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{{Acute myeloid leukemia}}
{{Acute myeloid leukemia}}


{{CMG}}; {{AE}}
{{CMG}}; {{AE}} {{shyam}}


==Overview==
==Overview==


==Historical Perspective==
==Historical Perspective==
* The term 'cancer' was first used by Galen dating back to 130–200 AD.
*In '''130-200 AD''', Galen first used the term 'cancer.' This included hematologic and solid malignancies.
* After the advent of microscopy to detect hematological disorders, especially work by the pioneering microscopist Anton van Leeuwenhoek significant progress was made to help diagnose various malignancies.
*In '''1674''', Van Leeuwenhoek was the first scientist to describe [[red blood cells]].
* Van Leeuwenhoek was the first scientist to describe red blood cells. in 1674.
*In '''1749''', Joseph Lieutaud, a French anatomist, described what he called 'the globuli albicantes’, which later came to be known as [[white blood cells]].
* In 1749, Joseph Lieutaud, a French anatomist described what he called 'the globuli albicantes’, which later came to be known as white blood cells.
*In '''1749''', after De Sanc described ‘globules blancs du pus’, it became known that pus and inflammation were related to blood.
* During the same year, after De Sanc described ‘globules blancs du pus’, it became known that pus and inflammation were related to blood.
*In '''1774''', William Hewson gave a detailed description of the lymphatic system and lymphocytes.
* In 1774, William Hewson gave a detailed description of the lymphatic system and lymphocytes.
*In '''1846''', Dr. Henry Fuller, a physician at St George's Hospital in London, published the first case report of chronic granulocytic leukemia. This was the first recorded use of the microscope to diagnose leukemia in a patient. He noted that the time from the onset of ill health to death was 8 months. He labelled his diagnosis as leucocythaemia.
* There was no account of leukemia in the literature to reveal any clinical cases before the nineteenth century.
*In '''1857''', Nikolaus Friedreich documented the first case of acute leukemia.<ref name="pmid29340131">{{cite journal| author=Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C| title=Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis. | journal=Int J Hematol Oncol Stem Cell Res | year= 2017 | volume= 11 | issue= 4 | pages= 328-339 | pmid=29340131 | doi= | pmc=5767295 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340131  }} </ref>
* In 1846, Dr Henry Fuller, a physician at St George's Hospital in London published the first case report of chronic granulocytic leukemia. This was the first recorded use of the microscope to diagnose leukemia in a living patient. He noted that the time from the onset of ill health to death was 8 months. He labelled his diagnosis as leucocythaemia
*In '''1877''', Paul Ehrlich performed polychromatophilic stains to classify leukemia into myeloid or lymphoid.<ref name="pmid29340131">{{cite journal| author=Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C| title=Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis. | journal=Int J Hematol Oncol Stem Cell Res | year= 2017 | volume= 11 | issue= 4 | pages= 328-339 | pmid=29340131 | doi= | pmc=5767295 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340131  }} </ref>
*In '''1878''', Ernst Neumann described the bone marrow as the origin of leukemia.<ref name="pmid29340131">{{cite journal| author=Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C| title=Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis. | journal=Int J Hematol Oncol Stem Cell Res | year= 2017 | volume= 11 | issue= 4 | pages= 328-339 | pmid=29340131 | doi= | pmc=5767295 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340131  }} </ref>
*In '''1889''', Willhelm Ebstein described leukemia as a fast and fatal disease.<ref name="pmid29340131">{{cite journal| author=Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C| title=Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis. | journal=Int J Hematol Oncol Stem Cell Res | year= 2017 | volume= 11 | issue= 4 | pages= 328-339 | pmid=29340131 | doi= | pmc=5767295 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340131  }} </ref>
*In '''1900''', Otto Naegeli described the differences between blasts (blood cancer cells) of myeloid versus lymphoid origin.<ref name="pmid29340131">{{cite journal| author=Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C| title=Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis. | journal=Int J Hematol Oncol Stem Cell Res | year= 2017 | volume= 11 | issue= 4 | pages= 328-339 | pmid=29340131 | doi= | pmc=5767295 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340131  }} </ref>
*In '''1914''', Theodor Boveri described the role of chromosomal aberrations in the development of cancer. This later became very important to the classification of acute myeloid leukemia, which is largely based on chromosomal abnormalities.<ref name="pmid29340131">{{cite journal| author=Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C| title=Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis. | journal=Int J Hematol Oncol Stem Cell Res | year= 2017 | volume= 11 | issue= 4 | pages= 328-339 | pmid=29340131 | doi= | pmc=5767295 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29340131  }} </ref>
*In '''2017''', the European Leukemia Net (ELN) classification system was devised to help risk stratify patients with acute myeloid leukemia.


*


==References==
==References==

Revision as of 21:22, 22 October 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]

Overview

Historical Perspective

  • In 130-200 AD, Galen first used the term 'cancer.' This included hematologic and solid malignancies.
  • In 1674, Van Leeuwenhoek was the first scientist to describe red blood cells.
  • In 1749, Joseph Lieutaud, a French anatomist, described what he called 'the globuli albicantes’, which later came to be known as white blood cells.
  • In 1749, after De Sanc described ‘globules blancs du pus’, it became known that pus and inflammation were related to blood.
  • In 1774, William Hewson gave a detailed description of the lymphatic system and lymphocytes.
  • In 1846, Dr. Henry Fuller, a physician at St George's Hospital in London, published the first case report of chronic granulocytic leukemia. This was the first recorded use of the microscope to diagnose leukemia in a patient. He noted that the time from the onset of ill health to death was 8 months. He labelled his diagnosis as leucocythaemia.
  • In 1857, Nikolaus Friedreich documented the first case of acute leukemia.[1]
  • In 1877, Paul Ehrlich performed polychromatophilic stains to classify leukemia into myeloid or lymphoid.[1]
  • In 1878, Ernst Neumann described the bone marrow as the origin of leukemia.[1]
  • In 1889, Willhelm Ebstein described leukemia as a fast and fatal disease.[1]
  • In 1900, Otto Naegeli described the differences between blasts (blood cancer cells) of myeloid versus lymphoid origin.[1]
  • In 1914, Theodor Boveri described the role of chromosomal aberrations in the development of cancer. This later became very important to the classification of acute myeloid leukemia, which is largely based on chromosomal abnormalities.[1]
  • In 2017, the European Leukemia Net (ELN) classification system was devised to help risk stratify patients with acute myeloid leukemia.


References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Lagunas-Rangel FA, Chávez-Valencia V, Gómez-Guijosa MÁ, Cortes-Penagos C (2017). "Acute Myeloid Leukemia-Genetic Alterations and Their Clinical Prognosis". Int J Hematol Oncol Stem Cell Res. 11 (4): 328–339. PMC 5767295. PMID 29340131.

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