SLCO1B1
| Solute carrier organic anion transporter family, member 1B1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SLCO1B1 ; LST-1; MGC133282; OATP-C; OATP1B1; OATP2; SLC21A6 | ||||||||||
| External IDs | Template:OMIM5 HomoloGene: 74575 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Solute carrier organic anion transporter family, member 1B1, also known as SLCO1B1, is a human gene.[1]
See also
References
Further reading
- Abe T, Kakyo M, Tokui T; et al. (1999). "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J. Biol. Chem. 274 (24): 17159–63. PMID 10358072.
- Hsiang B, Zhu Y, Wang Z; et al. (2000). "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters". J. Biol. Chem. 274 (52): 37161–8. PMID 10601278.
- König J, Cui Y, Nies AT, Keppler D (2000). "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G156–64. PMID 10644574.
- Rollinger-Holzinger I, Eibl B, Pauly M; et al. (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. PMID 10706707.
- König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
- Tamai I, Nezu J, Uchino H; et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
- Cui Y, König J, Leier I; et al. (2001). "Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6". J. Biol. Chem. 276 (13): 9626–30. doi:10.1074/jbc.M004968200. PMID 11134001.
- Tirona RG, Leake BF, Merino G, Kim RB (2001). "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans". J. Biol. Chem. 276 (38): 35669–75. doi:10.1074/jbc.M103792200. PMID 11477075.
- Jung D, Hagenbuch B, Gresh L; et al. (2001). "Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha". J. Biol. Chem. 276 (40): 37206–14. doi:10.1074/jbc.M103988200. PMID 11483603.
- Nozawa T, Nakajima M, Tamai I; et al. (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. PMID 12130747.
- Michalski C, Cui Y, Nies AT; et al. (2003). "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter". J. Biol. Chem. 277 (45): 43058–63. doi:10.1074/jbc.M207735200. PMID 12196548.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003). "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation". J. Pharmacol. Exp. Ther. 304 (1): 223–8. doi:10.1124/jpet.102.043026. PMID 12490595.
- Wang P, Kim RB, Chowdhury JR, Wolkoff AW (2003). "The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695–9. doi:10.1074/jbc.M301100200. PMID 12670950.
- Nishizato Y, Ieiri I, Suzuki H; et al. (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365.
- Niemi M, Schaeffeler E, Lang T; et al. (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics. 14 (7): 429–40. PMID 15226675.
- Huang MJ, Kua KE, Teng HC; et al. (2005). "Risk factors for severe hyperbilirubinemia in neonates". Pediatr. Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464.
- Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia". Chem. Biol. Interact. 150 (2): 179–87. doi:10.1016/j.cbi.2004.08.008. PMID 15535988.
- Huang CS, Huang MJ, Lin MS; et al. (2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenet. Genomics. 15 (1): 43–50. PMID 15864125.
- Katz DA, Carr R, Grimm DR; et al. (2006). "Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics". Clin. Pharmacol. Ther. 79 (3): 186–96. doi:10.1016/j.clpt.2005.11.003. PMID 16513443.
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