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{{Infobox_gene}}
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'''Mitochondrial uncoupling protein 2''' is a [[protein]] that in humans is encoded by the ''UCP2'' [[gene]].<ref name="pmid9196039">{{cite journal | vauthors = Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB | title = UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue | journal = Biochem Biophys Res Commun | volume = 235 | issue = 1 | pages = 79–82 |date=Jul 1997 | pmid = 9196039 | pmc =  | doi = 10.1006/bbrc.1997.6740 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Uncoupling protein 2 (mitochondrial, proton carrier)
| HGNCid = 12518
| Symbol = UCP2
| AltSymbols =; SLC25A8; UCPH
| OMIM = 601693
| ECnumber =
| Homologene = 2516
| MGIid = 109354
  | GeneAtlas_image1 = PBB_GE_UCP2_208998_at_tn.png
| GeneAtlas_image2 = PBB_GE_UCP2_208997_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006839 |text = mitochondrial transport}} {{GNF_GO|id=GO:0015992 |text = proton transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7351
    | Hs_Ensembl = ENSG00000175567
    | Hs_RefseqProtein = NP_003346
    | Hs_RefseqmRNA = NM_003355
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 73363360
    | Hs_GenLoc_end = 73372000
    | Hs_Uniprot = P55851
    | Mm_EntrezGene = 22228
    | Mm_Ensembl = ENSMUSG00000033685
    | Mm_RefseqmRNA = NM_011671
    | Mm_RefseqProtein = NP_035801
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 100367440
    | Mm_GenLoc_end = 100376255
    | Mm_Uniprot = Q549J5
  }}
}}
'''Uncoupling protein 2 (mitochondrial, proton carrier)''', also known as '''UCP2''', is a human [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.<ref>{{cite web | title = Entrez Gene: UCP2 uncoupling protein 2 (mitochondrial, proton carrier)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7351| accessdate = }}</ref>
| summary_text = Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. Although it was originally thought to play a role in nonshivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.<ref name="pmid11101840">{{cite journal  |vauthors=Arsenijevic D, Onuma H, Pecqueur C, etal |title=Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production |journal=Nat. Genet. |volume=26 |issue=4 |pages=435–9 |date=December 2000 |pmid=11101840 |doi=10.1038/82565 |url=}}</ref> Chromosomal order is 5'-UCP3-UCP2-3'.<ref>{{cite web | title = Entrez Gene: UCP2 uncoupling protein 2 (mitochondrial, proton carrier)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7351| accessdate = }}</ref>
}}
}}
[[File:MMDB_ID_92271_PDB_ID_2LCK_Mitochondrial_Uncoupling_Protein_2.png|thumb|286px|Mitochondrial Uncoupling Protein 2]]
==See also==
* [[Uncoupling protein]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 Pt 2 |issue=  |pages= 161-79 |year= 2000 |pmid= 10620491 |doi=  }}
*{{cite journal  | vauthors=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 |issue=  2|pages= 161–79 |year= 2000 |pmid= 10620491 |doi=10.1042/0264-6021:3450161  | pmc=1220743 }}
*{{cite journal  | author=Saleh MC, Wheeler MB, Chan CB |title=Uncoupling protein-2: evidence for its function as a metabolic regulator. |journal=Diabetologia |volume=45 |issue= 2 |pages= 174-87 |year= 2002 |pmid= 11935148 |doi= 10.1007/s00125-001-0737-x }}
*{{cite journal  | vauthors=Saleh MC, Wheeler MB, Chan CB |title=Uncoupling protein-2: evidence for its function as a metabolic regulator. |journal=Diabetologia |volume=45 |issue= 2 |pages= 174–87 |year= 2002 |pmid= 11935148 |doi= 10.1007/s00125-001-0737-x }}
*{{cite journal  | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. (Paris) |volume=63 |issue= 2 Pt 1 |pages= 106-10 |year= 2002 |pmid= 11994670 |doi=  }}
*{{cite journal  | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. |volume=63 |issue= 2 Pt 1 |pages= 106–10 |year= 2002 |pmid= 11994670 |doi=  }}
*{{cite journal  | author=Horvath TL, Diano S, Barnstable C |title=Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. |journal=Biochem. Pharmacol. |volume=65 |issue= 12 |pages= 1917-21 |year= 2003 |pmid= 12787871 |doi=  }}
*{{cite journal  | vauthors=Horvath TL, Diano S, Barnstable C |title=Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. |journal=Biochem. Pharmacol. |volume=65 |issue= 12 |pages= 1917–21 |year= 2003 |pmid= 12787871 |doi=10.1016/S0006-2952(03)00143-6 }}
*{{cite journal | author=Paradis E, Clavel S, Bouillaud F, ''et al.'' |title=Uncoupling protein 2: a novel player in neuroprotection. |journal=Trends in molecular medicine |volume=9 |issue= 12 |pages= 522-5 |year= 2004 |pmid= 14659466 |doi=  }}
*{{cite journal   |vauthors=Paradis E, Clavel S, Bouillaud F, etal |title=Uncoupling protein 2: a novel player in neuroprotection. |journal=Trends in Molecular Medicine |volume=9 |issue= 12 |pages= 522–5 |year= 2004 |pmid= 14659466 |doi=10.1016/j.molmed.2003.10.009 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Fleury C, Neverova M, Collins S, ''et al.'' |title=Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 269-72 |year= 1997 |pmid= 9054939 |doi= 10.1038/ng0397-269 }}
*{{cite journal   |vauthors=Fleury C, Neverova M, Collins S, etal |title=Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 269–72 |year= 1997 |pmid= 9054939 |doi= 10.1038/ng0397-269 }}
