Hexobarbital: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
No edit summary
Line 1: Line 1:
{{SI}}
{{EH}}
{{drugbox
{{drugbox
| IUPAC_name = 5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione
| IUPAC_name = 5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione
Line 29: Line 25:
| routes_of_administration =  
| routes_of_administration =  
}}
}}
{{SI}}
{{CMG}}
{{EH}}


==Overview==
==Overview==

Revision as of 14:35, 18 June 2009

Hexobarbital
Clinical data
ATC code
Pharmacokinetic data
Protein binding25%
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC12H16N2O3
Molar mass236.267 g/mol

WikiDoc Resources for Hexobarbital

Articles

Most recent articles on Hexobarbital

Most cited articles on Hexobarbital

Review articles on Hexobarbital

Articles on Hexobarbital in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Hexobarbital

Images of Hexobarbital

Photos of Hexobarbital

Podcasts & MP3s on Hexobarbital

Videos on Hexobarbital

Evidence Based Medicine

Cochrane Collaboration on Hexobarbital

Bandolier on Hexobarbital

TRIP on Hexobarbital

Clinical Trials

Ongoing Trials on Hexobarbital at Clinical Trials.gov

Trial results on Hexobarbital

Clinical Trials on Hexobarbital at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Hexobarbital

NICE Guidance on Hexobarbital

NHS PRODIGY Guidance

FDA on Hexobarbital

CDC on Hexobarbital

Books

Books on Hexobarbital

News

Hexobarbital in the news

Be alerted to news on Hexobarbital

News trends on Hexobarbital

Commentary

Blogs on Hexobarbital

Definitions

Definitions of Hexobarbital

Patient Resources / Community

Patient resources on Hexobarbital

Discussion groups on Hexobarbital

Patient Handouts on Hexobarbital

Directions to Hospitals Treating Hexobarbital

Risk calculators and risk factors for Hexobarbital

Healthcare Provider Resources

Symptoms of Hexobarbital

Causes & Risk Factors for Hexobarbital

Diagnostic studies for Hexobarbital

Treatment of Hexobarbital

Continuing Medical Education (CME)

CME Programs on Hexobarbital

International

Hexobarbital en Espanol

Hexobarbital en Francais

Business

Hexobarbital in the Marketplace

Patents on Hexobarbital

Experimental / Informatics

List of terms related to Hexobarbital

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital was also marketed as a rapid-acting sleeping pill with short duration (tradenames: Citopan, Evipan and others, usually in 250 mg strength tablets). Hexobarbital is still used in some scientific research.

Further reading

  • Takenoshita R, Toki S (2004). "[New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]". Yakugaku Zasshi. 124 (12): 857–71. PMID 15577260.
  • Wahlström G (1998). "A study of the duration of acute tolerance induced with hexobarbital in male rats". Pharmacol Biochem Behav. 59 (4): 945–8. PMID 9586853.
  • Korkmaz S, Ljungblad E, Wahlström G (1995). "Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat". Brain Res. 676 (2): 371–7. PMID 7614008.
  • Dall V, Orntoft U, Schmidt A, Nordholm L (1993). "Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital". Pharmacol Biochem Behav. 46 (1): 73–6. PMID 8255925.

Template:Barbiturates Template:General anesthetics

Template:SIB

de:Hexobarbital fi:Heksobarbitaali Template:WikiDoc Sources Template:WH