Addison's disease causes

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Addison's disease Microchapters


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]


Common causes of Addison's disease include autoimmune, tuberculosis, AIDS, CMV, hemorrhage, infarction, sarcoidosis and infections.


Life-threatening Causes

Life-threatening causes of Addison's disease include:

Common Causes

Common causes of Addison's disease include:[2]

Less common causes

Less common causes of Addison's disease include:

Causes by Organ System

Cardiovascular Arteritis, Hypotension, Hemorrhage, Infarction
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Corticosteroid withdrawal, Pasireotide
Ear Nose Throat No underlying causes
Endocrine Adrenal aplasia / hypoplasia, Adrenal metastases, After surgery of cortisol-secreting tumor, Bilateral adrenalectomy , Congenital adrenal hyperplasia, Glucocorticoid deficiency 1
Environmental No underlying causes
Gastroenterologic Hemochromatosis
Genetic No underlying causes
Hematologic Anticoagulation, Coagulopathy , Embolus, Leukemia, Lymphoma , Thrombosis
Iatrogenic Iatrogenic, Radiation therapy
Infectious Disease AIDS, Blastomycosis, CMV, Coccidiomycosis, Cryptococcosis, Histoplasmosis , Mycobacterium avium intracellulaire (MAI), Sepsis, Syphilis, Toxoplasmosis, Tuberculosis, Waterhouse-Friderichson syndrome
Musculoskeletal / Ortho No underlying causes
Neurologic Adrenoleukodystrophy, Coma
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Kaposi's sarcoma, Leukemia, Lymphoma
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Sarcoidosis,
Renal / Electrolyte Uremia, Waterhouse-Friderichson syndrome
Rheum / Immune / Allergy Autoimmune, Sarcoidosis
Sexual No underlying causes
Trauma Trauma
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Amyloidosis, Idiopathic, Iatrogenic, Radiation therapy, Surgery

Causes in Alphabetical Order


  1. LaBan MM, Whitmore CE, Taylor RS (2003). "Bilateral adrenal hemorrhage after anticoagulation prophylaxis for bilateral knee arthroplasty". Am J Phys Med Rehabil. 82 (5): 418–20. doi:10.1097/01.PHM.0000064741.97586.E4. PMID 12704285.
  2. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:14-15