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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cytochrome P450 2C18''' is a [[protein]] that in humans is encoded by the ''CYP2C18'' [[gene]].<ref name="pmid1896026">{{cite journal | vauthors = Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ | title = Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA | journal = Molecular Pharmacology | volume = 40 | issue = 3 | pages = 375–82 | date = September 1991 | pmid = 1896026 | pmc =  | doi =  }}</ref><ref name="pmid2009263">{{cite journal | vauthors = Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA | title = Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily | journal = Biochemistry | volume = 30 | issue = 13 | pages = 3247–55 | date = April 1991 | pmid = 2009263 | pmc =  | doi = 10.1021/bi00227a012 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1562| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 2, subfamily C, polypeptide 18
| HGNCid = 2620
| Symbol = CYP2C18
| AltSymbols =; CYP2C; CPCI; CYP2C17; DKFZp686I24235; P450-6B/29C; P450IIC17
| OMIM = 601131
| ECnumber = 
| Homologene = 88339
| MGIid = 1919332
| GeneAtlas_image1 = PBB_GE_CYP2C18_208126_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP2C18_215103_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1562
    | Hs_Ensembl = ENSG00000108242
    | Hs_RefseqProtein = NP_000763
    | Hs_RefseqmRNA = NM_000772
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 96433368
    | Hs_GenLoc_end = 96485937
    | Hs_Uniprot = P33260
    | Mm_EntrezGene = 72082
    | Mm_Ensembl = ENSMUSG00000025002
    | Mm_RefseqmRNA = NM_028089
    | Mm_RefseqProtein = NP_082365
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 39072063
    | Mm_GenLoc_end = 39107731
    | Mm_Uniprot =
  }}
}}
{{SI}}
{{EH}}


'''Cytochrome P450, family 2, subfamily C, polypeptide 18''', also known as '''CYP2C18''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1562| accessdate = }}</ref>
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.<ref name="entrez" />


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CYP2C18 also possesses [[epoxygenase]] activitiy: it can attack various long-chain polyunsaturated fatty acids at their double (i.e. [[alkene]]) bonds to form [[epoxide]] products that act as signaling agents. It metabolizes: '''1)''' [[arachidonic acid]] to various [[epoxyeicosatrienoic acid]]s (also termed EETs); '''2)''' [[linoleic acid]] to 9,10-epoxy octadecaenoic acids (also termed [[vernolic acid]], linoleic acid 9:10-oxide, or leukotoxin) and 12,13-epoxy-octadecaenoic (also termed [[coronaric acid]], linoleic acid 12,13-oxide, or isoleukotoxin); '''3)''' docosohexaenoic acid to various [[epoxydocosapentaenoic acid]]s (also termed EDPs); and '''4)''' [[eicosapentaenoic acid]] to various epoxyeicosatetraenoic acids (also termed EEQs).<ref>{{cite journal | vauthors = Fleming I | title = The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease | journal = Pharmacological Reviews | volume = 66 | issue = 4 | pages = 1106–40 | date = October 2014 | pmid = 25244930 | doi = 10.1124/pr.113.007781 }}</ref><ref name="Wagner K 2014">{{cite journal | vauthors = Wagner K, Vito S, Inceoglu B, Hammock BD | title = The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling | journal = Prostaglandins & Other Lipid Mediators | volume = 113-115 | pages = 2–12 | date = October 2014 | pmid = 25240260 | doi = 10.1016/j.prostaglandins.2014.09.001 | pmc=4254344}}</ref><ref>{{cite journal | vauthors = Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH | title = Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway | journal = Journal of Lipid Research | volume = 55 | issue = 6 | pages = 1150–1164 | date = March 2014 | pmid = 24634501 | doi = 10.1194/jlr.M047357 | pmc=4031946}}</ref>
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP4218 and CYP2C19.<ref name="entrez">{{cite web | title = Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1562| accessdate = }}</ref>
}}


==References==
While CYP2C19, CYP2C8, [[CYP2C9]], [[CYP2J2]], and possibly [[CYP2S1]] are the main producers of EETs and, very likely EEQs, EDPs, and the epoxides of linoleic acid, CYP2C18 may contribute to the production of these metabolites in certain tissues.<ref name="Wagner K 2014"/><ref>{{cite journal | vauthors = Spector AA, Kim HY | title = Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism | journal = Biochimica et Biophysica Acta | volume = 1851 | issue = 4 | pages = 356–65 | date = April 2015 | pmid = 25093613 | doi = 10.1016/j.bbalip.2014.07.020 | pmc=4314516}}</ref>
{{reflist}}
 
==Further reading==
== References ==
{{refbegin | 2}}
{{reflist|33em}}
{{PBB_Further_reading
 
| citations =
==External links==
*{{cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285-99 |year= 1995 |pmid= 7704034 |doi= }}
* {{UCSC gene info|CYP2C18}}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
 
