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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Solute carrier family 22 member 18''' is a [[protein]] that in humans is encoded by the ''SLC22A18'' [[gene]].<ref name="pmid9499412">{{cite journal | vauthors = Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B | title = IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes | journal = Human Molecular Genetics | volume = 7 | issue = 4 | pages = 597–608 | date = April 1998 | pmid = 9499412 | pmc =  | doi = 10.1093/hmg/7.4.597 }}</ref><ref name="pmid9520460">{{cite journal | vauthors = Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M | title = Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 7 | pages = 3873–8 | date = March 1998 | pmid = 9520460 | pmc = 19930 | doi = 10.1073/pnas.95.7.3873 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 22 (organic cation transporter), member 18
| HGNCid = 10964
| Symbol = SLC22A18
| AltSymbols =; BWR1A; BWSCR1A; DKFZp667A184; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A
| OMIM = 602631
| ECnumber = 
| Homologene = 1918
| MGIid = 1336884
| GeneAtlas_image1 = PBB_GE_SLC22A18_204981_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015101 |text = organic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015520 |text = tetracycline:hydrogen antiporter activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0015904 |text = tetracycline transport}} {{GNF_GO|id=GO:0042493 |text = response to drug}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5002
    | Hs_Ensembl = ENSG00000110628
    | Hs_RefseqProtein = NP_002546
    | Hs_RefseqmRNA = NM_002555
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 2877527
    | Hs_GenLoc_end = 2903052
    | Hs_Uniprot = Q96BI1
    | Mm_EntrezGene = 18400
    | Mm_Ensembl = ENSMUSG00000000154
    | Mm_RefseqmRNA = NM_001042760
    | Mm_RefseqProtein = NP_001036225
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 143283179
    | Mm_GenLoc_end = 143308712
    | Mm_Uniprot = Q05DG8
  }}
}}
'''Solute carrier family 22 (organic cation transporter), member 18''', also known as '''SLC22A18''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Akiyama S | title = [Mechanisms of drug resistance and reversal of the resistance] | journal = Human Cell | volume = 14 | issue = 4 | pages = 257–60 | date = December 2001 | pmid = 11925925 | doi =  }}
| citations =
* {{cite journal | vauthors = Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, Reece M, Prawitt D, Landers J, Housman DE, Winterpacht A, Zabel BU, Pelletier J, Weissman BE, Shows TB, Higgins MJ | title = Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain | journal = Genomics | volume = 49 | issue = 1 | pages = 38–51 | date = April 1998 | pmid = 9570947 | doi = 10.1006/geno.1998.5221 }}
*{{cite journal | author=Akiyama S |title=[Mechanisms of drug resistance and reversal of the resistance] |journal=Hum. Cell |volume=14 |issue= 4 |pages= 257-60 |year= 2002 |pmid= 11925925 |doi=  }}
* {{cite journal | vauthors = Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J | title = Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules | journal = FEBS Letters | volume = 433 | issue = 3 | pages = 245–50 | date = August 1998 | pmid = 9744804 | doi = 10.1016/S0014-5793(98)00907-7 }}
*{{cite journal | author=Dao D, Frank D, Qian N, ''et al.'' |title=IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 597-608 |year= 1998 |pmid= 9499412 |doi=  }}
* {{cite journal | vauthors = Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu RJ, Brandenburg S, Lee MJ, Miller G, Feinberg AP | title = Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5 | journal = Cancer Research | volume = 58 | issue = 18 | pages = 4155–9 | date = September 1998 | pmid = 9751628 | doi =  }}
*{{cite journal  | author=Schwienbacher C, Sabbioni S, Campi M, ''et al.'' |title=Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3873-8 |year= 1998 |pmid= 9520460 |doi=  }}
* {{cite journal | vauthors = Morisaki H, Hatada I, Morisaki T, Mukai T | title = A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice | journal = DNA Research | volume = 5 | issue = 4 | pages = 235–40 | date = August 1998 | pmid = 9802569 | doi = 10.1093/dnares/5.4.235 }}
*{{cite journal  | author=Cooper PR, Smilinich NJ, Day CD, ''et al.'' |title=Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. |journal=Genomics |volume=49 |issue= 1 |pages= 38-51 |year= 1998 |pmid= 9570947 |doi= 10.1006/geno.1998.5221 }}
* {{cite journal | vauthors = Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP | title = Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain | journal = Genome Research | volume = 10 | issue = 11 | pages = 1697–710 | date = November 2000 | pmid = 11076855 | doi = 10.1101/gr.161800 }}
*{{cite journal | author=Reece M, Prawitt D, Landers J, ''et al.'' |title=Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules. |journal=FEBS Lett. |volume=433 |issue= 3 |pages= 245-50 |year= 1998 |pmid= 9744804 |doi= }}
* {{cite journal | vauthors = Yamada HY, Gorbsky GJ | title = Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 | journal = Oncogene | volume = 25 | issue = 9 | pages = 1330–9 | date = March 2006 | pmid = 16314844 | pmc = 2713668 | doi = 10.1038/sj.onc.1209167 }}
*{{cite journal | author=Lee MP, Reeves C, Schmitt A, ''et al.'' |title=Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5. |journal=Cancer Res. |volume=58 |issue= 18 |pages= 4155-9 |year= 1998 |pmid= 9751628 |doi=  }}
* {{cite journal | vauthors = Gallagher E, Mc Goldrick A, Chung WY, Mc Cormack O, Harrison M, Kerin M, Dervan PA, Mc Cann A | title = Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer | journal = Genomics | volume = 88 | issue = 1 | pages = 12–7 | date = July 2006 | pmid = 16624517 | doi = 10.1016/j.ygeno.2006.02.004 }}
*{{cite journal | author=Morisaki H, Hatada I, Morisaki T, Mukai T |title=A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice. |journal=DNA Res. |volume=5 |issue= 4 |pages= 235-40 |year= 1999 |pmid= 9802569 |doi= }}
*{{cite journal | author=Onyango P, Miller W, Lehoczky J, ''et al.'' |title=Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1697-710 |year= 2001 |pmid= 11076855 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Yamada HY, Gorbsky GJ |title=Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. |journal=Oncogene |volume=25 |issue= 9 |pages= 1330-9 |year= 2006 |pmid= 16314844 |doi= 10.1038/sj.onc.1209167 }}
*{{cite journal | author=Gallagher E, Mc Goldrick A, Chung WY, ''et al.'' |title=Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer. |journal=Genomics |volume=88 |issue= 1 |pages= 12-7 |year= 2006 |pmid= 16624517 |doi= 10.1016/j.ygeno.2006.02.004 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}

