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{{Infobox_gene}}
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'''Calcium-binding mitochondrial carrier protein Aralar1''' is a [[protein]] that in humans is encoded by the ''SLC25A12'' [[gene]].<ref name="pmid9722566">{{cite journal | vauthors = del Arco A, Satrústegui J | title = Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain | journal = The Journal of Biological Chemistry | volume = 273 | issue = 36 | pages = 23327–34 | date = September 1998 | pmid = 9722566 | pmc =  | doi = 10.1074/jbc.273.36.23327 }}</ref><ref name="pmid10702666">{{cite journal | vauthors = Crackower MA, Sinasac DS, Lee JR, Herbrick JA, Tsui LC, Scherer SW | title = Assignment of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24 | journal = Cytogenetics and Cell Genetics | volume = 87 | issue = 3-4 | pages = 197–8 | date = Apr 2000 | pmid = 10702666 | pmc =  | doi = 10.1159/000015465 }}</ref><ref name="pmid11566871">{{cite journal | vauthors = Palmieri L, Pardo B, Lasorsa FM, del Arco A, Kobayashi K, Iijima M, Runswick MJ, Walker JE, Saheki T, Satrústegui J, Palmieri F | title = Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria | journal = The EMBO Journal | volume = 20 | issue = 18 | pages = 5060–9 | date = September 2001 | pmid = 11566871 | pmc = 125626 | doi = 10.1093/emboj/20.18.5060 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8604| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 25 (mitochondrial carrier, Aralar), member 12
| HGNCid = 10982
| Symbol = SLC25A12
| AltSymbols =; ARALAR; ARALAR1
| OMIM = 603667
| ECnumber = 
| Homologene = 48235
| MGIid = 1926080
| GeneAtlas_image1 = PBB_GE_SLC25A12_203340_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC25A12_203339_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0015294 |text = solute:cation symporter activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8604
    | Hs_Ensembl = ENSG00000115840
    | Hs_RefseqProtein = NP_003696
    | Hs_RefseqmRNA = NM_003705
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 172349127
    | Hs_GenLoc_end = 172458991
    | Hs_Uniprot = O75746
    | Mm_EntrezGene = 78830
    | Mm_Ensembl = ENSMUSG00000027010
    | Mm_RefseqmRNA = NM_172436
    | Mm_RefseqProtein = NP_766024
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 71071902
    | Mm_GenLoc_end = 71168588
    | Mm_Uniprot = Q8BH59
  }}
}}
'''Solute carrier family 25 (mitochondrial carrier, Aralar), member 12''', also known as '''SLC25A12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8604| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}
 
==See also==
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kobayashi K, Sinasac DS, Iijima M, Boright AP, Begum L, Lee JR, Yasuda T, Ikeda S, Hirano R, Terazono H, Crackower MA, Kondo I, Tsui LC, Scherer SW, Saheki T | title = The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein | journal = Nature Genetics | volume = 22 | issue = 2 | pages = 159–63 | date = June 1999 | pmid = 10369257 | doi = 10.1038/9667 }}
| citations =
* {{cite journal | vauthors = Sanz R, del Arco A, Ayuso C, Ramos C, Satrústegui J | title = Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 89 | issue = 3-4 | pages = 143–4 | year = 2000 | pmid = 10965105 | doi = 10.1159/000015595 }}
*{{cite journal | author=del Arco A, Satrústegui J |title=Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23327-34 |year= 1998 |pmid= 9722566 |doi=  }}
* {{cite journal | vauthors = Ramoz N, Reichert JG, Smith CJ, Silverman JM, Bespalova IN, Davis KL, Buxbaum JD | title = Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism | journal = The American Journal of Psychiatry | volume = 161 | issue = 4 | pages = 662–9 | date = April 2004 | pmid = 15056512 | doi = 10.1176/appi.ajp.161.4.662 }}
*{{cite journal  | author=Kobayashi K, Sinasac DS, Iijima M, ''et al.'' |title=The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein. |journal=Nat. Genet. |volume=22 |issue= 2 |pages= 159-63 |year= 1999 |pmid= 10369257 |doi= 10.1038/9667 }}
* {{cite journal | vauthors = Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P | title = The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 53 | pages = 55659–66 | date = December 2004 | pmid = 15494407 | doi = 10.1074/jbc.M409303200 }}
*{{cite journal | author=Crackower MA, Sinasac DS, Lee JR, ''et al.'' |title=Assignment of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 197-8 |year= 2000 |pmid= 10702666 |doi=  }}
* {{cite journal | vauthors = Rabionet R, McCauley JL, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS, Haines JL, DeLong GR, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Pericak-Vance MA | title = Lack of association between autism and SLC25A12 | journal = The American Journal of Psychiatry | volume = 163 | issue = 5 | pages = 929–31 | date = May 2006 | pmid = 16648338 | doi = 10.1176/appi.ajp.163.5.929 }}
*{{cite journal  | author=Sanz R, del Arco A, Ayuso C, ''et al.'' |title=Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 143-4 |year= 2000 |pmid= 10965105 |doi=  }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Palmieri L, Pardo B, Lasorsa FM, ''et al.'' |title=Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria. |journal=EMBO J. |volume=20 |issue= 18 |pages= 5060-9 |year= 2001 |pmid= 11566871 |doi= 10.1093/emboj/20.18.5060 }}
* {{cite journal | vauthors = Hong CJ, Liou YJ, Liao DL, Hou SJ, Yen FC, Tsai SJ | title = Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 31 | issue = 7 | pages = 1510–3 | date = October 2007 | pmid = 17693006 | doi = 10.1016/j.pnpbp.2007.07.010 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ramoz N, Reichert JG, Smith CJ, ''et al.'' |title=Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. |journal=The American journal of psychiatry |volume=161 |issue= 4 |pages= 662-9 |year= 2004 |pmid= 15056512 |doi= }}
*{{cite journal | author=Rubi B, del Arco A, Bartley C, ''et al.'' |title=The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55659-66 |year= 2005 |pmid= 15494407 |doi= 10.1074/jbc.M409303200 }}
*{{cite journal | author=Rabionet R, McCauley JL, Jaworski JM, ''et al.'' |title=Lack of association between autism and SLC25A12. |journal=The American journal of psychiatry |volume=163 |issue= 5 |pages= 929-31 |year= 2006 |pmid= 16648338 |doi= 10.1176/appi.ajp.163.5.929 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Hong CJ, Liou YJ, Liao DL, ''et al.'' |title=Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia. |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=31 |issue= 7 |pages= 1510-3 |year= 2007 |pmid= 17693006 |doi= 10.1016/j.pnpbp.2007.07.010 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
[[Category:EF-hand-containing proteins]]
 
