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{{Infobox_gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''4F2 cell-surface antigen heavy chain'''  is a [[protein]] that in humans is encoded by the ''SLC3A2'' (solute carrier family 3 member 2) [[gene]].<ref name="pmid3036867">{{cite journal | vauthors = Teixeira S, Di Grandi S, Kühn LC | title = Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus | journal = J Biol Chem | volume = 262 | issue = 20 | pages = 9574–80 | date = Aug 1987 | pmid = 3036867 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6520| accessdate = }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_SLC3A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dh2.
| PDB = {{PDB2|2dh2}}, {{PDB2|2dh3}}
| Name = Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
| HGNCid = 11026
| Symbol = SLC3A2
| AltSymbols =; 4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1; NACAE
| OMIM = 158070
| ECnumber = 
| Homologene = 1795
| MGIid = 96955
| GeneAtlas_image1 = PBB_GE_SLC3A2_200924_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0005432 |text = calcium:sodium antiporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015171 |text = amino acid transmembrane transporter activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006865 |text = amino acid transport}} {{GNF_GO|id=GO:0015827 |text = tryptophan transport}} {{GNF_GO|id=GO:0016049 |text = cell growth}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6520
    | Hs_Ensembl = ENSG00000168003
    | Hs_RefseqProtein = NP_001012679
    | Hs_RefseqmRNA = NM_001012661
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 62380094
    | Hs_GenLoc_end = 62412928
    | Hs_Uniprot = P08195
    | Mm_EntrezGene = 17254
    | Mm_Ensembl = ENSMUSG00000010095
    | Mm_RefseqmRNA = NM_008577
    | Mm_RefseqProtein = NP_032603
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 8773927
    | Mm_GenLoc_end = 8780921
    | Mm_Uniprot = Q3TIP1
  }}
}}
'''Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2''', also known as '''SLC3A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6520| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SLC3A2 comprises the heavy subunit of the '''large neutral amino acid transporter''' ('''LAT1''') that is also known as [[CD98]] (cluster of differentiation 98).<ref name="pmid15880135">{{cite journal | vauthors = Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D | title = Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation | journal = Lab. Invest. | volume = 85 | issue = 7 | pages = 932–41 | year = 2005 | pmid = 15880135 | doi = 10.1038/labinvest.3700289 }}</ref><ref name="pmid16097038">{{cite journal | vauthors = Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G | title = CD98, a novel marker of transient amplifying human keratinocytes | journal = Proteomics | volume = 5 | issue = 14 | pages = 3637–45 | year = 2005 | pmid = 16097038 | doi = 10.1002/pmic.200401224 }}</ref>
{{PBB_Summary
 
| section_title =  
== Function ==
| summary_text = This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6520| accessdate = }}</ref>
 
}}
SLC3A2 is a member of the [[solute carrier family]] and encodes a cell surface, transmembrane protein with an [[alpha-amylase]] domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
==References==
 
{{reflist|2}}
LAT1 is a heterodimeric [[membrane transport protein]] that preferentially transports neutral branched ([[valine]], [[leucine]], [[isoleucine]]) and aromatic ([[tryptophan]], [[tyrosine]]) [[amino acid]]s.<ref name="pmid10518579">{{cite journal | vauthors = Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM | title = Selective expression of the large neutral amino acid transporter at the blood–brain barrier | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 21 | pages = 12079–84 | year = 1999 | pmid = 10518579 | pmc = 18415 | doi = 10.1073/pnas.96.21.12079 }}</ref> LAT is highly expressed in brain [[capillaries]] (which form the [[blood brain barrier]]) relative to other tissues.<ref name="pmid10518579" />
==Further reading==
 
