Interstitial nephritis
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| Interstitial nephritis Classification and external resources | |
| ICD-10 | N10.-N12. |
|---|---|
| ICD-9 | 580.89, 581.89, 582.89, 583.89 |
| DiseasesDB | 6854 |
| MedlinePlus | 000464 |
| eMedicine | med/1596 |
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Interstitial nephritis (or Tubulo-interstitial nephritis) is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules. This disease can be either acute, which means it occurs suddenly or chronic, meaning it is ongoing and eventually ending in kidney failure.
Etiologies
Common causes include infection, or reaction to medication (such as an analgesic or antibiotics). 71%[1] to 92%[2] of cases are reported to be caused by drugs. This disease is also caused by other diseases and toxins that do damage to the kidney. Both acute and chronic tubulointerstitial nephritis can be caused by a bacterial infection in the kidneys, known as pyelonephritis. The most common cause is by an allergic reaction to a drug. The drugs that are known to cause this sort of reaction are antibiotics such as penicillin, and nonsteroidal anti-inflammatory drugs, such as aspirin. The time between exposure to the drug and the development of acute tubulointerstitial nephritis can be anywhere from 5 days to 5 weeks.
Diagnosis
At times there are no symptoms of this disease, but when they do occur they are widely varied and can occur rapidly or gradually[3][1][4][5][6]. When caused by an allergic reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients)[1], rash (15% of patients)[1], and enlarged kidneys. Some people experience dysuria, and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include hyperkalemia, metabolic acidosis, and kidney failure.
Blood tests
About 23% of patients have eosinophilia[1].
Urinary findings
Urinary findings include:
- Eosinophiluria: sensitivity is 67% and specificity is 83% [3][7]. The sensitivity is higher in patients with interstitial nephritis induced by methicillin or when the Hansel's stain is used.
- Isosthenuria [8]
Gallium scan
The sensitivity of an abnormal gallium scan has been reported to range from 60%[9] to 100%[10].
Treatment
Remove the etiology such as an offending drug. Corticosteroids do not clearly help [2]. Nutrition therapy consists of adequate fluid intake, which can require several liters of extra fluid. "39", in Alexopolos Y: Krause's Food, Nutrition, & Diet Therapy, 11th (in English), Philadelphia Pennsylvania: Saunders, 968. ISBN 0-7216-9784-4.
Prognosis
The kidneys are the only body system that is directly affected by tubulointerstitial nephritis. Kidney function is usually reduced; the kidneys can be just slightly dysfunctional, or fail completely.
In chronic tubulointerstitial nephritis the most serious long term effect is kidney failure. When the proximal tube is injured sodium, potassium, bicarbonate, uric acid, and phosphate intake may be reduced or changed, resulting in low bicarbonate, known as metabolic acidosis, low potassium, low uric acid known as hypouricemia, and low phosphate known as hypophosphatemia. Damage to the distal tubule may cause loss of urine concentrating ability and polyuria.
In most cases of acute tubulointerstitial nephritis, the function of the kidneys will return after the harmful drug is not taken anymore, or when the underlying disease is cured by treatment. If the illness is caused by an allergic reaction, a corticosteroid may speed the recovery kidney function, however this is often not the case. Chronic tubulointerstitial nephritis has no cure. Some patients may require dialysis. Eventually, a kidney transplant may be needed.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Baker R, Pusey C (2004). "The changing profile of acute tubulointerstitial nephritis". Nephrol Dial Transplant 19 (1): 8-11. PMID 14671029.
- ↑ 2.0 2.1 Clarkson M, Giblin L, O'Connell F, O'Kelly P, Walshe J, Conlon P, O'Meara Y, Dormon A, Campbell E, Donohoe J (2004). "Acute interstitial nephritis: clinical features and response to corticosteroid therapy". Nephrol Dial Transplant 19 (11): 2778-83. PMID 15340098.
- ↑ 3.0 3.1 Rossert J (2001). "Drug-induced acute interstitial nephritis". Kidney Int 60 (2): 804-17. doi:10.1046/j.1523-1755.2001.060002804.x. PMID 11473672.
- ↑ Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J (1983). "Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy". Q J Med 52 (206): 194-211. PMID 6604293.
- ↑ Handa S (1986). "Drug-induced acute interstitial nephritis: report of 10 cases". CMAJ 135 (11): 1278-81. PMID 3779558.
- ↑ Buysen J, Houthoff H, Krediet R, Arisz L (1990). "Acute interstitial nephritis: a clinical and morphological study in 27 patients". Nephrol Dial Transplant 5 (2): 94-9. PMID 2113219.
- ↑ Schwarz A, Krause P, Kunzendorf U, Keller F, Distler A (2000). "The outcome of acute interstitial nephritis risk factors for the transition from acute to chronic interstitial nephritis". Clin Nephrol 54 (3): 179-90. PMID 11020015.
- ↑ Lins R, Verpooten G, De Clerck D, De Broe M (1986). "Urinary indices in acute interstitial nephritis". Clin Nephrol 26 (3): 131-3. PMID 3769228.
- ↑ Graham G, Lundy M, Moreno A (1983). "Failure of Gallium-67 scintigraphy to identify reliably noninfectious interstitial nephritis: concise communication". J Nucl Med 24 (7): 568-70. PMID 6864309.
- ↑ Linton A, Richmond J, Clark W, Lindsay R, Driedger A, Lamki L (1985). "Gallium67 scintigraphy in the diagnosis of acute renal disease". Clin Nephrol 24 (2): 84-7. PMID 3862487.
External links
WikiDoc Research Resources for Interstitial nephritis | |
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| Articles on Interstitial nephritis | Most recent articles on Interstitial nephritis • Most cited articles on Interstitial nephritis • Review articles on Interstitial nephritis • Articles on Interstitial nephritis in N Eng J Med, Lancet, BMJ |
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| Evidence Based Medicine Regarding Interstitial nephritis | Cochrane Collaboration on Interstitial nephritis • Bandolier on Interstitial nephritis • TRIP on Interstitial nephritis |
| Cost Effectiveness of Interstitial nephritis | Cost Effectiveness of Interstitial nephritis |
| Clinical Trials Involving Interstitial nephritis | Ongoing Trials on Interstitial nephritis at Clinical Trials.gov • Trial results on Interstitial nephritis • Clinical Trials on Interstitial nephritis at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Interstitial nephritis | US National Guidelines Clearinghouse on Interstitial nephritis • NICE Guidance on Interstitial nephritis • NHS PRODIGY Guidance • FDA on Interstitial nephritis • CDC on Interstitial nephritis |
| Textbook Information on Interstitial nephritis | Books and Textbook Information on Interstitial nephritis |
| Pharmacology Resources on Interstitial nephritis | Dosing of Interstitial nephritis • Drug interactions with Interstitial nephritis • Side effects of Interstitial nephritis • Allergic reactions to Interstitial nephritis • Overdose information on Interstitial nephritis • Carcinogenicity information on Interstitial nephritis • Interstitial nephritis in pregnancy • Pharmacokinetics of Interstitial nephritis • |
| Genetics, Pharmacogenomics, and Proteinomics of Interstitial nephritis | Genetics of Interstitial nephritis • Pharmacogenomics of Interstitial nephritis • Proteomics of Interstitial nephritis |
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| Healthcare Provider Resources on Interstitial nephritis | Symptoms of Interstitial nephritis • Causes & Risk Factors for Interstitial nephritis • Diagnostic studies for Interstitial nephritis • Treatment of Interstitial nephritis |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
