Addison's disease epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

The prevalence of Addison's disease in the human population is estimated to be roughly 4-12 persons per 100,000 persons. The incidence of Addison's disease is approximately 0.6 per 100,000 individuals worldwide. Addison's disease can affect any age range. Addison's disease occurs more frequently in females as compared to males with a ratio of 12.3 to 1.

Epidemiology

Prevalence

The prevalence of Addison's disease in the human population is sometimes estimated at roughly 4-12 people per 100,000 persons.

Incidence

The incidence Addison's disease is approximately 0.6 per 100,000 individuals worldwide.

Demographics

Age

  • Addison disease can affect any age range.
  • Addison's disease typically presents in adults between 30 and 50 years of age as most are often diagnosed with autoimmune-associated diseases.[1]

Gender

Addison's disease occur more frequently in females as compared to males with a ratio of 12.3 to 1. [2]

Race

There is no racial predilection to Addison's disease.

Geographical distrubution

Addison's disease may be more common in areas where systemic fungal infections such as histoplasmosis can cause destruction of the adrenal cortex by disseminated infection or secondary to antifungal medications.

References

  1. Michels AW, Eisenbarth GS (2010). "Immunologic endocrine disorders". J. Allergy Clin. Immunol. 125 (2 Suppl 2): S226–37. doi:10.1016/j.jaci.2009.09.053. PMC 2835296. PMID 20176260.
  2. Jacobson DL, Gange SJ, Rose NR, Graham NM (1997). "Epidemiology and estimated population burden of selected autoimmune diseases in the United States". Clin Immunol Immunopathol. 84 (3): 223–43. PMID 9281381.



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