Polycystic kidney disease epidemiology and demographics: Difference between revisions

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{{Polycystic kidney disease}}
{{Polycystic kidney disease}}
{{CMG}}; {{AE}} [[User:Sergekorjian|Serge Korjian]], [[User:YazanDaaboul|Yazan Daaboul]]
{{CMG}}; {{AE}}{{MKA}}, [[User:Sergekorjian|Serge Korjian]], [[User:YazanDaaboul|Yazan Daaboul]]


==Overview==
==Overview==
ADPKD affects approximately 1 in 1000 individuals although prevalence varies according to countries and certain microsattelite regions with a heavy concentration of PKD mutations.
The [[prevalence]] of autosomal dominant polycystic kidney disease (ADPKD) is approximately 100 - 250 per 100,000 individuals in the United States. The [[prevalence]] of ADPKD varies in different countries. The [[prevalence]] of autosomal recessive polycystic kidney disease (ARPKD) is approximately 5 per 100,000 children in the United States. The [[incidence]] increases with age for ADPKD. ARPKD commonly affects infants and children. Males and females are equally affected by ADPKD.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
*The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals in the United States.
*In 1957, the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
===Prevalence===
===Prevalence===
*The prevalence of polycystic kidney disease is approximately 100 - 250 per 100,000 individuals in the United States.
*The [[prevalence]] of autosomal dominant polycystic kidney disease (ADPKD) is approximately 100 - 250 per 100,000 individuals in the United States.<ref name="pmid6846334">{{cite journal |vauthors=Iglesias CG, Torres VE, Offord KP, Holley KE, Beard CM, Kurland LT |title=Epidemiology of adult polycystic kidney disease, Olmsted County, Minnesota: 1935-1980 |journal=Am. J. Kidney Dis. |volume=2 |issue=6 |pages=630–9 |date=May 1983 |pmid=6846334 |doi= |url=}}</ref><ref name="pmid8321262">{{cite journal |vauthors=Gabow PA |title=Autosomal dominant polycystic kidney disease |journal=N. Engl. J. Med. |volume=329 |issue=5 |pages=332–42 |date=July 1993 |pmid=8321262 |doi=10.1056/NEJM199307293290508 |url=}}</ref><ref name="pmid10972657">{{cite journal |vauthors=Levy M, Feingold J |title=Estimating prevalence in single-gene kidney diseases progressing to renal failure |journal=Kidney Int. |volume=58 |issue=3 |pages=925–43 |date=September 2000 |pmid=10972657 |doi=10.1046/j.1523-1755.2000.00250.x |url=}}</ref>
*In 2013, the prevalence of polycystic kidney disease was estimated to be 33 cases per 100,000 individuals in Germany.
*In 2013, the [[prevalence]] of autosomal dominant polycystic kidney disease was estimated to be 33 cases per 100,000 individuals in Germany.<ref name="pmid23300259">{{cite journal| author=Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B et al.| title=Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. | journal=Nephrol Dial Transplant | year= 2013 | volume= 28 | issue= 6 | pages= 1472-87 | pmid=23300259 | doi=10.1093/ndt/gfs551 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23300259 }} </ref>
*In 1998, the prevalence of polycystic kidney disease was estimated to be 25 cases per 100,000 individuals in Japan.
*In 1998, the [[prevalence]] of autosomal dominant polycystic kidney disease was estimated to be 25 cases per 100,000 individuals in Japan.<ref name="pmid9832641">{{cite journal| author=Higashihara E, Nutahara K, Kojima M, Tamakoshi A, Yoshiyuki O, Sakai H et al.| title=Prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease in Japan. | journal=Nephron | year= 1998 | volume= 80 | issue= 4 | pages= 421-7 | pmid=9832641 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9832641 }} </ref>
*In 1996, the prevalence of polycystic kidney disease was estimated to be 90 cases per 100,000 individuals in France.
*In 1996, the [[prevalence]] of autosomal dominant polycystic kidney disease was estimated to be 90 cases per 100,000 individuals in France.<ref name="pmid8838759">{{cite journal| author=Simon P, Le Goff JY, Ang KS, Charasse C, Le Cacheux P, Cam G| title=[Epidemiologic data, clinical and prognostic features of autosomal dominant polycystic kidney disease in a French region]. | journal=Nephrologie | year= 1996 | volume= 17 | issue= 2 | pages= 123-30 | pmid=8838759 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8838759 }} </ref>
*In 1991, the prevalence of polycystic kidney disease was estimated to be 41 cases per 100,000 individuals in United Kingdom.
*In 1991, the [[prevalence]] of autosomal dominant polycystic kidney disease was estimated to be 41 cases per 100,000 individuals in United Kingdom.<ref name="pmid1946928">{{cite journal| author=Davies F, Coles GA, Harper PS, Williams AJ, Evans C, Cochlin D| title=Polycystic kidney disease re-evaluated: a population-based study. | journal=Q J Med | year= 1991 | volume= 79 | issue= 290 | pages= 477-85 | pmid=1946928 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1946928 }} </ref>
*In 1957, the prevalence of polycystic kidney disease was estimated to be 100 cases per 100,000 individuals in Denmark.
*In 1957, the [[prevalence]] of autosomal dominant polycystic kidney disease was estimated to be 100 cases per 100,000 individuals in Denmark.<ref name="pmid13469269‎">{{cite journal| author=DALGAARD OZ| title=Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families. | journal=Acta Med Scand Suppl | year= 1957 | volume= 328 | issue= | pages= 1-255 | pmid=13469269‎ | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13469269 }} </ref>
*The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
*The [[prevalence]] of autosomal recessive polycystic kidney disease (ARPKD) is approximately 5 per 100,000 children in the United States.<ref name="pmid12728091">{{cite journal |vauthors=Guay-Woodford LM, Desmond RA |title=Autosomal recessive polycystic kidney disease: the clinical experience in North America |journal=Pediatrics |volume=111 |issue=5 Pt 1 |pages=1072–80 |date=May 2003 |pmid=12728091 |doi= |url=}}</ref>
 
