Mecloqualone
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| Mecloqualone
| |
| Systematic (IUPAC) name | |
| 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C15H11ClN2O |
| Mol. mass | 270.714 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Mecloqualone (Nubarene, Casfen) is an analogue of methaqualone which was first made in 1960 [1] and marketed mainly in France and some other European countries. It has sedative, hypnotic and anxiolytic properties, and was used for the treatment of insomnia. [2] Mecloqualone is faster acting but shorter lasting than methaqualone and so was used only as a sleeping pill[3], in contrast to methaqualone which was used as a general purpose anxiolytic as well. Mecloqualone was never as widely used as methaqualone and is no longer prescribed because of concerns about its potential for abuse and overdose.
See also
References
- ↑ Jackman GV, Petrow V, Stephenson O. Journal of Pharmacy and Pharmacology 1960; 12(9):528-9.
- ↑ Mouren P, Giraud F, Pinsard N. "Clinical use of a new psycholeptic: Mecloqualone." (French) Marseille Medical 1963;100: 599-602. PMID 13936358
- ↑ Dubnk B, Towne CA, Bush MT. "Detection, assay and rate of excretion of mecloqualone in animals and man." Toxicology and Applied Pharmacology 1969 Nov;15(3):632-41. PMID 5353825
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