SLC2A9: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +))
 
m (Bot: HTTP→HTTPS)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Solute carrier family 2, facilitated glucose transporter member 9''' is a [[protein]] that in humans is encoded by the ''SLC2A9'' [[gene]].<ref name="pmid10860667">{{cite journal | vauthors = Phay JE, Hussain HB, Moley JF | title = Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9) | journal = Genomics | volume = 66 | issue = 2 | pages = 217–20 |date=Aug 2000 | pmid = 10860667 | pmc = | doi = 10.1006/geno.2000.6195 }}</ref><ref name="pmid17710649">{{cite journal | vauthors = Manolescu AR, Augustin R, Moley K, Cheeseman C | title = A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity | journal = Mol Membr Biol | volume = 24 | issue = 5-6 | pages = 455–63 |date=Aug 2007 | pmid = 17710649 | pmc = | doi = 10.1080/09687680701298143 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56606| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 2 (facilitated glucose transporter), member 9
| HGNCid = 13446
| Symbol = SLC2A9
| AltSymbols =; GLUT9; GLUTX
| OMIM = 606142
| ECnumber =
| Homologene = 69290
| MGIid = 2152844
| GeneAtlas_image1 = PBB_GE_SLC2A9_219991_at_fs.jpg
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005351 |text = sugar:hydrogen ion symporter activity}} {{GNF_GO|id=GO:0005355 |text = glucose transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}  
| Process = {{GNF_GO|id=GO:0008643 |text = carbohydrate transport}} {{GNF_GO|id=GO:0015758 |text = glucose transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56606
    | Hs_Ensembl = ENSG00000109667
    | Hs_RefseqProtein = NP_001001290
    | Hs_RefseqmRNA = NM_001001290
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 9436946
    | Hs_GenLoc_end = 9650970
    | Hs_Uniprot = Q9NRM0
    | Mm_EntrezGene = 117591
    | Mm_Ensembl = ENSMUSG00000005107
    | Mm_RefseqmRNA = NM_001012363
    | Mm_RefseqProtein = NP_001012363
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 38637555
    | Mm_GenLoc_end = 38790401
    | Mm_Uniprot = 
  }}
}}
{{CMG}}
__NOTOC__


==Overview==
'''Solute carrier family 2 (facilitated glucose transporter), member 9''', also known as '''SLC2A9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56606| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis.  The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56606| accessdate = }}</ref>
| summary_text = This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis.  The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez"/>
}}
}}
SLC2A9 has also recently been found to transport [[uric acid]] and genetic variants of the transporter have been linked to increased risk of development of [[gout]].<ref name="Vitart_2008">{{cite journal | author = Vitart V, Rudan I, Hayward C, ''et al'' | title = SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout | journal = Nature Genetics | volume = 40 | issue = 4 | pages =  | year = 2008 | pmid = | doi = 10.1038/ng.106 | issn = }}</ref><ref name="Döring_2008">{{cite journal | author = Döring A, Gieger C, Mehta D, ''et al'' | title = SLC2A9 influences uric acid concentrations with pronounced sex-specific effects | journal = Nature Genetics | volume = 40 | issue = 4 | pages =  | year = 2008 | pmid = | doi = 10.1038/ng.107 | issn = }}</ref>
 
SLC2A9 has also recently been found to transport [[uric acid]], and genetic variants of the transporter have been linked to increased risk of development of both [[hyperuricemia]], [[gout]] and [[Alzheimer's disease]].<ref name="Vitart_2008">{{cite journal |vauthors=Vitart V, Rudan I, Hayward C, etal | title = SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout | journal = Nature Genetics | volume = 40 | issue = 4 | pages =  437–42| year = 2008 | pmid = 18327257| doi = 10.1038/ng.106 }}</ref><ref name="Döring_2008">{{cite journal |vauthors=Döring A, Gieger C, Mehta D, etal | title = SLC2A9 influences uric acid concentrations with pronounced sex-specific effects | journal = Nature Genetics | volume = 40 | issue = 4 | pages =  430–6| year = 2008 | pmid = 18327256| doi = 10.1038/ng.107 }}</ref><ref name="Hollingworth 2012">{{cite journal  |vauthors=Hollingworth P, Sweet R, Sims R, etal | title = Genome-wide association study of Alzheimer's disease with psychotic symptoms | journal = Molecular Psychiatry | volume = 17 | pages = 1316–1327 | year = 2012 | doi=10.1038/mp.2011.125}}</ref>


