Beraprost

Beraprost

Gene therapy
Clinical data
Routes of administration	Oral
ATC code	B01AC19 (WHO)
Physiological data
Legal status
Legal status	?
Pharmacokinetic data
Bioavailability	50–70%
Metabolism	Unknown
Elimination half-life	35–40 minutes
Excretion	?
Identifiers
IUPAC name 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4- methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran- 5-butanoic acid
CAS Number	88430-50-6 88475-69-8 (sodium salt)
PubChem Template:Abbreviation	5282428
Chemical and physical data
Formula	C24H30O5
Molar mass	398.492 g/mol

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Evidence Based Medicine
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Clinical Trials
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Clinical Pharmacology

As an analogue of prostacyclin PGI₂, beraprost effects vasodilation, which in turn lowers the blood pressure. Beraprost also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined.

Dosage and administration

Beraprost is administered orally as a pill.