Addison's disease history and symptoms: Difference between revisions

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{{CMG}} ; {{AE}} {{ADG}}
{{CMG}} ; {{AE}} {{ADG}}
==Overview==
==Overview==
Addison's disease often has an insidious onset. In many cases, the disease is only recognized when the patient presents with an acute crisis precipitated by a stressful [[illness]] or situation. Acute adrenal insufficiency should be considered in patients presenting with [[abdominal pain]], [[nausea]], [[diarrhea]], [[hypotension]], and [[fever]]. A detailed and thorough history is necessary. Specific areas of focus when obtaining a history from the patient of Addison's disease include recent changes in diet, any signs of [[postural hypotension]] and history of [[cancer]] or other autoimmune diseases, [[tuberculosis]] or any exposure to anyone who has been diagnosed with [[tuberculosis]].


==History and Symptoms==
==History==
===Symptoms===
A detailed and thorough history from the patient is necessary. Specific areas of focus when obtaining a history from the patient of Addison's disease include:<ref name="pmid22907517">{{cite journal |vauthors=Quinkler M |title=[Addison's disease] |language=German |journal=Med Klin Intensivmed Notfmed |volume=107 |issue=6 |pages=454–9 |year=2012 |pmid=22907517 |doi=10.1007/s00063-012-0112-3 |url=}}</ref>
Characteristics of the disease are:
*Recent changes in diet
**Patients with Addison disease often crave salty foods and are often [[Anorexia|anorexic]]
*Irregular [[menstruation]]
**[[Oligomenorrhea]] or [[amenorrhea]] are features of Addison disease
*Any signs of [[postural hypotension]]
*Any recent changes in [[weight]]
*History of [[tuberculosis]] or any exposure to someone with [[tuberculosis]]
*History of [[malignancy]]
*History of other [[autoimmune disease]], such as [[Graves' disease|Graves disease]], [[Hashimoto's thyroiditis]], [[hypoparathyroidism]], [[vitiligo]], [[pernicious anemia]] or [[diabetes mellitus]]
*[[Family history]] of Addison's disease or any other [[Adrenal gland|adrenal]] disorder


{| class="wikitable"
==Symptoms==
!Type of presentation
Addison's disease often has an insidious onset. In many cases the disease is only recognized when the patient presents with an acute crisis precipitated by a stressful illness. Acute adrenal insufficiency should be considered in patients presenting with [[abdominal pain]], [[nausea]], [[diarrhea]], [[hypotension]] and [[fever]].<ref name="pmid23633816">{{cite journal |vauthors=Sarkar SB, Sarkar S, Ghosh S, Bandyopadhyay S |title=Addison's disease |journal=Contemp Clin Dent |volume=3 |issue=4 |pages=484–6 |year=2012 |pmid=23633816 |pmc=3636818 |doi=10.4103/0976-237X.107450 |url=}}</ref><ref name="pmid12788587">{{cite journal |vauthors=Arlt W, Allolio B |title=Adrenal insufficiency |journal=Lancet |volume=361 |issue=9372 |pages=1881–93 |year=2003 |pmid=12788587 |doi=10.1016/S0140-6736(03)13492-7 |url=}}</ref>
!Harmone deficiency
===Common Symptoms===
!Common symptoms
*[[Weakness]]
!Less common symptoms
*[[Fatigue|Chronic fatigue]]
|-
*[[Weight loss]]
|Acute adrenal insufficiency  
*[[Anorexia]]
|Mainly cortisol
*[[Nausea]]
|
*[[Vomiting]]
* Sudden penetrating pain in the lower back, abdomen, or legs
*[[Diarrhea]]
* Severe [[vomiting]] and [[diarrhea]]
*Intolerance of temperature extremes
* [[Dehydration]]
*[[Abdominal pain]]
* Low blood pressure - [[dizziness]] and [[fainting]]
*[[Amenorrhea]]
* [[Loss of consciousness]]
*Craving for salty foods
|In acute adrenal hemorrhage,  
*[[Depression]]
* Deteriorates with sudden collapse,
*[[Dizziness]]
* Abdominal or flank pain,  
===Symptoms of Addisonian crisis===
* Nausea with or without hyperpyrexia.
Symptoms of Addisonian crisis include:
|-
*[[Dizziness]], [[generalized weakness]] ([[fatigue]])
| rowspan="2" |Chronic adrenal insufficiency
*[[Anorexia]]
|Primary: Both glucocorticoid, mineralocorticoid
*Sharp, sudden [[pain]] in the [[abdomen]], [[legs]], or [[lower back]]
| rowspan="2" |
*Severe [[vomiting]] and [[diarrhea]]
* Hyperpigmentation (prominent on the sun-exposed areas of the skin, extensor surfaces, knuckles, elbows, knees)
*[[Dehydration]]
* Progressive weakness, fatigue, poor appetite, and weight loss.
*Loss of [[consciousness]]
* Nausea, vomiting, and occasional diarrhea.
*[[Hypoglycemia]]
* [[Myalgia|Muscle pains]]
* [[Arthralgia|Joint pains]]
 
| rowspan="2" |
|-
|Secondary: Glucorticoid
|}
 
 
{| class="wikitable"
!Symptoms
!Pathophysiology
!
!
|-
|Hyperpigmentation
|Stimulant effect of excess ACTH on the melanocytes to produce melanin
|
|
|-
|Dizziness with orthostasis
|
* Volume depletion, loss of the mineralocorticoid effect of aldosterone,  
 
* Loss of the permissive effect of cortisol in enhancing the vasopressor effect of the catecholamines.
|
|
|-
|Myalgias and flaccid muscle paralysis
|Hyperkalemia
|
|
|-
|Amenorrhea
|Combined effect of weight loss and chronic ill health or secondary to premature autoimmune ovarian failure
|
|
|}


==References==
==References==

Latest revision as of 20:13, 11 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

Addison's disease often has an insidious onset. In many cases, the disease is only recognized when the patient presents with an acute crisis precipitated by a stressful illness or situation. Acute adrenal insufficiency should be considered in patients presenting with abdominal pain, nausea, diarrhea, hypotension, and fever. A detailed and thorough history is necessary. Specific areas of focus when obtaining a history from the patient of Addison's disease include recent changes in diet, any signs of postural hypotension and history of cancer or other autoimmune diseases, tuberculosis or any exposure to anyone who has been diagnosed with tuberculosis.

History

A detailed and thorough history from the patient is necessary. Specific areas of focus when obtaining a history from the patient of Addison's disease include:[1]

Symptoms

Addison's disease often has an insidious onset. In many cases the disease is only recognized when the patient presents with an acute crisis precipitated by a stressful illness. Acute adrenal insufficiency should be considered in patients presenting with abdominal pain, nausea, diarrhea, hypotension and fever.[2][3]

Common Symptoms

Symptoms of Addisonian crisis

Symptoms of Addisonian crisis include:

References

  1. Quinkler M (2012). "[Addison's disease]". Med Klin Intensivmed Notfmed (in German). 107 (6): 454–9. doi:10.1007/s00063-012-0112-3. PMID 22907517.
  2. Sarkar SB, Sarkar S, Ghosh S, Bandyopadhyay S (2012). "Addison's disease". Contemp Clin Dent. 3 (4): 484–6. doi:10.4103/0976-237X.107450. PMC 3636818. PMID 23633816.
  3. Arlt W, Allolio B (2003). "Adrenal insufficiency". Lancet. 361 (9372): 1881–93. doi:10.1016/S0140-6736(03)13492-7. PMID 12788587.

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