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SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.[1][3]
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Kulkarni AA, Haworth IS, Uchiyama T, Lee VH (2004). "Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis". J. Biol. Chem. 278 (51): 51833–40. doi:10.1074/jbc.M308356200. PMID14532279.
Uchiyama T, Kulkarni AA, Davies DL, Lee VH (2004). "Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1". Pharm. Res. 20 (12): 1911–6. doi:10.1023/B:PHAM.0000008036.05892.e9. PMID14725353.