Histoplasmosis
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| Histoplasmosis Classification and external resources | |
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| Histoplasma capsulatum. Methenamine silver stain showing histopathologic changes in histoplasmosis. | |
| ICD-10 | B39. |
| ICD-9 | 115 |
| DiseasesDB | 5925 |
| MedlinePlus | 001082 |
| eMedicine | med/1021 ped/1017 |
| MeSH | D006660 |
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Histoplasmosis, also known as Darling's disease,[1] is a disease caused by the fungus Histoplasma capsulatum. Its symptoms vary greatly, but the disease primarily affects the lungs. Occasionally, other organs are affected—this form of the disease is called disseminated histoplasmosis, and it can be fatal if untreated.
Pathogen
H. capsulatum is found throughout the world and is endemic in certain areas of the United States, particularly in states bordering the Ohio River valley and the lower Mississippi River. (Positive histoplasmin skin tests occur in as many as 80% of the people living in areas where H. capsulatum is common, such as the eastern and central United States.) H. capsulatum grows in soil and material contaminated with bat or bird droppings. The fungus has been found in poultry house litter, caves, areas harboring bats, and in bird roosts (particularly those of starlings). The fungus is thermally dimorphic. In the environment it grows as a brownish mycelium, whereas at body temperature (37°C in humans) it morphs into a yeast. The inoculum is represented principally by microconidia that, once inhaled into the alveolar spaces, germinate and then transform into budding yeast cells.
Symptoms
If symptoms of histoplasmosis infection occur, they will start within 3 to 17 days after exposure; the average is 12-14 days. Most affected individuals have clinically-silent manifestations and show no apparent ill effects.[2]The acute phase of histoplasmosis is characterized by non-specific respiratory symptoms, often cough or flu-like. Chest X-ray findings are normal in 40-70% of cases.[2] Chronic histoplasmosis cases can resemble tuberculosis; disseminated histoplasmosis affects multiple organ systems and is fatal unless treated.
While histoplasmosis is the most common cause of fibrosing mediastinitis, this remains a relatively rare disease. Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. Lesions have a tendency to calcify as they heal.
Ocular histoplasmosis damages the retina of the eyes. Scar tissue is left on the retina which can experience leakage, resulting in a loss of vision not unlike macular degeneration.
Treatment
Antifungal medications are used to treat severe cases of acute histoplasmosis and all cases of chronic and disseminated disease. Typical treatment of severe disease first involves treatment with amphotericin B, followed by oral itraconazole.[3] In many milder cases, simply itraconazole is sufficient. Asymptomatic disease is typically not treated. Past infection results in partial protection against ill effects if reinfected.
Prevention
It is not practical to test or decontaminate most sites that may be contaminated with H. capsulatum, but the following precautions can be taken to reduce a person's risk of exposure:
- Avoid areas that may harbor the fungus, e.g., accumulations of bird or bat droppings.
- Before starting a job or activity having a risk for exposure to H. capsulatum, consult the NIOSH/NCID Document Histoplasmosis: Protecting Workers at Risk. This document contains information on work practices and personal protective equipment that will reduce the risk of infection.
Histoplasmosis in Popular Culture
- Johnny Cash included a reference to the disease, even correctly noting its source in bird droppings, in the song "Beans for Breakfast".[4]
- Bob Dylan was hospitalized due to histoplasmosis in 1997, causing the cancellation of concerts in the United Kingdom and Switzerland.[5]
- In the episode Family, episode 21 of season 3 of the television show 'House, M.D.' a patient was diagnosed with histoplasmosis.[6]
References
- ↑ Histoplasma capsulatum, cause of histoplasmosis in humans and other animals, Tom Volk's Fungus of the Month for January 2000.
- ↑ 2.0 2.1 Silberberg P. Radiology Teaching Files: Case 224856 (Histoplasmosis).
- ↑ Histoplasmosis: Fungal Infections: Merck Manual Home Edition.
- ↑ Beans for Breakfast lyrics
- ↑ CNN - Bob Dylan hospitalized with Histoplasmosis
- ↑ House episode "Family"
Note: The original version of this article is adapted from the U.S. CDC public domain document at http://www.cdc.gov/ncidod/dbmd/diseaseinfo/histoplasmosis_g.htm
External links
- Histoplasmosis Resource Guide from the National Eye Institute (NEI).
- NIOSH - Histoplasmosis - Protecting Workers at Risk
- Fibrosing Mediastinitis
Infectious diseases - Mycoses (B35-B49, 110-118) | |||||||||
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| Subcutaneous, systemic, and opportunistic |
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WikiDoc Research Resources for Histoplasmosis | |
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| Articles on Histoplasmosis | Most recent articles on Histoplasmosis • Most cited articles on Histoplasmosis • Review articles on Histoplasmosis • Articles on Histoplasmosis in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Histoplasmosis | Powerpoint slides on Histoplasmosis • Images of Histoplasmosis • Photos of Histoplasmosis • Podcasts & MP3s on Histoplasmosis • Videos on Histoplasmosis |
| Evidence Based Medicine Regarding Histoplasmosis | Cochrane Collaboration on Histoplasmosis • Bandolier on Histoplasmosis • TRIP on Histoplasmosis |
| Cost Effectiveness of Histoplasmosis | Cost Effectiveness of Histoplasmosis |
| Clinical Trials Involving Histoplasmosis | Ongoing Trials on Histoplasmosis at Clinical Trials.gov • Trial results on Histoplasmosis • Clinical Trials on Histoplasmosis at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Histoplasmosis | US National Guidelines Clearinghouse on Histoplasmosis • NICE Guidance on Histoplasmosis • NHS PRODIGY Guidance • FDA on Histoplasmosis • CDC on Histoplasmosis |
| Textbook Information on Histoplasmosis | Books and Textbook Information on Histoplasmosis |
| Pharmacology Resources on Histoplasmosis | Dosing of Histoplasmosis • Drug interactions with Histoplasmosis • Side effects of Histoplasmosis • Allergic reactions to Histoplasmosis • Overdose information on Histoplasmosis • Carcinogenicity information on Histoplasmosis • Histoplasmosis in pregnancy • Pharmacokinetics of Histoplasmosis • |
| Genetics, Pharmacogenomics, and Proteinomics of Histoplasmosis | Genetics of Histoplasmosis • Pharmacogenomics of Histoplasmosis • Proteomics of Histoplasmosis |
| Newstories on Histoplasmosis | Histoplasmosis in the news • Be alerted to news on Histoplasmosis • News trends on Histoplasmosis |
| Commentary on Histoplasmosis | Blogs on Histoplasmosis |
| Patient Resources on Histoplasmosis | Patient resources on Histoplasmosis • Discussion groups on Histoplasmosis • Patient Handouts on Histoplasmosis • Directions to Hospitals Treating Histoplasmosis • Risk calculators and risk factors for Histoplasmosis |
| Healthcare Provider Resources on Histoplasmosis | Symptoms of Histoplasmosis • Causes & Risk Factors for Histoplasmosis • Diagnostic studies for Histoplasmosis • Treatment of Histoplasmosis |
| Continuing Medical Education (CME) Programs on Histoplasmosis | CME Programs on Histoplasmosis |
| International Resources on Histoplasmosis | Histoplasmosis en Espanol • Histoplasmosis en Francais |
| Business Resources on Histoplasmosis | Histoplasmosis in the Marketplace • Patents on Histoplasmosis |
| Informatics Resources on Histoplasmosis | List of terms related to Histoplasmosis |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
