Whipworm infection pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2], Syed Hassan A. Kazmi BSc, MD [3]

Overview

Infection is acquired by the ingestion of embryonated eggs from contaminated drinking water and food. Once the eggs are ingested, they hatch in the small intestine then, larvae enter the intestinal crypts. The larvae migrate to the proximal colon and mature into adult worms. The females begin to oviposit 60 to 70 days after infection and shed between 3,000 and 20,000 eggs per day. Whipworm causes disease by colonic mucosal invasion by the adult worms and resulting in inflammation of the colonic mucosa.

Pathophysiology

Life Cycle

Life Cycle of Trichiuris trichiura

1. The eggs develop into a 2-cell stage.

2. The two cell stage then leads to an advanced cleavage stage.

3. The eggs embryonate.

4. Eggs become infective in 15 to 30 days.

5. Mature adult worms travel in the colon.

6. The adult worms (approximately 4 cm in length) live in the cecum and ascending colon. The life span of the adult worm is approximately 1 year.

Transmission

  • Whipworm infection is acquired by the ingestion of embryonated eggs from contaminated drinking water and food.

Pathogenesis

Host response

Associated Conditions

Gross Pathology

Rectal prolapse in whipworm infection

Microscopic Pathology

Colonic Biopsy

Black arrows showing worm embeded in mucosa of colon and white arrow showing one end of worm in lumen

Stool Examination

  • A stool examination for ova and parasites reveals the presence of whipworm eggs.
  • The diagnostic characteristics are:[10]
    • A typical barrel shape
    • Two polar plugs, that are unstained
    • Size: 50 to 54 µm by 22 to 23 µm
    • The external layer of the shell of the egg is yellow-brown (in contrast to the clear polar plugs).
T.trichiura egg


References

  1. Elston DM (2006). "What's eating you? Trichuris trichiura (human whipworm)". Cutis. 77 (2): 75–6. PMID 16570666.
  2. Elsayed S, Yilmaz A, Hershfield N (2004). "Trichuris trichiura worm infection". Gastrointest Endosc. 60 (6): 990–1. PMID 15605023.
  3. Tilney LG, Connelly PS, Guild GM, Vranich KA, Artis D (2005). "Adaptation of a nematode parasite to living within the mammalian epithelium". J Exp Zool A Comp Exp Biol. 303 (11): 927–45. doi:10.1002/jez.a.214. PMID 16217807.
  4. "Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm - ScienceDirect".
  5. Maizels RM, Bundy DA, Selkirk ME, Smith DF, Anderson RM (1993). "Immunological modulation and evasion by helminth parasites in human populations". Nature. 365 (6449): 797–805. doi:10.1038/365797a0. PMID 8413664.
  6. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ (2006). "Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm". Lancet. 367 (9521): 1521–32. doi:10.1016/S0140-6736(06)68653-4. PMID 16679166.
  7. "CDC - Trichuriasis".
  8. Kaur G, Raj SM, Naing NN (2002). "Trichuriasis: localized inflammatory responses in the colon". Southeast Asian J Trop Med Public Health. 33 (2): 224–8. PMID 12236416.
  9. Ok KS, Kim YS, Song JH, Lee JH, Ryu SH, Lee JH, Moon JS, Whang DH, Lee HK (2009). "Trichuris trichiura infection diagnosed by colonoscopy: case reports and review of literature". Korean J. Parasitol. 47 (3): 275–80. doi:10.3347/kjp.2009.47.3.275. PMC 2735694. PMID 19724702.
  10. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ (2006). "Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm". Lancet. 367 (9521): 1521–32. doi:10.1016/S0140-6736(06)68653-4. PMID 16679166.

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