GRIN2A

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A
PDB rendering based on 2a5s.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2a5s​, 2a5t​
Identifiers
Symbols	GRIN2A ; NMDAR2A; NR2A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 645
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A, also known as GRIN2A, is a human gene.

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

See also

• Glutamate receptor
• NMDA receptor

Further reading

• Schröder HC, Perovic S, Kavsan V; et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.CS1 maint: Multiple names: authors list (link)
• Monyer H, Sprengel R, Schoepfer R; et al. (1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. PMID 1350383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. PMID 7569905.CS1 maint: Multiple names: authors list (link)
• Magnuson DS, Knudsen BE, Geiger JD; et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakimura K, Kutsuwada T, Ito I; et al. (1995). "Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit". Nature. 373 (6510): 151–5. doi:10.1038/373151a0. PMID 7816096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foldes RL, Adams SL, Fantaske RP, Kamboj RK (1994). "Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein". Biochim. Biophys. Acta. 1223 (1): 155–9. PMID 8061049.CS1 maint: Multiple names: authors list (link)
• Sheng M, Cummings J, Roldan LA; et al. (1994). "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex". Nature. 368 (6467): 144–7. doi:10.1038/368144a0. PMID 8139656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.CS1 maint: Multiple names: authors list (link)
• Takano H, Onodera O, Tanaka H; et al. (1994). "Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel". Biochem. Biophys. Res. Commun. 197 (2): 922–6. PMID 8267632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lannuzel A, Lledo PM, Lamghitnia HO; et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. PMID 8563977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corasaniti MT, Melino G, Navarra M; et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 4 (3): 315–21. PMID 8581564.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Niethammer M, Kim E, Sheng M (1996). "Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases". J. Neurosci. 16 (7): 2157–63. PMID 8601796.CS1 maint: Multiple names: authors list (link)
• Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. PMID 8724036.CS1 maint: Multiple names: authors list (link)
• Hess SD, Daggett LP, Crona J; et al. (1996). "Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors". J. Pharmacol. Exp. Ther. 278 (2): 808–16. PMID 8768735.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu P, Price P, Du B; et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". Neuroreport. 7 (5): 1045–9. PMID 8804048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1–2): 168–76. PMID 8821747.CS1 maint: Multiple names: authors list (link)
• Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. PMID 8822372.CS1 maint: Multiple names: authors list (link)
• Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. PMID 8845955.
• Raber J, Toggas SM, Lee S; et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.