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:
* 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)<ref name="Palacin_2004">{{cite journal | vauthors = Palacín M, Kanai Y | title = The ancillary proteins of HATs: SLC3 family of amino acid transporters | journal = Pflugers Arch | volume = 447 | issue = 5 | pages = 490–494 | year = 2004 | pmid = 14770309 | doi = 10.1007/s00424-003-1062-7 }}</ref>
* CD98 light subunit protein encoded by the [[SLC7A5]] gene<ref name="Verrey_2004">{{cite journal | vauthors = Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y | title = CATs and HATs: the SLC7 family of amino acid transporters | journal = Pflugers Arch | volume = 447 | issue = 5 | pages = 532–542 | year = 2004 | pmid = 14770310 | doi = 10.1007/s00424-003-1086-z }}</ref>
 
== Interactions ==
 
SLC3A2 has been shown to [[Protein-protein interaction|interact]] with [[SLC7A7]].<ref name=pmid9878049>{{cite journal | vauthors = Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F | title = Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family | journal = EMBO J. | volume = 18 | issue = 1 | pages = 49–57 | date = Jan 1999 | pmid = 9878049 | pmc = 1171101 | doi = 10.1093/emboj/18.1.49 }}</ref>
 
== See also ==
* [[Heterodimeric amino acid transporter]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rochelle JM, Watson ML, Oakey RJ, Seldin MF | title = A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus | journal = Genomics | volume = 14 | issue = 1 | pages = 26–31 | year = 1992 | pmid = 1358795 | doi = 10.1016/S0888-7543(05)80278-2 }}
| citations =
* {{cite journal | vauthors = Michalak M, Quackenbush EJ, Letarte M | title = Inhibition of Na+/Ca2+ exchanger activity in cardiac and skeletal muscle sarcolemmal vesicles by monoclonal antibody 44D7 | journal = J. Biol. Chem. | volume = 261 | issue = 1 | pages = 92–5 | year = 1986 | pmid = 2416754 | doi =  }}
*{{cite journal | author=Rochelle JM, Watson ML, Oakey RJ, Seldin MF |title=A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. |journal=Genomics |volume=14 |issue= 1 |pages= 26-31 |year= 1992 |pmid= 1358795 |doi= }}
* {{cite journal | vauthors = Gottesdiener KM, Karpinski BA, Lindsten T, Strominger JL, Jones NH, Thompson CB, Leiden JM | title = Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation | journal = Mol. Cell. Biol. | volume = 8 | issue = 9 | pages = 3809–19 | year = 1989 | pmid = 3265470 | pmc = 365439 | doi =  }}
*{{cite journal | author=Michalak M, Quackenbush EJ, Letarte M |title=Inhibition of Na+/Ca2+ exchanger activity in cardiac and skeletal muscle sarcolemmal vesicles by monoclonal antibody 44D7. |journal=J. Biol. Chem. |volume=261 |issue= 1 |pages= 92-5 |year= 1986 |pmid= 2416754 |doi=  }}
* {{cite journal | vauthors = Lindsten T, June CH, Thompson CB, Leiden JM | title = Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms | journal = Mol. Cell. Biol. | volume = 8 | issue = 9 | pages = 3820–6 | year = 1989 | pmid = 3265471 | pmc = 365440 | doi =  }}
*{{cite journal | author=Teixeira S, Di Grandi S, Kühn LC |title=Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus. |journal=J. Biol. Chem. |volume=262 |issue= 20 |pages= 9574-80 |year= 1987 |pmid= 3036867 |doi=  }}
* {{cite journal | vauthors = Quackenbush E, Clabby M, Gottesdiener KM, Barbosa J, Jones NH, Strominger JL, Speck S, Leiden JM | title = Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 18 | pages = 6526–30 | year = 1987 | pmid = 3476959 | pmc = 299110 | doi = 10.1073/pnas.84.18.6526 }}
*{{cite journal | author=Gottesdiener KM, Karpinski BA, Lindsten T, ''et al.'' |title=Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. |journal=Mol. Cell. Biol. |volume=8 |issue= 9 |pages= 3809-19 |year= 1989 |pmid= 3265470 |doi=  }}
* {{cite journal | vauthors = Lumadue JA, Glick AB, Ruddle FH | title = Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 24 | pages = 9204–8 | year = 1988 | pmid = 3480538 | pmc = 299721 | doi = 10.1073/pnas.84.24.9204 }}