Latest revision as of 03:17, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]

Function

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]

See also

References

  1. ↑ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (April 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Human Molecular Genetics. 7 (4): 597–608. doi:10.1093/hmg/7.4.597. PMID 9499412.
  2. ↑ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (March 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proceedings of the National Academy of Sciences of the United States of America. 95 (7): 3873–8. doi:10.1073/pnas.95.7.3873. PMC 19930. PMID 9520460.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18".

Further reading

  • Akiyama S (December 2001). "[Mechanisms of drug resistance and reversal of the resistance]". Human Cell. 14 (4): 257–60. PMID 11925925.
  • Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, Reece M, Prawitt D, Landers J, Housman DE, Winterpacht A, Zabel BU, Pelletier J, Weissman BE, Shows TB, Higgins MJ (April 1998). "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain". Genomics. 49 (1): 38–51. doi:10.1006/geno.1998.5221. PMID 9570947.
  • Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J (August 1998). "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules". FEBS Letters. 433 (3): 245–50. doi:10.1016/S0014-5793(98)00907-7. PMID 9744804.
  • Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu RJ, Brandenburg S, Lee MJ, Miller G, Feinberg AP (September 1998). "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5". Cancer Research. 58 (18): 4155–9. PMID 9751628.
  • Morisaki H, Hatada I, Morisaki T, Mukai T (August 1998). "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice". DNA Research. 5 (4): 235–40. doi:10.1093/dnares/5.4.235. PMID 9802569.
  • Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP (November 2000). "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain". Genome Research. 10 (11): 1697–710. doi:10.1101/gr.161800. PMID 11076855.
  • Yamada HY, Gorbsky GJ (March 2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene. 25 (9): 1330–9. doi:10.1038/sj.onc.1209167. PMC 2713668. PMID 16314844.
  • Gallagher E, Mc Goldrick A, Chung WY, Mc Cormack O, Harrison M, Kerin M, Dervan PA, Mc Cann A (July 2006). "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer". Genomics. 88 (1): 12–7. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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