SLC17A7
| Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SLC17A7 ; BNPI; VGLUT1 | ||||||||||
| External IDs | Template:OMIM5 HomoloGene: 69302 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC17A7 204230 s at tn.png | |||||||||||
| File:PBB GE SLC17A7 204229 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, also known as SLC17A7, is a human gene.[1]
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[1]
See also
References
Further reading
- Ni B, Du Y, Wu X; et al. (1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J. Neurochem. 66 (6): 2227–38. PMID 8632143.
- Aihara Y, Mashima H, Onda H; et al. (2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J. Neurochem. 74 (6): 2622–5. PMID 10820226.
- Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. PMID 10938000.
- Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. doi:10.1038/35025070. PMID 11001057.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259.
- Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236.
- Vinatier J, Herzog E, Plamont MA; et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361.
- Almqvist J, Huang Y, Laaksonen A; et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMID 17660252.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.