===Case-fatality rate/Mortality rate===
*In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
*The case-fatality rate/mortality rate of [disease name] is approximately [number range].


===Age===
===Age===
*Patients of all age groups may develop [disease name].
*The [[incidence]] of ADPKD increases with age; the average age at diagnosis is 30 - 50 years.<ref name="pmid8321262">{{cite journal |vauthors=Gabow PA |title=Autosomal dominant polycystic kidney disease |journal=N. Engl. J. Med. |volume=329 |issue=5 |pages=332–42 |date=July 1993 |pmid=8321262 |doi=10.1056/NEJM199307293290508 |url=}}</ref>
*The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
*ARPKD commonly affects infants and children.<ref name="pmid12728091">{{cite journal |vauthors=Guay-Woodford LM, Desmond RA |title=Autosomal recessive polycystic kidney disease: the clinical experience in North America |journal=Pediatrics |volume=111 |issue=5 Pt 1 |pages=1072–80 |date=May 2003 |pmid=12728091 |doi= |url=}}</ref>
*[Disease name] commonly affects individuals younger than/older than [number of years] years of age.  
*[Chronic disease name] is usually first diagnosed among [age group].
*[Acute disease name] commonly affects [age group].


===Race===
===Race===
*There is no racial predilection to [disease name].
*There is no racial predilection to autosomal dominant polycystic kidney disease.
*[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].


===Gender===
===Gender===
*[Disease name] affects men and women equally.
*Autosomal dominant polycystic kidney disease affects men and women equally.<ref name="pmid17434405">{{cite journal| author=Torres VE, Harris PC, Pirson Y| title=Autosomal dominant polycystic kidney disease. | journal=Lancet | year= 2007 | volume= 369 | issue= 9569 | pages= 1287-301 | pmid=17434405 | doi=10.1016/S0140-6736(07)60601-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17434405 }} </ref>
*[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.
 
===Region===
*The majority of [disease name] cases are reported in [geographical region].
 
