SLC22A1

Solute carrier family 22 (organic cation transporter), member 1
Identifiers
Symbols	SLC22A1 ; OCT1; HOCT1; oct1_cds
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20665
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC22A1 207201 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 22 (organic cation transporter), member 1, also known as SLC22A1, is a human gene.

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.

See also

• Solute carrier family

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMID 1727476.
• Jeang KT, Chun R, Lin NH; et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMID 7690421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. PMID 8902060.CS1 maint: Multiple names: authors list (link)
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 ( Pt 1): 155–8. PMID 9078256.
• Zhang L, Dresser MJ, Gray AT; et al. (1997). "Cloning and functional expression of a human liver organic cation transporter". Mol. Pharmacol. 51 (6): 913–21. PMID 9187257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorboulev V, Ulzheimer JC, Akhoundova A; et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. PMID 9260930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koehler MR, Wissinger B, Gorboulev V; et al. (1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet. Cell Genet. 79 (3–4): 198–200. PMID 9605850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.CS1 maint: Multiple names: authors list (link)
• Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. PMID 10541551.CS1 maint: Multiple names: authors list (link)
• Tomilin A, Reményi A, Lins K; et al. (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell. 103 (6): 853–64. PMID 11136971.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayer M, Bönisch H, Brüss M (2001). "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)". Ann. Hum. Genet. 63 (Pt 6): 473–82. doi:10.1017/S0003480099007770. PMID 11388889.CS1 maint: Multiple names: authors list (link)
• Pietig G, Mehrens T, Hirsch JR; et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pan H, Qin WX, Huo KK; et al. (2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics. 77 (1–2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu XR, Huang J, Xu ZG; et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schinkel AH, Jonker JW (2003). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics. 12 (8): 589–90. PMID 12439217.
• Kerb R, Brinkmann U, Chatskaia N; et al. (2003). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics. 12 (8): 591–5. PMID 12439218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schaffer A, Kim EC, Wu X; et al. (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shu Y, Leabman MK, Feng B; et al. (2003). "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5902–7. doi:10.1073/pnas.0730858100. PMID 12719534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakata T, Anzai N, Shin HJ; et al. (2004). "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions". Biochem. Biophys. Res. Commun. 313 (3): 789–93. PMID 14697261.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bottalico B, Larsson I, Brodszki J; et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.