Fomivirsen
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| Image:Fomivirsen composite.png | |
| Fomivirsen
| |
| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | S01 |
| PubChem | ? |
| Chemical data | |
| Formula | C204H263N63O114P20S20 |
| Mol. mass | 6682.4 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B2 |
| Legal status | |
| Routes | Intravitreal injection |
Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS.
It is an oligonucleotide that blocks translation of viral mRNA by binding to a coding segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.
It is available as an intraocular injection in a concentration of 6.6 mg/ml1
References
1. Katzung, BG. Basic and Clinical Pharmacology 10th ed., 2007. McGraw-Hill Co., Inc.
See also
External links
- Diagram
- MedlinePlus DrugInfo uspdi-203675
- DDB 31313
- (2001) "Fomivirsen.". Drugs Today (Barc) 37 (4): 245-255. PMID 12768225.
- Geary R, Henry S, Grillone L (2002). "Fomivirsen: clinical pharmacology and potential drug interactions.". Clin Pharmacokinet 41 (4): 255-60. PMID 11978144.
- (2002) "Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS.". Am J Ophthalmol 133 (4): 475-83. PMID 11931781.
- Roehr B (1998). "Fomivirsen approved for CMV retinitis.". J Int Assoc Physicians AIDS Care 4 (10): 14-6. PMID 11365956.
Antivirals, other than for HIV (primarily J05, also S01AD and D06BB) | |
|---|---|
| Anti-herpesvirus (DNA, I) | guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine |
| HPV/MC (DNA, I) | Imiquimod • Podophyllotoxin |
| Hepatitis B (DNA, VII) | Adefovir • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir† |
| Hepatitis C (RNA, IV) | Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir† |
| Picornavirus (RNA, IV) | Pleconaril† |
| Anti-influenza agents (RNA, V) | Arbidol
adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir†) |
| HIV (Reverse, VI) | See HIV pharm |
| Other antiviral agents | general (Inosine, Interferon) |
| †Undergoing clinical trials, not FDA approved. | |
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