in China: a case report and review". World J Surg Oncol. 9: 168. doi:10.1186/1477-7819-9-168. PMC 3271992. PMID 22172167.
  103. 103.0 103.1 de Ridder GG, Galeotti J, Carney J, Wang E (November 2015). "Persistent thrombocytopaenia in a young man with splenomegaly, rebound thrombocytosis after splenectomy and subsequent pulmonary embolism: splenic littoral cell angioma and associated events". BMJ Case Rep. 2015. doi:10.1136/bcr-2015-212882. PMC 4680245. PMID 26604237.
  104. 104.0 104.1 104.2 Tee M, Vos P, Zetler P, Wiseman SM (August 2008). "Incidental littoral cell angioma of the spleen". World J Surg Oncol. 6: 87. doi:10.1186/1477-7819-6-87. PMC 2527567. PMID 18713469.
  105. 105.0 105.1 Cosme A, Tejada A, Bujanda L, Vaquero M, Elorza JL, Ojeda E, Goikoetxea U (December 2007). "Littoral-cell angioma of the spleen: a case report". World J. Gastroenterol. 13 (48): 6603–4. PMC 4611304. PMID 18161935.
  106. Harmon RL, Cerruto CA, Scheckner A (2006). "Littoral cell angioma: a case report and review". Curr Surg. 63 (5): 345–50. doi:10.1016/j.cursur.2006.06.011. PMID 16971207.
  107. Melzer N, Barth PJ, Müller KM, Foss HD, Krug U, Schilling M, Marziniak M, Grauer OM, Wiendl H (June 2012). "Rapidly progressive B-cell dominated inflammatory neuropathy and littoral cell angioma of the spleen associated with plasmablastic B-cell lymphoma". Leuk. Lymphoma. 53 (6): 1242–4. doi:10.3109/10428194.2011.640677. PMID 22098375.
  108. Chatelain D, Bonte H, Guillevin L, Balladur P, Flejou JF (November 2002). "Small solitary littoral cell angioma associated with splenic marginal zone lymphoma and villous lymphocyte leukaemia in a patient with hepatitis C infection". Histopathology. 41 (5): 473–5. PMID 12405918.
  109. Bisceglia M, Sickel JZ, Giangaspero F, Gomes V, Amini M, Michal M (1998). "Littoral cell angioma of the spleen: an additional report of four cases with emphasis on the association with visceral organ cancers". Tumori. 84 (5): 595–9. PMID 9862523.
  110. Johansson J, Björnsson B, Ignatova S, Sandström P, Ekstedt M (2015). "Littoral cell angioma in a patient with Crohn's disease". Case Rep Gastrointest Med. 2015: 474969. doi:10.1155/2015/474969. PMC 4326338. PMID 25705528.
  111. Gupta MK, Levin M, Aguilera NS, Pastores GM (September 2001). "Littoral cell angioma of the spleen in a patient with Gaucher disease". Am. J. Hematol. 68 (1): 61–2. PMID 11559940.
  112. Rosso R, Paulli M, Gianelli U, Boveri E, Stella G, Magrini U (October 1995). "Littoral cell angiosarcoma of the spleen. Case report with immunohistochemical and ultrastructural analysis". Am. J. Surg. Pathol. 19 (10): 1203–8. PMID 7573679.
  113. Bhatt S, Huang J, Dogra V (May 2007). "Littoral cell angioma of the spleen". AJR Am J Roentgenol. 188 (5): 1365–6. doi:10.2214/AJR.06.1157. PMID 17449783.
  114. Vancauwenberghe T, Snoeckx A, Vanbeckevoort D, Dymarkowski S, Vanhoenacker FM (March 2015). "Imaging of the spleen: what the clinician needs to know". Singapore Med J. 56 (3): 133–44. PMC 4371192. PMID 25820845.
  115. Liu D, Chen Z, Wang T, Zhang B, Zhou H, Li Q (May 2017). "Littoral-cell angioma of the spleen: a case report". Cancer Biol Med. 14 (2): 194–195. doi:10.20892/j.issn.2095-3941.2016.0094. PMC 5444933. PMID 28607812.
  116. 116.0 116.1 Shin J, Jang YH, Kim SC, Kim YC (May 2013). "Eccrine angiomatous hamartoma: a review of ten cases". Ann Dermatol. 25 (2): 208–12. doi:10.5021/ad.2013.25.2.208. PMC 3662915. PMID 23717013.