*{{cite journal | author=Gimeno RE, Dembski M, Weng X, ''et al.'' |title=Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. |journal=Diabetes |volume=46 |issue= 5 |pages= 900-6 |year= 1997 |pmid= 9133562 |doi=  }}
*{{cite journal   |vauthors=Gimeno RE, Dembski M, Weng X, etal |title=Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. |journal=Diabetes |volume=46 |issue= 5 |pages= 900–6 |year= 1997 |pmid= 9133562 |doi=10.2337/diabetes.46.5.900 }}
*{{cite journal | author=Boss O, Samec S, Paoloni-Giacobino A, ''et al.'' |title=Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. |journal=FEBS Lett. |volume=408 |issue= 1 |pages= 39-42 |year= 1997 |pmid= 9180264 |doi=  }}
*{{cite journal   |vauthors=Boss O, Samec S, Paoloni-Giacobino A, etal |title=Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. |journal=FEBS Lett. |volume=408 |issue= 1 |pages= 39–42 |year= 1997 |pmid= 9180264 |doi=10.1016/S0014-5793(97)00384-0  }}
*{{cite journal  | author=Vidal-Puig A, Solanes G, Grujic D, ''et al.'' |title=UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 79-82 |year= 1997 |pmid= 9196039 |doi= 10.1006/bbrc.1997.6740 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Hodný Z, Kolárová P, Rossmeisl M, etal |title=High expression of uncoupling protein 2 in foetal liver. |journal=FEBS Lett. |volume=425 |issue= 2 |pages= 185–90 |year= 1998 |pmid= 9559644 |doi=10.1016/S0014-5793(98)00230-0 }}
*{{cite journal | author=Hodný Z, Kolárová P, Rossmeisl M, ''et al.'' |title=High expression of uncoupling protein 2 in foetal liver. |journal=FEBS Lett. |volume=425 |issue= 2 |pages= 185-90 |year= 1998 |pmid= 9559644 |doi=  }}
*{{cite journal   |vauthors=Argyropoulos G, Brown AM, Peterson R, etal |title=Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects. |journal=Diabetes |volume=47 |issue= 4 |pages= 685–7 |year= 1998 |pmid= 9568704 |doi=10.2337/diabetes.47.4.685 }}
*{{cite journal | author=Argyropoulos G, Brown AM, Peterson R, ''et al.'' |title=Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects. |journal=Diabetes |volume=47 |issue= 4 |pages= 685-7 |year= 1998 |pmid= 9568704 |doi=  }}
*{{cite journal   |vauthors=Tu N, Chen H, Winnikes U, etal |title=Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene. |journal=Life Sci. |volume=64 |issue= 3 |pages= PL41–50 |year= 1999 |pmid= 10027754 |doi=10.1016/S0024-3205(98)00555-4 }}
*{{cite journal | author=Tu N, Chen H, Winnikes U, ''et al.'' |title=Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene. |journal=Life Sci. |volume=64 |issue= 3 |pages= PL41-50 |year= 1999 |pmid= 10027754 |doi=  }}
*{{cite journal   |vauthors=Pecqueur C, Cassard-Doulcier AM, Raimbault S, etal |title=Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 1 |pages= 40–6 |year= 1999 |pmid= 10082652 |doi= 10.1006/bbrc.1998.0146 }}
*{{cite journal | author=Pecqueur C, Cassard-Doulcier AM, Raimbault S, ''et al.'' |title=Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 1 |pages= 40-6 |year= 1999 |pmid= 10082652 |doi= 10.1006/bbrc.1998.0146 }}
*{{cite journal  | vauthors=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63–70 |year= 2000 |pmid= 10772343 |doi=10.1080/713803586 }}
*{{cite journal  | author=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63-70 |year= 2000 |pmid= 10772343 |doi=  }}
*{{cite journal   |vauthors=Pierrat B, Ito M, Hinz W, etal |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680–7 |year= 2000 |pmid= 10785390 |doi=10.1046/j.1432-1327.2000.01285.x }}
*{{cite journal | author=Pierrat B, Ito M, Hinz W, ''et al.'' |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680-7 |year= 2000 |pmid= 10785390 |doi=  }}
*{{cite journal   |vauthors=Esterbauer H, Schneitler C, Oberkofler H, etal |title=A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 178–83 |year= 2001 |pmid= 11381268 |doi= 10.1038/88911 }}
*{{cite journal | author=Esterbauer H, Schneitler C, Oberkofler H, ''et al.'' |title=A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 178-83 |year= 2001 |pmid= 11381268 |doi= 10.1038/88911 }}
*{{cite journal   |vauthors=Echtay KS, Roussel D, St-Pierre J, etal |title=Superoxide activates mitochondrial uncoupling proteins. |journal=Nature |volume=415 |issue= 6867 |pages= 96–9 |year= 2002 |pmid= 11780125 |doi= 10.1038/415096a }}
*{{cite journal | author=Echtay KS, Roussel D, St-Pierre J, ''et al.'' |title=Superoxide activates mitochondrial uncoupling proteins. |journal=Nature |volume=415 |issue= 6867 |pages= 96-9 |year= 2002 |pmid= 11780125 |doi= 10.1038/415096a }}
}}
}}
*{{cite journal|last=|first=|vauthors=Rupprecht A, Sittner D, Smorodchenko A, Hilse KE, Goyn J, Moldzio R, Seiler AE, Bräuer AU, Pohl EE|title=Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function|journal=PLoS One|volume=9|issue=2|pages=e88474|year=2014|doi=10.1371/journal.pone.0088474|pmid=24523901|pmc=3921169}}
*{{cite journal|last=|first=|vauthors=Rupprecht A, Bräuer AU, Smorodchenko A, Goyn J, Hilse KE, Shabalina IG, Infante-Duarte C, Pohl EE|title=Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation|journal=PLoS One|volume=7|issue=8|pages=e41406|year=2012|doi=10.1371/journal.pone.0041406|pmid=22870219|pmc=3411681}}