*{{cite journal | author=Lindsten T, June CH, Thompson CB, Leiden JM |title=Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms. |journal=Mol. Cell. Biol. |volume=8 |issue= 9 |pages= 3820-6 |year= 1989 |pmid= 3265471 |doi= }}
* {{cite journal | vauthors = Posillico JT, Srikanta S, Eisenbarth G, Quaranta V, Kajiji S, Brown EM | title = Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion | journal = J. Clin. Endocrinol. Metab. | volume = 64 | issue = 1 | pages = 43–50 | year = 1987 | pmid = 3782435 | doi = 10.1210/jcem-64-1-43 }}
*{{cite journal | author=Quackenbush E, Clabby M, Gottesdiener KM, ''et al.'' |title=Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 18 |pages= 6526-30 |year= 1987 |pmid= 3476959 |doi= }}
* {{cite journal | vauthors = Hemler ME, Strominger JL | title = Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines | journal = J. Immunol. | volume = 129 | issue = 2 | pages = 623–8 | year = 1982 | pmid = 6177771 | doi =  }}
*{{cite journal | author=Lumadue JA, Glick AB, Ruddle FH |title=Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 24 |pages= 9204-8 |year= 1988 |pmid= 3480538 |doi= }}
* {{cite journal | vauthors = Peters PG, Kamarck ME, Hemler ME, Strominger JL, Ruddle FH | title = Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen | journal = Somatic Cell Genet. | volume = 8 | issue = 6 | pages = 825–34 | year = 1983 | pmid = 6187076 | doi = 10.1007/BF01543022 }}
*{{cite journal | author=Posillico JT, Srikanta S, Eisenbarth G, ''et al.'' |title=Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion. |journal=J. Clin. Endocrinol. Metab. |volume=64 |issue= 1 |pages= 43-50 |year= 1987 |pmid= 3782435 |doi=  }}
* {{cite journal | vauthors = Francke U, Foellmer BE, Haynes BF | title = Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11 | journal = Somatic Cell Genet. | volume = 9 | issue = 3 | pages = 333–44 | year = 1983 | pmid = 6190235 | doi = 10.1007/BF01539142 }}
*{{cite journal | author=Hemler ME, Strominger JL |title=Characterization of antigen recognized by the monoclonal antibody (4F2): different molecular forms on human T and B lymphoblastoid cell lines. |journal=J. Immunol. |volume=129 |issue= 2 |pages= 623-8 |year= 1982 |pmid= 6177771 |doi= }}
* {{cite journal | vauthors = Haynes BF, Hemler ME, Mann DL, Eisenbarth GS, Shelhamer J, Mostowski HS, Thomas CA, Strominger JL, Fauci AS | title = Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes | journal = J. Immunol. | volume = 126 | issue = 4 | pages = 1409–14 | year = 1981 | pmid = 7204970 | doi =  }}
*{{cite journal | author=Peters PG, Kamarck ME, Hemler ME, ''et al.'' |title=Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen. |journal=Somatic Cell Genet. |volume=8 |issue= 6 |pages= 825-34 |year= 1983 |pmid= 6187076 |doi= }}
* {{cite journal | vauthors = Ohgimoto S, Tabata N, Suga S, Nishio M, Ohta H, Tsurudome M, Komada H, Kawano M, Watanabe N, Ito Y | title = Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules | journal = J. Immunol. | volume = 155 | issue = 7 | pages = 3585–92 | year = 1995 | pmid = 7561057 | doi =  }}
*{{cite journal | author=Francke U, Foellmer BE, Haynes BF |title=Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11. |journal=Somatic Cell Genet. |volume=9 |issue= 3 |pages= 333-44 |year= 1983 |pmid= 6190235 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal |author=Haynes BF, Hemler ME, Mann DL, ''et al.'' |title=Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. |journal=J. Immunol. |volume=126 |issue= 4 |pages= 1409-14 |year= 1981 |pmid= 7204970 |doi=  }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Ohgimoto S, Tabata N, Suga S, ''et al.'' |title=Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules. |journal=J. Immunol. |volume=155 |issue= 7 |pages= 3585-92 |year= 1995 |pmid= 7561057 |doi= }}