{{membrane-protein-stub}}

Revision as of 06:29, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcium-binding mitochondrial carrier protein Aralar1 is a protein that in humans is encoded by the SLC25A12 gene.[1][2][3][4]

See also

References

  1. ↑ del Arco A, Satrústegui J (September 1998). "Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain". The Journal of Biological Chemistry. 273 (36): 23327–34. doi:10.1074/jbc.273.36.23327. PMID 9722566.
  2. ↑ Crackower MA, Sinasac DS, Lee JR, Herbrick JA, Tsui LC, Scherer SW (Apr 2000). "Assignment of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24". Cytogenetics and Cell Genetics. 87 (3–4): 197–8. doi:10.1159/000015465. PMID 10702666.
  3. ↑ Palmieri L, Pardo B, Lasorsa FM, del Arco A, Kobayashi K, Iijima M, Runswick MJ, Walker JE, Saheki T, Satrústegui J, Palmieri F (September 2001). "Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria". The EMBO Journal. 20 (18): 5060–9. doi:10.1093/emboj/20.18.5060. PMC 125626. PMID 11566871.
  4. ↑ "Entrez Gene: SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12".

Further reading

  • Kobayashi K, Sinasac DS, Iijima M, Boright AP, Begum L, Lee JR, Yasuda T, Ikeda S, Hirano R, Terazono H, Crackower MA, Kondo I, Tsui LC, Scherer SW, Saheki T (June 1999). "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein". Nature Genetics. 22 (2): 159–63. doi:10.1038/9667. PMID 10369257.
  • Sanz R, del Arco A, Ayuso C, Ramos C, Satrústegui J (2000). "Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 143–4. doi:10.1159/000015595. PMID 10965105.
  • Ramoz N, Reichert JG, Smith CJ, Silverman JM, Bespalova IN, Davis KL, Buxbaum JD (April 2004). "Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism". The American Journal of Psychiatry. 161 (4): 662–9. doi:10.1176/appi.ajp.161.4.662. PMID 15056512.
  • Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P (December 2004). "The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells". The Journal of Biological Chemistry. 279 (53): 55659–66. doi:10.1074/jbc.M409303200. PMID 15494407.
  • Rabionet R, McCauley JL, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS, Haines JL, DeLong GR, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Pericak-Vance MA (May 2006). "Lack of association between autism and SLC25A12". The American Journal of Psychiatry. 163 (5): 929–31. doi:10.1176/appi.ajp.163.5.929. PMID 16648338.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Hong CJ, Liou YJ, Liao DL, Hou SJ, Yen FC, Tsai SJ (October 2007). "Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31 (7): 1510–3. doi:10.1016/j.pnpbp.2007.07.010. PMID 17693006.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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