[[ca:UCP2]]
{{refend}}


{{refend}}
<ref>{{Cite journal|last=Rupprecht|first=Anne|last2=Sittner|first2=Dana|last3=Smorodchenko|first3=Alina|last4=Hilse|first4=Karolina E.|last5=Goyn|first5=Justus|last6=Moldzio|first6=Rudolf|last7=Seiler|first7=Andrea E. M.|last8=Bräuer|first8=Anja U.|last9=Pohl|first9=Elena E.|date=2014-02-11|title=Uncoupling Protein 2 and 4 Expression Pattern during Stem Cell Differentiation Provides New Insight into Their Putative Function|journal=PLoS ONE|language=en|volume=9|issue=2|pages=e88474|doi=10.1371/journal.pone.0088474|issn=1932-6203|pmc=3921169|pmid=24523901}}</ref>{{NLM content}}


{{NLM content}}
{{membrane-protein-stub}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Transmembrane proteins]]


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[[Category:Solute carrier family]]


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{{membrane-protein-stub}}

Latest revision as of 19:02, 11 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

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View/Edit Human

Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.[1]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. Although it was originally thought to play a role in nonshivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.[2] Chromosomal order is 5'-UCP3-UCP2-3'.[3]

File:MMDB ID 92271 PDB ID 2LCK Mitochondrial Uncoupling Protein 2.png
Mitochondrial Uncoupling Protein 2

See also

References

  1. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.
  2. Arsenijevic D, Onuma H, Pecqueur C, et al. (December 2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nat. Genet. 26 (4): 435–9. doi:10.1038/82565. PMID 11101840.
  3. "Entrez Gene: UCP2 uncoupling protein 2 (mitochondrial, proton carrier)".

Further reading

[1]This article incorporates text from the United States National Library of Medicine, which is in the public domain.



  1. Rupprecht, Anne; Sittner, Dana; Smorodchenko, Alina; Hilse, Karolina E.; Goyn, Justus; Moldzio, Rudolf; Seiler, Andrea E. M.; Bräuer, Anja U.; Pohl, Elena E. (2014-02-11). "Uncoupling Protein 2 and 4 Expression Pattern during Stem Cell Differentiation Provides New Insight into Their Putative Function". PLoS ONE. 9 (2): e88474. doi:10.1371/journal.pone.0088474. ISSN 1932-6203. PMC 3921169. PMID 24523901.