  117. Chien AJ, Asgari M, Argenyi ZB (June 2006). "Eccrine angiomatous hamartoma with elements of an arterio-venous malformation: a newly recognized variant". J. Cutan. Pathol. 33 (6): 433–6. doi:10.1111/j.0303-6987.2006.00272.x. PMC 4113075. PMID 16776719.
  118. Nygaard U, Dalager S, Spaun E, Hedelund L (September 2015). "Large eccrine angiomatous hamartoma: a novel clinical presentation of disease". J Dermatol Case Rep. 9 (3): 58–61. doi:10.3315/jdcr.2015.1211. PMC 4619160.
  119. Lee Y, Jung YJ, Lee WS (October 2011). "Late-onset eccrine angiomatous hamartoma associated with a ganglion cyst on the sole of the foot". Ann Dermatol. 23 (Suppl 2): S218–21. doi:10.5021/ad.2011.23.S2.S218. PMC 3229070. PMID 22148055.
  120. Yun JH, Kang HK, Na SY, Roh JY, Lee JR (September 2011). "Eccrine angiomatous hamartoma mimicking a traumatic hemorrhage". Ann Dermatol. 23 Suppl 1: S84–7. doi:10.5021/ad.2011.23.S1.S84. PMC 3199432. PMID 22028582.
  121. Nygaard U, Dalager S, Spaun E, Hedelund L (September 2015). "Large eccrine angiomatous hamartoma: a novel clinical presentation of disease". J Dermatol Case Rep. 9 (3): 58–61. doi:10.3315/jdcr.2015.1211. PMC 4619160. PMID 26512300.
  122. Kar S, Krishnan A, Gangane N (May 2012). "Eccrine angiomatous hamartoma: a rare skin lesion with diverse histological features". Indian J Dermatol. 57 (3): 225–7. doi:10.4103/0019-5154.96206. PMC 3371531. PMID 22707779.
  123. Barco D, Baselga E, Alegre M, Curell R, Alomar A (March 2009). "Successful treatment of eccrine angiomatous hamartoma with botulinum toxin". Arch Dermatol. 145 (3): 241–3. doi:10.1001/archdermatol.2008.575. PMID 19289750.
  124. Sen S, Chatterjee G, Mitra PK, Gangopadhyay A (July 2012). "Eccrine angiomatous naevus revisited". Indian J Dermatol. 57 (4): 313–5. doi:10.4103/0019-5154.97682. PMC 3401855. PMID 22837574.
  125. Fathaddin AA, Alhumidi AA (January 2013). "Eccrine angiomatous hamartoma, with verrocous hemangioma-like features: A case report". Int J Health Sci (Qassim). 7 (1): 103–6. PMC 3612410. PMID 23559910.
  126. Tantanasrigul P, Kootiratrakarn T, Wessagowit V, Kattipathanapong P, Sudtikoonaseth P (2015). "Eccrine Angiomatous Hamartoma in an Adolescent". Case Rep Dermatol. 7 (3): 233–6. doi:10.1159/000439399. PMC 4608655. PMID 26500534.
  127. 127.0 127.1 127.2 Boyapati A, Khan S, Mar A, Sheridan A (November 2013). "Reactive angioendotheliomatosis associated with cyroglobulinemia in a marathon runner". Dermatol. Online J. 19 (11): 20404. PMID 24314779.
  128. Lazova R, Slater C, Scott G (February 1996). "Reactive angioendotheliomatosis. Case report and review of the literature". Am J Dermatopathol. 18 (1): 63–9. PMID 8721593.
  129. Kirke S, Angus B, Kesteven PJ, Calonje E, Simpson N (January 2007). "Localized reactive angioendotheliomatosis". Clin. Exp. Dermatol. 32 (1): 45–7. doi:10.1111/j.1365-2230.2006.02254.x. PMID 17004988.
  130. 130.0 130.1 Thai KE, Barrett W, Kossard S (May 2003). "Reactive angioendotheliomatosis in the setting of antiphospholipid syndrome". Australas. J. Dermatol. 44 (2): 151–5. PMID 12752193.
  131. McMenamin ME, Fletcher CD (June 2002). "Reactive angioendotheliomatosis: a study of 15 cases demonstrating a wide clinicopathologic spectrum". Am. J. Surg. Pathol. 26 (6): 685–97. PMID 12023572.