Adamantinoma

Adamantinoma
File:Adamantinoma - intermed mag.jpg
Micrograph of an adamantinoma showing the biphasic histomorphology. H&E stain..
ICD-O:	9310/0
DiseasesDB	31676
MeSH	D050398

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Adamantinoma is a rare bone cancer, making up less than 1% of all bone cancers. It predominantly arises in bone in a subcutaneous location (85% are in the tibia). Most commonly, patients are in their second or third decade, but it can occur over a wide age range.

Historical Perspective

The condition was first described by Fischer in 1913.

Pathophysiology

Histologically, islands of epithelial cells are found in a fibrous stroma.

Treatment

Treatment consists of wide resection or amputation. Metastases are rare at presentation but may occur in up to 30% of patients during the disease course. Prognosis is excellent, with overall survival of 85% at 10 years, but is lower when wide surgical margins cannot be obtained.

References

• (2003) Campbell's Operative Orthopedics, 10th edition. 

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