RHCG: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Rh family, C glycoprotein''', also known as '''RHCG''', is a [[protein]] that in humans is encoded by the ''RHCG'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHCG Rh family, C glycoprotein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51458| accessdate = }}</ref><ref name="pmid10852913">{{cite journal | vauthors = Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH | title = Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25641–51 |date=August 2000 | pmid = 10852913 | doi = 10.1074/jbc.M003353200 | url = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Rh family, C glycoprotein
| HGNCid = 18140
| Symbol = RHCG
| AltSymbols =; C15orf6; PDRC2; RHGK
| OMIM = 605381
| ECnumber = 
| Homologene = 32310
| MGIid = 1888517
| GeneAtlas_image1 = PBB_GE_RHCG_219554_at_tn.png
| Function = {{GNF_GO|id=GO:0008519 |text = ammonium transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
| Process = {{GNF_GO|id=GO:0006873 |text = cell ion homeostasis}} {{GNF_GO|id=GO:0015696 |text = ammonium transport}} {{GNF_GO|id=GO:0015837 |text = amine transport}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0042592 |text = homeostatic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51458
    | Hs_Ensembl = ENSG00000140519
    | Hs_RefseqProtein = NP_057405
    | Hs_RefseqmRNA = NM_016321
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 87815646
    | Hs_GenLoc_end = 87840818
    | Hs_Uniprot = 
    | Mm_EntrezGene = 56315
    | Mm_Ensembl = ENSMUSG00000030549
    | Mm_RefseqmRNA = NM_019799
    | Mm_RefseqProtein = NP_062773
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 79466882
    | Mm_GenLoc_end = 79491170
    | Mm_Uniprot = 
  }}
}}
'''Rh family, C glycoprotein''', also known as '''RHCG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RHCG Rh family, C glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51458| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RHCG plays a critical role in [[ammonium]] handling and pH [[homeostasis]] in the kidney.<ref name="pmid19020613">{{cite journal | vauthors = Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM | title = A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility | journal = Nature | volume = 456 | issue = 7220 | pages = 339–43 |date=November 2008 | pmid = 19020613 | doi = 10.1038/nature07518 | url = }}</ref> The structure of the RHCG protein<ref name="pmid20457942">{{PDB|3hd6}}; {{cite journal | vauthors = Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM | title = Function of human Rh based on structure of RhCG at 2.1 A | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 107 | issue = 21 | pages = 9638–43 |date=May 2010 | pmid = 20457942 | pmc = 2906887 | doi = 10.1073/pnas.1003587107 }}</ref> indicates that it has a hydrophobic [[ammonia]]-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an [[ammonia transporter]].
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Bakouh N, Benjelloun F, Cherif-Zahar B, Planelles G |title=The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 139–46 |year= 2006 |pmid= 16564724 |doi= 10.1016/j.tracli.2006.02.008 }}
| citations =
*{{cite journal   |vauthors=Zidi-Yahiaoui N, Ripoche P, Le Van Kim C, etal |title=Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 128–31 |year= 2006 |pmid= 16580862 |doi= 10.1016/j.tracli.2006.02.025 }}
*{{cite journal  | author=Bakouh N, Benjelloun F, Cherif-Zahar B, Planelles G |title=The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 139-46 |year= 2006 |pmid= 16564724 |doi= 10.1016/j.tracli.2006.02.008 }}
*{{cite journal   |vauthors=Ridgwell K, Spurr NK, Laguda B, etal |title=Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression. |journal=Biochem. J. |volume=287 |issue=  1|pages= 223–8 |year= 1992 |pmid= 1417776 |doi= | pmc=1133147 }}
*{{cite journal | author=Zidi-Yahiaoui N, Ripoche P, Le Van Kim C, ''et al.'' |title=Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 128-31 |year= 2006 |pmid= 16580862 |doi= 10.1016/j.tracli.2006.02.025 }}
*{{cite journal   |vauthors=Liu Z, Chen Y, Mo R, etal |title=Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25641–51 |year= 2000 |pmid= 10852913 |doi= 10.1074/jbc.M003353200 }}
*{{cite journal | author=Ridgwell K, Spurr NK, Laguda B, ''et al.'' |title=Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression. |journal=Biochem. J. |volume=287 ( Pt 1) |issue=  |pages= 223-8 |year= 1992 |pmid= 1417776 |doi=  }}
*{{cite journal   |vauthors=Marini AM, Matassi G, Raynal V, etal |title=The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. |journal=Nat. Genet. |volume=26 |issue= 3 |pages= 341–4 |year= 2000 |pmid= 11062476 |doi= 10.1038/81656 }}
*{{cite journal | author=Liu Z, Chen Y, Mo R, ''et al.'' |title=Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25641-51 |year= 2000 |pmid= 10852913 |doi= 10.1074/jbc.M003353200 }}
