SLC5A1
| Solute carrier family 5 (sodium/glucose cotransporter), member 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SLC5A1 ; D22S675; NAGT; SGLT1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55456 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC5A1 206628 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Solute carrier family 5 (sodium/glucose cotransporter), member 1, also known as SLC5A1, is a human gene.[1]
Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated-diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.[supplied by OMIM][1]
See also
References
Further reading
- Wright EM, Loo DD, Panayotova-Heiermann M; et al. (1995). "'Active' sugar transport in eukaryotes". J. Exp. Biol. 196: 197–212. PMID 7823022.
- Wright EM, Turk E, Martin MG (2003). "Molecular basis for glucose-galactose malabsorption". Cell Biochem. Biophys. 36 (2–3): 115–21. PMID 12139397.
- Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell Proteomics. 1 (11): 845–67. PMID 12488461.
- Turk E, Zabel B, Mundlos S; et al. (1991). "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter". Nature. 350 (6316): 354–6. doi:10.1038/350354a0. PMID 2008213.
- Hediger MA, Turk E, Wright EM (1989). "Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5748–52. PMID 2490366.
- Delézay O, Baghdiguian S, Fantini J (1995). "The development of Na(+)-dependent glucose transport during differentiation of an intestinal epithelial cell clone is regulated by protein kinase C.". J. Biol. Chem. 270 (21): 12536–41. PMID 7759499.
- Turk E, Martín MG, Wright EM (1994). "Structure of the human Na+/glucose cotransporter gene SGLT1". J. Biol. Chem. 269 (21): 15204–9. PMID 8195156.
- Turk E, Klisak I, Bacallao R; et al. (1993). "Assignment of the human Na+/glucose cotransporter gene SGLT1 to chromosome 22q13.1". Genomics. 17 (3): 752–4. doi:10.1006/geno.1993.1399. PMID 8244393.
- Martín MG, Turk E, Lostao MP; et al. (1996). "Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption". Nat. Genet. 12 (2): 216–20. doi:10.1038/ng0296-216. PMID 8563765.
- Turk E, Kerner CJ, Lostao MP, Wright EM (1996). "Membrane topology of the human Na+/glucose cotransporter SGLT1". J. Biol. Chem. 271 (4): 1925–34. PMID 8567640.
- Lam JT, Martín MG, Turk E; et al. (1999). "Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects". Biochim. Biophys. Acta. 1453 (2): 297–303. PMID 10036327.
- Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Obermeier S, Hüselweh B, Tinel H; et al. (2001). "Expression of glucose transporters in lactating human mammary gland epithelial cells". European journal of nutrition. 39 (5): 194–200. PMID 11131365.
- Kasahara M, Maeda M, Hayashi S; et al. (2001). "A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein". Biochim. Biophys. Acta. 1536 (2–3): 141–7. PMID 11406349.
- Roll P, Massacrier A, Pereira S; et al. (2002). "New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families". Gene. 285 (1–2): 141–8. PMID 12039040.
- Ikari A, Nakano M, Kawano K, Suketa Y (2002). "Up-regulation of sodium-dependent glucose transporter by interaction with heat shock protein 70". J. Biol. Chem. 277 (36): 33338–43. doi:10.1074/jbc.M200310200. PMID 12082088.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.