*{{cite journal | author=Ged C, Beaune P |title=Partial sequence and polymerase chain reaction-mediated analysis of expression of the human CYP2C18 gene. |journal=Pharmacogenetics |volume=2 |issue= 3 |pages= 109-15 |year= 1993 |pmid= 1306110 |doi= }}
== Further reading ==
*{{cite journal  | author=Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ |title=Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. |journal=Mol. Pharmacol. |volume=40 |issue= 3 |pages= 375-82 |year= 1991 |pmid= 1896026 |doi=  }}
{{refbegin|33em}}
*{{cite journal | author=Romkes M, Faletto MB, Blaisdell JA, ''et al.'' |title=Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. |journal=Biochemistry |volume=30 |issue= 13 |pages= 3247-55 |year= 1991 |pmid= 2009263 |doi=  }}
* {{cite journal | vauthors = Goldstein JA, de Morais SM | title = Biochemistry and molecular biology of the human CYP2C subfamily | journal = Pharmacogenetics | volume = 4 | issue = 6 | pages = 285–99 | date = December 1994 | pmid = 7704034 | doi = 10.1097/00008571-199412000-00001 }}
*{{cite journal  | author=Romkes M, Faletto MB, Blaisdell JA, ''et al.'' |title=Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily. |journal=Biochemistry |volume=32 |issue= 5 |pages= 1390 |year= 1993 |pmid= 8095407 |doi= }}
* {{cite journal | vauthors = Smith G, Stubbins MJ, Harries LW, Wolf CR | title = Molecular genetics of the human cytochrome P450 monooxygenase superfamily | journal = Xenobiotica | volume = 28 | issue = 12 | pages = 1129–65 | date = December 1998 | pmid = 9890157 | doi = 10.1080/004982598238868 }}
*{{cite journal | author=Goldstein JA, Faletto MB, Romkes-Sparks M, ''et al.'' |title=Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. |journal=Biochemistry |volume=33 |issue= 7 |pages= 1743-52 |year= 1994 |pmid= 8110777 |doi= }}
* {{cite journal | vauthors = Ged C, Beaune P | title = Partial sequence and polymerase chain reaction-mediated analysis of expression of the human CYP2C18 gene | journal = Pharmacogenetics | volume = 2 | issue = 3 | pages = 109–15 | date = June 1992 | pmid = 1306110 | doi = 10.1097/00008571-199206000-00002 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA | title = Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily | journal = Biochemistry | volume = 32 | issue = 5 | pages = 1390 | date = February 1993 | pmid = 8095407 | doi = 10.1021/bi00056a025 }}
*{{cite journal | author=de Morais SM, Schweikl H, Blaisdell J, Goldstein JA |title=Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. |journal=Biochem. Biophys. Res. Commun. |volume=194 |issue= 1 |pages= 194-201 |year= 1993 |pmid= 8333835 |doi= }}
* {{cite journal | vauthors = Goldstein JA, Faletto MB, Romkes-Sparks M, Sullivan T, Kitareewan S, Raucy JL, Lasker JM, Ghanayem BI | title = Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans | journal = Biochemistry | volume = 33 | issue = 7 | pages = 1743–52 | date = February 1994 | pmid = 8110777 | doi = 10.1021/bi00173a017 }}
*{{cite journal | author=Richardson TH, Griffin KJ, Jung F, ''et al.'' |title=Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51. |journal=Arch. Biochem. Biophys. |volume=338 |issue= 2 |pages= 157-64 |year= 1997 |pmid= 9028867 |doi= 10.1006/abbi.1996.9817 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Zaphiropoulos PG |title=Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 2985-93 |year= 1997 |pmid= 9154796 |doi=  }}
* {{cite journal | vauthors = de Morais SM, Schweikl H, Blaisdell J, Goldstein JA | title = Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18 | journal = Biochemical and Biophysical Research Communications | volume = 194 | issue = 1 | pages = 194–201 | date = July 1993 | pmid = 8333835 | doi = 10.1006/bbrc.1993.1803 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Richardson TH, Griffin KJ, Jung F, Raucy JL, Johnson EF | title = Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51 | journal = Archives of Biochemistry and Biophysics | volume = 338 | issue = 2 | pages = 157–64 | date = February 1997 | pmid = 9028867 | doi = 10.1006/abbi.1996.9817 }}
*{{cite journal | author=Macé K, Bowman ED, Vautravers P, ''et al.'' |title=Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. |journal=Eur. J. Cancer |volume=34 |issue= 6 |pages= 914-20 |year= 1998 |pmid= 9797707 |doi= }}
* {{cite journal | vauthors = Zaphiropoulos PG | title = Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis | journal = Molecular and Cellular Biology | volume = 17 | issue = 6 | pages = 2985–93 | date = June 1997 | pmid = 9154796 | pmc = 232150 | doi =  10.1128/mcb.17.6.2985}}
*{{cite journal | author=Klose TS, Blaisdell JA, Goldstein JA |title=Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. |journal=J. Biochem. Mol. Toxicol. |volume=13 |issue= 6 |pages= 289-95 |year= 1999 |pmid= 10487415 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Finta C, Zaphiropoulos PG |title=The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. |journal=Genomics |volume=63 |issue= 3 |pages= 433-8 |year= 2000 |pmid= 10704292 |doi= 10.1006/geno.1999.6063 }}
* {{cite journal | vauthors = Macé K, Bowman ED, Vautravers P, Shields PG, Harris CC, Pfeifer AM | title = Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues | journal = European Journal of Cancer | volume = 34 | issue = 6 | pages = 914–20 | date = May 1998 | pmid = 9797707 | doi = 10.1016/S0959-8049(98)00034-3 }}
*{{cite journal | author=Thum T, Borlak J |title=Gene expression in distinct regions of the heart. |journal=Lancet |volume=355 |issue= 9208 |pages= 979-83 |year= 2000 |pmid= 10768437 |doi= }}
* {{cite journal | vauthors = Klose TS, Blaisdell JA, Goldstein JA | title = Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs | journal = Journal of Biochemical and Molecular Toxicology | volume = 13 | issue = 6 | pages = 289–95 | year = 1999 | pmid = 10487415 | doi = 10.1002/(SICI)1099-0461(1999)13:6<289::AID-JBT1>3.0.CO;2-N }}
*{{cite journal | author=Marill J, Cresteil T, Lanotte M, Chabot GG |title=Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1341-8 |year= 2001 |pmid= 11093772 |doi=  }}
* {{cite journal | vauthors = Finta C, Zaphiropoulos PG | title = The human CYP2C locus: a prototype for intergenic and exon repetition splicing events | journal = Genomics | volume = 63 | issue = 3 | pages = 433–8 | date = February 2000 | pmid = 10704292 | doi = 10.1006/geno.1999.6063 }}
*{{cite journal | author=Zhu-Ge J, Yu YN, Qian YL, Li X |title=Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing. |journal=World J. Gastroenterol. |volume=8 |issue= 5 |pages= 888-92 |year= 2003 |pmid= 12378636 |doi=  }}
* {{cite journal | vauthors = Thum T, Borlak J | title = Gene expression in distinct regions of the heart | journal = Lancet | volume = 355 | issue = 9208 | pages = 979–83 | date = March 2000 | pmid = 10768437 | doi = 10.1016/S0140-6736(00)99016-0 }}
}}
* {{cite journal | vauthors = Marill J, Cresteil T, Lanotte M, Chabot GG | title = Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites | journal = Molecular Pharmacology | volume = 58 | issue = 6 | pages = 1341–8 | date = December 2000 | pmid = 11093772 | doi =  }}
* {{cite journal | vauthors = Zhu-Ge J, Yu YN, Qian YL, Li X | title = Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing | journal = World Journal of Gastroenterology | volume = 8 | issue = 5 | pages = 888–92 | date = October 2002 | pmid = 12378636 | doi =  10.3748/wjg.v8.i5.888}}
{{refend}}
{{refend}}
{{Cytochrome P450}}


