Parathyroid adenoma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]

Overview

The cause of most parathyroid adenomas is unknown. However, about 10% are said to be hereditary. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene.

Causes

Solitary parathyroid adenoma is the leading cause of primary hyperparathyroidism in 80% to 85% of cases. However, parathyroid adenoma is idiopathic in approximately 90% of the individuals.[1]

Genetic Causes

  • Parathyroid adenoma can be caused by a mutation of the following genes.

References

  1. Duan K, Gomez Hernandez K, Mete O (October 2015). "Clinicopathological correlates of hyperparathyroidism". J. Clin. Pathol. 68 (10): 771–87. doi:10.1136/jclinpath-2015-203186. PMID 26163537.