==See also==
==See also==
Line 66: Line 19:
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Doege H, Bocianski A, Joost HG, Schürmann A |title=Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. | series=350 |journal=Biochem. J. |volume=Pt 3 |issue=  |pages= 771–6 |year= 2001 |pmid= 10970791 |doi= 10.1042/0264-6021:3500771| pmc=1221309 }}
| citations =
*{{cite journal  | vauthors=Shikhman AR, Brinson DC, Valbracht J, Lotz MK |title=Cytokine regulation of facilitated glucose transport in human articular chondrocytes. |journal=J. Immunol. |volume=167 |issue= 12 |pages= 7001–8 |year= 2001 |pmid= 11739520 |doi=  10.4049/jimmunol.167.12.7001}}
*{{cite journal  | author=Phay JE, Hussain HB, Moley JF |title=Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). |journal=Genomics |volume=66 |issue= 2 |pages= 217-20 |year= 2000 |pmid= 10860667 |doi= 10.1006/geno.2000.6195 }}
*{{cite journal   |vauthors=Mobasheri A, Neama G, Bell S, etal |title=Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. |journal=Cell Biol. Int. |volume=26 |issue= 3 |pages= 297–300 |year= 2002 |pmid= 11991658 |doi= 10.1006/cbir.2001.0850 }}
*{{cite journal  | author=Doege H, Bocianski A, Joost HG, Schürmann A |title=Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. |journal=Biochem. J. |volume=350 Pt 3 |issue=  |pages= 771-6 |year= 2001 |pmid= 10970791 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Shikhman AR, Brinson DC, Valbracht J, Lotz MK |title=Cytokine regulation of facilitated glucose transport in human articular chondrocytes. |journal=J. Immunol. |volume=167 |issue= 12 |pages= 7001-8 |year= 2001 |pmid= 11739520 |doi=  }}
*{{cite journal   |vauthors=Richardson S, Neama G, Phillips T, etal |title=Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. |journal=Osteoarthr. Cartil. |volume=11 |issue= 2 |pages= 92–101 |year= 2003 |pmid= 12554125 |doi=10.1053/joca.2002.0858 }}
*{{cite journal | author=Mobasheri A, Neama G, Bell S, ''et al.'' |title=Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. |journal=Cell Biol. Int. |volume=26 |issue= 3 |pages= 297-300 |year= 2002 |pmid= 11991658 |doi= 10.1006/cbir.2001.0850 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Augustin R, Carayannopoulos MO, Dowd LO, etal |title=Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16229–36 |year= 2004 |pmid= 14739288 |doi= 10.1074/jbc.M312226200 }}
*{{cite journal | author=Richardson S, Neama G, Phillips T, ''et al.'' |title=Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. |journal=Osteoarthr. Cartil. |volume=11 |issue= 2 |pages= 92-101 |year= 2003 |pmid= 12554125 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Augustin R, Carayannopoulos MO, Dowd LO, ''et al.'' |title=Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16229-36 |year= 2004 |pmid= 14739288 |doi= 10.1074/jbc.M312226200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{Solute carrier family|bg|bg0}}


{{NLM content}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]


{{WikiDoc Help Menu}}
 
{{WikiDoc Sources}}
{{membrane-protein-stub}}

Latest revision as of 06:31, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.[1][2][3]

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease.[4][5][6]

See also

References

  1. ↑ Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics. 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667.
  2. ↑ Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol. 24 (5–6): 455–63. doi:10.1080/09687680701298143. PMID 17710649.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9".
  4. ↑ Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics. 40 (4): 437–42. doi:10.1038/ng.106. PMID 18327257.
  5. ↑ Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics. 40 (4): 430–6. doi:10.1038/ng.107. PMID 18327256.
  6. ↑ Hollingworth P, Sweet R, Sims R, et al. (2012). "Genome-wide association study of Alzheimer's disease with psychotic symptoms". Molecular Psychiatry. 17: 1316–1327. doi:10.1038/mp.2011.125.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=SLC2A9&oldid=1413888"