*[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
 
===Developed Countries===
 
===Developing Countries===
 
ADPKD is a disorder found worldwide and in all ethnic groups. Prevalence is slightly lower in African Americans with fewer cases of ESRD attributed to ADPKD than in Caucasian or Asian individuals. Prevalence is roughly equal among males and females. The table below summarizes the estimated prevalence in selected countries based on available epidemiologic studies.<ref name="pmid17434405">{{cite journal| author=Torres VE, Harris PC, Pirson Y| title=Autosomal dominant polycystic kidney disease. | journal=Lancet | year= 2007 | volume= 369 | issue= 9569 | pages= 1287-301 | pmid=17434405 | doi=10.1016/S0140-6736(07)60601-1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17434405 }} </ref>
 
{| border="1" style="border-collapse:collapse; text-align:center;" cellpadding="5" align="center" width="600px"
|+ '''''Prevalence of ADPKD'''''
| bgcolor="#d9ff54"|'''Country''' || bgcolor="#d9ff54"|'''Prevalence''' || bgcolor="#d9ff54"|'''Article'''
|-
| bgcolor="#ececec"| '''USA''' || 1 in 400-1000 || Iglesias et al, 1983<ref name="pmid6846334">{{cite journal| author=Iglesias CG, Torres VE, Offord KP, Holley KE, Beard CM, Kurland LT| title=Epidemiology of adult polycystic kidney disease, Olmsted County, Minnesota: 1935-1980. | journal=Am J Kidney Dis | year= 1983 | volume= 2 | issue= 6 | pages= 630-9 | pmid=6846334 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6846334 }} </ref>
|-
| bgcolor="#ececec"|'''Denmark''' || 1 in 1000 || Dalgaard, 1957<ref name="pmid13469269‎">{{cite journal| author=DALGAARD OZ| title=Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families. | journal=Acta Med Scand Suppl | year= 1957 | volume= 328 | issue= | pages= 1-255 | pmid=13469269‎ | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13469269 }} </ref>
|-
| bgcolor="#ececec"|'''Germany''' || 1 in 3058 || Neumann et al, 2013<ref name="pmid23300259">{{cite journal| author=Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B et al.| title=Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. | journal=Nephrol Dial Transplant | year= 2013 | volume= 28 | issue= 6 | pages= 1472-87 | pmid=23300259 | doi=10.1093/ndt/gfs551 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23300259 }} </ref>
|-
| bgcolor="#ececec"|'''France''' || 1 in 1111 || Simon et al, 1996<ref name="pmid8838759">{{cite journal| author=Simon P, Le Goff JY, Ang KS, Charasse C, Le Cacheux P, Cam G| title=[Epidemiologic data, clinical and prognostic features of autosomal dominant polycystic kidney disease in a French region]. | journal=Nephrologie | year= 1996 | volume= 17 | issue= 2 | pages= 123-30 | pmid=8838759 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8838759 }} </ref>
|-
| bgcolor="#ececec"|'''United Kingdom''' || 1 in 2459 || Davies et al, 1991<ref name="pmid1946928">{{cite journal| author=Davies F, Coles GA, Harper PS, Williams AJ, Evans C, Cochlin D| title=Polycystic kidney disease re-evaluated: a population-based study. | journal=Q J Med | year= 1991 | volume= 79 | issue= 290 | pages= 477-85 | pmid=1946928 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1946928 }} </ref>
|-
| bgcolor="#ececec"|'''Japan''' || 1 in 4033 || Higashihara et al, 1998<ref name="pmid9832641">{{cite journal| author=Higashihara E, Nutahara K, Kojima M, Tamakoshi A, Yoshiyuki O, Sakai H et al.| title=Prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease in Japan. | journal=Nephron | year= 1998 | volume= 80 | issue= 4 | pages= 421-7 | pmid=9832641 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9832641 }} </ref>
|}


==References==
==References==
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Latest revision as of 23:46, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2], Serge Korjian, Yazan Daaboul

Overview

The prevalence of autosomal dominant polycystic kidney disease (ADPKD) is approximately 100 - 250 per 100,000 individuals in the United States. The prevalence of ADPKD varies in different countries. The prevalence of autosomal recessive polycystic kidney disease (ARPKD) is approximately 5 per 100,000 children in the United States. The incidence increases with age for ADPKD. ARPKD commonly affects infants and children. Males and females are equally affected by ADPKD.

