P2RX5

Purinergic receptor P2X, ligand-gated ion channel, 5
Identifiers
Symbol(s)	P2RX5; MGC47755; P2X5; P2X5R
External IDs	OMIM: 602836 MGI: 2137026 Homologene: 1924
Gene ontology Molecular Function: • receptor activity • ion channel activity • ATP binding Cellular Component: • membrane • integral to membrane Biological Process: • ion transport
Orthologs
	Human	Mouse
Entrez	5026	94045
Ensembl	na	ENSMUSG00000005950
Refseq	NM_002561 (mRNA) NP_002552 (protein)	NM_033321 (mRNA) NP_201578 (protein)
Location	na	Chr 11: 72.98 - 72.99 Mb
Pubmed search	[1]	[2]

Purinergic receptor P2X, ligand-gated ion channel, 5, also known as P2RX5, is a human gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.

See also

• P2X receptor

Further reading

• North RA (2002). "Molecular physiology of P2X receptors.". Physiol. Rev. 82 (4): 1013-67. doi:10.1152/physrev.00015.2002. PMID 12270951.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
• Lê KT, Paquet M, Nouel D, et al. (1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system.". FEBS Lett. 418 (1-2): 195-9. PMID 9414125.
• Touchman JW, Anikster Y, Dietrich NL, et al. (2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.". Genome Res. 10 (2): 165-73. PMID 10673275.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
• Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007-15. PMID 12787128.
• Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.". J. Invest. Dermatol. 121 (2): 315-27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• de Rijke B, van Horssen-Zoetbrood A, Beekman JM, et al. (2006). "A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia.". J. Clin. Invest. 115 (12): 3506-16. doi:10.1172/JCI24832. PMID 16322791.
• Metcalfe MJ, Baker DM, Burnstock G (2007). "Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency.". Arch. Dermatol. Res. 298 (6): 301-7. doi:10.1007/s00403-006-0693-x. PMID 16967306.
• Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G (2007). "P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate.". J. Biol. Chem. 281 (51): 39561-72. doi:10.1074/jbc.M606113200. PMID 17001079.

External links

• MeSH P2RX5+protein,+human

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.