{{SIB}}


{{WS}}
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{{WikiDoc Sources}}

Latest revision as of 01:59, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.[1][2][3]

Function

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.[3]

CYP2C18 also possesses epoxygenase activitiy: it can attack various long-chain polyunsaturated fatty acids at their double (i.e. alkene) bonds to form epoxide products that act as signaling agents. It metabolizes: 1) arachidonic acid to various epoxyeicosatrienoic acids (also termed EETs); 2) linoleic acid to 9,10-epoxy octadecaenoic acids (also termed vernolic acid, linoleic acid 9:10-oxide, or leukotoxin) and 12,13-epoxy-octadecaenoic (also termed coronaric acid, linoleic acid 12,13-oxide, or isoleukotoxin); 3) docosohexaenoic acid to various epoxydocosapentaenoic acids (also termed EDPs); and 4) eicosapentaenoic acid to various epoxyeicosatetraenoic acids (also termed EEQs).[4][5][6]

While CYP2C19, CYP2C8, CYP2C9, CYP2J2, and possibly CYP2S1 are the main producers of EETs and, very likely EEQs, EDPs, and the epoxides of linoleic acid, CYP2C18 may contribute to the production of these metabolites in certain tissues.[5][7]

References

  1. ↑ Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ (September 1991). "Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA". Molecular Pharmacology. 40 (3): 375–82. PMID 1896026.
  2. ↑ Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (April 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry. 30 (13): 3247–55. doi:10.1021/bi00227a012. PMID 2009263.
  3. ↑ 3.0 3.1 "Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18".
  4. ↑ Fleming I (October 2014). "The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease". Pharmacological Reviews. 66 (4): 1106–40. doi:10.1124/pr.113.007781. PMID 25244930.
  5. ↑ 5.0 5.1 Wagner K, Vito S, Inceoglu B, Hammock BD (October 2014). "The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling". Prostaglandins & Other Lipid Mediators. 113-115: 2–12. doi:10.1016/j.prostaglandins.2014.09.001. PMC 4254344. PMID 25240260.
  6. ↑ Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH (March 2014). "Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway". Journal of Lipid Research. 55 (6): 1150–1164. doi:10.1194/jlr.M047357. PMC 4031946. PMID 24634501.
  7. ↑ Spector AA, Kim HY (April 2015). "Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism". Biochimica et Biophysica Acta. 1851 (4): 356–65. doi:10.1016/j.bbalip.2014.07.020. PMC 4314516. PMID 25093613.

External links

Further reading


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