SLC3A2

Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
File:PBB Protein SLC3A2 image.jpg PDB rendering based on 2dh2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dh2​, 2dh3​
Identifiers
Symbols	SLC3A2 ; 4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1; NACAE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1795
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC3A2 200924 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2, also known as SLC3A2, is a human gene.

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Rochelle JM, Watson ML, Oakey RJ, Seldin MF (1992). "A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus". Genomics. 14 (1): 26–31. PMID 1358795.CS1 maint: Multiple names: authors list (link)
• Michalak M, Quackenbush EJ, Letarte M (1986). "Inhibition of Na+/Ca2+ exchanger activity in cardiac and skeletal muscle sarcolemmal vesicles by monoclonal antibody 44D7". J. Biol. Chem. 261 (1): 92–5. PMID 2416754.CS1 maint: Multiple names: authors list (link)
• Teixeira S, Di Grandi S, Kühn LC (1987). "Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus". J. Biol. Chem. 262 (20): 9574–80. PMID 3036867.CS1 maint: Multiple names: authors list (link)
• Gottesdiener KM, Karpinski BA, Lindsten T; et al. (1989). "Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation". Mol. Cell. Biol. 8 (9): 3809–19. PMID 3265470.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lindsten T, June CH, Thompson CB, Leiden JM (1989). "Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms". Mol. Cell. Biol. 8 (9): 3820–6. PMID 3265471.CS1 maint: Multiple names: authors list (link)
• Quackenbush E, Clabby M, Gottesdiener KM; et al. (1987). "Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth". Proc. Natl. Acad. Sci. U.S.A. 84 (18): 6526–30. PMID 3476959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lumadue JA, Glick AB, Ruddle FH (1988). "Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9204–8. PMID 3480538.CS1 maint: Multiple names: authors list (link)
• Posillico JT, Srikanta S, Eisenbarth G; et al. (1987). "Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion". J. Clin. Endocrinol. Metab. 64 (1): 43–50. PMID 3782435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hemler ME, Strominger JL (1982). "Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines". J. Immunol. 129 (2): 623–8. PMID 6177771.
• Peters PG, Kamarck ME, Hemler ME; et al. (1983). "Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen". Somatic Cell Genet. 8 (6): 825–34. PMID 6187076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Francke U, Foellmer BE, Haynes BF (1983). "Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11". Somatic Cell Genet. 9 (3): 333–44. PMID 6190235.CS1 maint: Multiple names: authors list (link)
• Haynes BF, Hemler ME, Mann DL; et al. (1981). "Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes". J. Immunol. 126 (4): 1409–14. PMID 7204970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohgimoto S, Tabata N, Suga S; et al. (1995). "Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules". J. Immunol. 155 (7): 3585–92. PMID 7561057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohgimoto S, Tabata N, Suga S; et al. (1996). "Regulation of human immunodeficiency virus gp160-mediated cell fusion by antibodies against fusion regulatory protein 1". J. Gen. Virol. 77 ( Pt 11): 2747–56. PMID 8922468.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Courseaux A, Grosgeorge J, Gaudray P; et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics. 37 (3): 354–65. PMID 8938448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tabata N, Ido M, Suga S; et al. (1998). "Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160". Med. Microbiol. Immunol. 186 (2–3): 115–23. PMID 9403839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.