Acute myeloid leukemia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

  • The term 'cancer' was first used by Galen dating back to 130–200 AD.
  • After the advent of microscopy to detect hematological disorders, especially work by the pioneering microscopist Anton van Leeuwenhoek significant progress was made to help diagnose various malignancies.
  • Van Leeuwenhoek was the first scientist to describe red blood cells. in 1674.
  • In 1749, Joseph Lieutaud, a French anatomist described what he called 'the globuli albicantes’, which later came to be known as white blood cells.
  • During the same year, after De Sanc described ‘globules blancs du pus’, it became known that pus and inflammation were related to blood.
  • In 1774, William Hewson gave a detailed description of the lymphatic system and lymphocytes.
  • There was no account of leukemia in the literature to reveal any clinical cases before the nineteenth century.
  • In 1846, Dr Henry Fuller, a physician at St George's Hospital in London published the first case report of chronic granulocytic leukemia. This was the first recorded use of the microscope to diagnose leukemia in a living patient. He noted that the time from the onset of ill health to death was 8 months. He labelled his diagnosis as leucocythaemia

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