* {{cite journal | vauthors = Ohgimoto S, Tabata N, Suga S, Tsurudome M, Kawano M, Nishio M, Okamoto K, Komada H, Watanabe N, Ito Y | title = Regulation of human immunodeficiency virus gp160-mediated cell fusion by antibodies against fusion regulatory protein 1 | journal = J. Gen. Virol. | volume = 77 | issue = 11 | pages = 2747–56 | year = 1996 | pmid = 8922468 | doi = 10.1099/0022-1317-77-11-2747 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Courseaux A, Grosgeorge J, Gaudray P, Pannett AA, Forbes SA, Williamson C, Bassett D, Thakker RV, Teh BT, Farnebo F, Shepherd J, Skogseid B, Larsson C, Giraud S, Zhang CX, Salandre J, Calender A | title = Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1) | journal = Genomics | volume = 37 | issue = 3 | pages = 354–65 | year = 1997 | pmid = 8938448 | doi = 10.1006/geno.1996.0570 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-Scale Concatenation cDNA Sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Ohgimoto S, Tabata N, Suga S, ''et al.'' |title=Regulation of human immunodeficiency virus gp160-mediated cell fusion by antibodies against fusion regulatory protein 1. |journal=J. Gen. Virol. |volume=77 ( Pt 11) |issue= |pages= 2747-56 |year= 1996 |pmid= 8922468 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Courseaux A, Grosgeorge J, Gaudray P, ''et al.'' |title=Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). |journal=Genomics |volume=37 |issue= 3 |pages= 354-65 |year= 1997 |pmid= 8938448 |doi=  }}
* {{cite journal | vauthors = Tabata N, Ido M, Suga S, Ohgimoto S, Tsurudome M, Kawano M, Nishio M, Watanabe N, Okamoto K, Komada H, Sakurai M, Ito Y | title = Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160 | journal = Med. Microbiol. Immunol. | volume = 186 | issue = 2–3 | pages = 115–23 | year = 1998 | pmid = 9403839 | doi = 10.1007/s004300050053 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | author=Tabata N, Ido M, Suga S, ''et al.'' |title=Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160. |journal=Med. Microbiol. Immunol. |volume=186 |issue= 2-3 |pages= 115-23 |year= 1998 |pmid= 9403839 |doi=  }}
}}
{{refend}}
{{refend}}


== External links ==
* {{MeshName|Large+Neutral+Amino+Acid-Transporter+1}}
* {{MeshName|Amino+Acid+Transport+System+L}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{PDB Gallery|geneid=6520}}
{{Membrane transport proteins}}
 
{{Solute carrier family|bg|bg0}}
 
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}

Revision as of 06:33, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene.[1][2]

SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98).[3][4]

Function

SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.[5] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.[5]

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene)[6]
  • CD98 light subunit protein encoded by the SLC7A5 gene[7]

Interactions

SLC3A2 has been shown to interact with SLC7A7.[8]

See also

References

  1. ↑ Teixeira S, Di Grandi S, Kühn LC (Aug 1987). "Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus". J Biol Chem. 262 (20): 9574–80. PMID 3036867.
  2. ↑ 2.0 2.1 "Entrez Gene: SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2".
  3. ↑ Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135.
  4. ↑ Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics. 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038.
  5. ↑ 5.0 5.1 Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. doi:10.1073/pnas.96.21.12079. PMC 18415. PMID 10518579.
  6. ↑ Palacín M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.
  7. ↑ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.
  8. ↑ Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F (Jan 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". EMBO J. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

Further reading

External links

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