Combivir is the brand name for a pharmaceutical treatment for HIV infection. It is a fixed dose combination of two antiretroviral drugs, lamivudine (also called 3TC, with the brand name Epivir) and zidovudine (also called AZT, with the brand name Retrovir ). The combination of the two drugs has a stronger effect than either drug alone.
Both lamivudine and zidovudine are reverse transcriptase inhibitors, which block the action of an enzyme, reverse transcriptase, that the virus requires for reproduction. It reduces the viral load in the body and raises CD4 cell count.
It was approved by the FDA on September 26, 1997, making it the thirteenth approved antiretroviral. It is marketed by GlaxoSmithKline.
Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)
|Anti-herpesvirus (DNA, I)||guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine|
|HPV/MC (DNA, I)||Imiquimod • Podophyllotoxin|
|Hepatitis B (DNA, VII)||Adefovir • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir†|
|Hepatitis C (RNA, IV)||Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir†|
|Picornavirus (RNA, IV)||Pleconaril†|
|Anti-influenza agents (RNA, V)||Arbidol neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir†)|
|HIV (Reverse, VI)||See HIV pharm|
|Other antiviral agents||general (Inosine, Interferon)|
|†Undergoing clinical trials, not FDA approved.|
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