Jump to: navigation, search
Structural formula of furazolidone
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
ATC code
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass225.16
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Furazolidine


Most recent articles on Furazolidine

Most cited articles on Furazolidine

Review articles on Furazolidine

Articles on Furazolidine in N Eng J Med, Lancet, BMJ


Powerpoint slides on Furazolidine

Images of Furazolidine

Photos of Furazolidine

Podcasts & MP3s on Furazolidine

Videos on Furazolidine

Evidence Based Medicine

Cochrane Collaboration on Furazolidine

Bandolier on Furazolidine

TRIP on Furazolidine

Clinical Trials

Ongoing Trials on Furazolidine at Clinical Trials.gov

Trial results on Furazolidine

Clinical Trials on Furazolidine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Furazolidine

NICE Guidance on Furazolidine


FDA on Furazolidine

CDC on Furazolidine


Books on Furazolidine


Furazolidine in the news

Be alerted to news on Furazolidine

News trends on Furazolidine


Blogs on Furazolidine


Definitions of Furazolidine

Patient Resources / Community

Patient resources on Furazolidine

Discussion groups on Furazolidine

Patient Handouts on Furazolidine

Directions to Hospitals Treating Furazolidine

Risk calculators and risk factors for Furazolidine

Healthcare Provider Resources

Symptoms of Furazolidine

Causes & Risk Factors for Furazolidine

Diagnostic studies for Furazolidine

Treatment of Furazolidine

Continuing Medical Education (CME)

CME Programs on Furazolidine


Furazolidine en Espanol

Furazolidine en Francais


Furazolidine in the Marketplace

Patents on Furazolidine

Experimental / Informatics

List of terms related to Furazolidine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Furazolidone is a nitrofuran antibacterial. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M. Diafuron, medaron


Furazolidone has been used in human and veterinary medicine. It has a broad spectrum of activity being active against

Use in humans

In humans it has used to treat diarrhoea and enteritis caused by bacteria or protozoan infections. It has been used to treat traveler's diarrhoea, cholera and bacteremic salmonellosis. Use in treating Helicobacter pylori infections has also been proposed.[1]

Furazolidone is also used for giardiasis (due to Giardia lamblia), though it is not a first line treatment.[2]

As for all medicines the most recent local recommendations for its use should be always be followed. The usual dose is:

  • Adult: 100 mg 4 times daily. Usual duration: 2-5 days, up to 7 days in some patients or 10 days for giardiasis.
  • Child: 1.25 mg/kg 4 times daily, usually given for 2-5 days or up to 10 days for giardiasis.

Use in animals

As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.

It has also been used in aquaculture.[3]

Since furazolidone is a nitrofuran antibiotic, its use in food animals is currently prohibited by the FDA under the Animal Medicinal Drug Use Clarification Act, 1994.[4]

Use in laboratory

It is used to differentiate micrococci and staphylococci.


It is believed to work by crosslinking of DNA.[5]

Side effects

Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, peripheral neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991.[6]

See also


  1. Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria. 84 (2): 160–5. doi:10.2223/JPED.1772. PMID 18372934.
  2. Petri WA (February 2005). "Treatment of Giardiasis" ([dead link]). Curr Treat Options Gastroenterol. 8 (1): 13–17. doi:10.1007/s11938-005-0047-3. PMID 15625030.
  3. Meng J, Mangat SS, Grudzinski IP, Law FC (1998). "Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout". Drug Metabol Drug Interact. 14 (4): 209–19. PMID 10694929.
  4. Bagley, Clell. "Drugs Prohibited from Extralabel Use in Animals". Retrieved 14 April 2014.
  5. "DrugBank: Showing Furazolidone (DB00614)". Retrieved 2008-12-19.
  6. http://caraga.da.gov.ph/services/banmed-Nitrofurans.htm[dead link]

Template:Excavata antiparasitics Template:Nucleic acid inhibitors