Epidemiology and Demographics

Prevalence

  • The prevalence of autosomal dominant polycystic kidney disease (ADPKD) is approximately 100 - 250 per 100,000 individuals in the United States.[1][2][3]
  • In 2013, the prevalence of autosomal dominant polycystic kidney disease was estimated to be 33 cases per 100,000 individuals in Germany.[4]
  • In 1998, the prevalence of autosomal dominant polycystic kidney disease was estimated to be 25 cases per 100,000 individuals in Japan.[5]
  • In 1996, the prevalence of autosomal dominant polycystic kidney disease was estimated to be 90 cases per 100,000 individuals in France.[6]
  • In 1991, the prevalence of autosomal dominant polycystic kidney disease was estimated to be 41 cases per 100,000 individuals in United Kingdom.[7]
  • In 1957, the prevalence of autosomal dominant polycystic kidney disease was estimated to be 100 cases per 100,000 individuals in Denmark.[8]
  • The prevalence of autosomal recessive polycystic kidney disease (ARPKD) is approximately 5 per 100,000 children in the United States.[9]

Age

  • The incidence of ADPKD increases with age; the average age at diagnosis is 30 - 50 years.[2]
  • ARPKD commonly affects infants and children.[9]

Race

  • There is no racial predilection to autosomal dominant polycystic kidney disease.

Gender

  • Autosomal dominant polycystic kidney disease affects men and women equally.[10]

References

  1. ↑ Iglesias CG, Torres VE, Offord KP, Holley KE, Beard CM, Kurland LT (May 1983). "Epidemiology of adult polycystic kidney disease, Olmsted County, Minnesota: 1935-1980". Am. J. Kidney Dis. 2 (6): 630–9. PMID 6846334.
  2. ↑ 2.0 2.1 Gabow PA (July 1993). "Autosomal dominant polycystic kidney disease". N. Engl. J. Med. 329 (5): 332–42. doi:10.1056/NEJM199307293290508. PMID 8321262.
  3. ↑ Levy M, Feingold J (September 2000). "Estimating prevalence in single-gene kidney diseases progressing to renal failure". Kidney Int. 58 (3): 925–43. doi:10.1046/j.1523-1755.2000.00250.x. PMID 10972657.
  4. ↑ Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B; et al. (2013). "Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany". Nephrol Dial Transplant. 28 (6): 1472–87. doi:10.1093/ndt/gfs551. PMID 23300259.
  5. ↑ Higashihara E, Nutahara K, Kojima M, Tamakoshi A, Yoshiyuki O, Sakai H; et al. (1998). "Prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease in Japan". Nephron. 80 (4): 421–7. PMID 9832641.
  6. ↑ Simon P, Le Goff JY, Ang KS, Charasse C, Le Cacheux P, Cam G (1996). "[Epidemiologic data, clinical and prognostic features of autosomal dominant polycystic kidney disease in a French region]". Nephrologie. 17 (2): 123–30. PMID 8838759.
  7. ↑ Davies F, Coles GA, Harper PS, Williams AJ, Evans C, Cochlin D (1991). "Polycystic kidney disease re-evaluated: a population-based study". Q J Med. 79 (290): 477–85. PMID 1946928.
  8. ↑ DALGAARD OZ (1957). "Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families". Acta Med Scand Suppl. 328: 1–255. PMID 13469269‎ Check |pmid= value (help).
  9. ↑ 9.0 9.1 Guay-Woodford LM, Desmond RA (May 2003). "Autosomal recessive polycystic kidney disease: the clinical experience in North America". Pediatrics. 111 (5 Pt 1): 1072–80. PMID 12728091.
  10. ↑ Torres VE, Harris PC, Pirson Y (2007). "Autosomal dominant polycystic kidney disease". Lancet. 369 (9569): 1287–301. doi:10.1016/S0140-6736(07)60601-1. PMID 17434405.

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