*{{cite journal   |vauthors=Chen BS, Xu ZX, Xu X, etal |title=RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. |journal=Eur. J. Cancer |volume=38 |issue= 14 |pages= 1927–36 |year= 2002 |pmid= 12204676 |doi=10.1016/S0959-8049(02)00190-9 }}
*{{cite journal | author=Marini AM, Matassi G, Raynal V, ''et al.'' |title=The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. |journal=Nat. Genet. |volume=26 |issue= 3 |pages= 341-4 |year= 2000 |pmid= 11062476 |doi= 10.1038/81656 }}
*{{cite journal   |vauthors=Verlander JW, Miller RT, Frank AE, etal |title=Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F323–37 |year= 2003 |pmid= 12388412 |doi= 10.1152/ajprenal.00050.2002 }}
*{{cite journal | author=Chen BS, Xu ZX, Xu X, ''et al.'' |title=RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia. |journal=Eur. J. Cancer |volume=38 |issue= 14 |pages= 1927-36 |year= 2002 |pmid= 12204676 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Verlander JW, Miller RT, Frank AE, ''et al.'' |title=Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F323-37 |year= 2003 |pmid= 12388412 |doi= 10.1152/ajprenal.00050.2002 }}
*{{cite journal   |vauthors=Nicolas V, Le Van Kim C, Gane P, etal |title=Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25526–33 |year= 2003 |pmid= 12719424 |doi= 10.1074/jbc.M302816200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hemker MB, Cheroutre G, van Zwieten R, etal |title=The Rh complex exports ammonium from human red blood cells. |journal=Br. J. Haematol. |volume=122 |issue= 2 |pages= 333–40 |year= 2003 |pmid= 12846905 |doi=10.1046/j.1365-2141.2003.04425.x }}
*{{cite journal | author=Nicolas V, Le Van Kim C, Gane P, ''et al.'' |title=Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25526-33 |year= 2003 |pmid= 12719424 |doi= 10.1074/jbc.M302816200 }}
*{{cite journal   |vauthors=Bakouh N, Benjelloun F, Hulin P, etal |title=NH<sub>3</sub> is involved in the NH<sub>4</sub><sup>+</sup> transport induced by the functional expression of the human Rh C glycoprotein. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 15975–83 |year= 2004 |pmid= 14761968 |doi= 10.1074/jbc.M308528200 }}
*{{cite journal | author=Hemker MB, Cheroutre G, van Zwieten R, ''et al.'' |title=The Rh complex exports ammonium from human red blood cells. |journal=Br. J. Haematol. |volume=122 |issue= 2 |pages= 333-40 |year= 2003 |pmid= 12846905 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Bakouh N, Benjelloun F, Hulin P, ''et al.'' |title=NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 15975-83 |year= 2004 |pmid= 14761968 |doi= 10.1074/jbc.M308528200 }}
*{{cite journal   |vauthors=Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, etal |title=Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. |journal=Biochem. J. |volume=391 |issue= Pt 1 |pages= 33–40 |year= 2006 |pmid= 15929723 |doi= 10.1042/BJ20050657 | pmc=1237136 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Huang CH, Peng J |title=Evolutionary conservation and diversification of Rh family genes and proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 43 |pages= 15512–7 |year= 2005 |pmid= 16227429 |doi= 10.1073/pnas.0507886102 | pmc=1266151 }}
*{{cite journal | author=Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, ''et al.'' |title=Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells. |journal=Biochem. J. |volume=391 |issue= Pt 1 |pages= 33-40 |year= 2006 |pmid= 15929723 |doi= 10.1042/BJ20050657 }}
*{{cite journal   |vauthors=Marini AM, Boeckstaens M, Benjelloun F, etal |title=Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. |journal=Curr. Genet. |volume=49 |issue= 6 |pages= 364–74 |year= 2006 |pmid= 16477434 |doi= 10.1007/s00294-006-0062-5 }}
*{{cite journal  | author=Huang CH, Peng J |title=Evolutionary conservation and diversification of Rh family genes and proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 43 |pages= 15512-7 |year= 2005 |pmid= 16227429 |doi= 10.1073/pnas.0507886102 }}
*{{cite journal | author=Marini AM, Boeckstaens M, Benjelloun F, ''et al.'' |title=Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. |journal=Curr. Genet. |volume=49 |issue= 6 |pages= 364-74 |year= 2006 |pmid= 16477434 |doi= 10.1007/s00294-006-0062-5 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Membrane transport proteins}}
{{WikiDoc Sources}}
 
[[Category:Solute carrier family]]
 
 
{{membrane-protein-stub}}

Latest revision as of 09:11, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[1][2]

Function

RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[3] The structure of the RHCG protein[4] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.

References

  1. ↑ "Entrez Gene: RHCG Rh family, C glycoprotein".
  2. ↑ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
  3. ↑ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature. 456 (7220): 339–43. doi:10.1038/nature07518. PMID 19020613.
  4. ↑ PDB: 3hd6​; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. doi:10.1073/pnas.1003587107. PMC 2906887. PMID 20457942.

Further reading


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