Parathyroid adenoma causes: Difference between revisions
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{{Parathyroid adenoma}} | {{Parathyroid adenoma}} | ||
{{CMG}}; {{AE}} {{Preeti}} | {{CMG}}; {{AE}} {{Preeti}}, {{Anmol}} | ||
==Overview== | ==Overview== | ||
The cause of most parathyroid adenomas is unknown. However, about 10% are said to be [[hereditary]]. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene. | The cause of most parathyroid adenomas is unknown. However, about 10% are said to be [[hereditary]]. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene. | ||
==Causes== | ==Causes== | ||
Parathyroid adenoma is idiopathic in approximately 90% of the individuals. However, approximately 10% of parathyroid adenoma are caused by mutation in genes.<ref name="pmid26163537">{{cite journal |vauthors=Duan K, Gomez Hernandez K, Mete O |title=Clinicopathological correlates of hyperparathyroidism |journal=J. Clin. Pathol. |volume=68 |issue=10 |pages=771–87 |date=October 2015 |pmid=26163537 |doi=10.1136/jclinpath-2015-203186 |url=}}</ref> | |||
===Genetic Causes=== | ===Genetic Causes=== | ||
Revision as of 13:46, 29 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2], Anmol Pitliya, M.B.B.S. M.D.[3]
Overview
The cause of most parathyroid adenomas is unknown. However, about 10% are said to be hereditary. It can be the result of multiple genetic mutations in genes such as the calcium-sensing receptor gene, HRPT2 gene (CDC73 gene), Cyclin D1 gene (CCND1)/PRAD1 gene, MEN1 gene, and RET gene.
Causes
Parathyroid adenoma is idiopathic in approximately 90% of the individuals. However, approximately 10% of parathyroid adenoma are caused by mutation in genes.[1]
Genetic Causes
- Parathyroid adenoma can be caused by a mutation of the following genes.
- Calcium-sensing receptor gene
- HRPT2 gene (CDC73 gene)
- Cyclin D1 gene (CCND1)/PRAD1 gene
- MEN1 gene
- RET gene
References
- ↑ Duan K, Gomez Hernandez K, Mete O (October 2015). "Clinicopathological correlates of hyperparathyroidism". J. Clin. Pathol. 68 (10): 771–87. doi:10.1136/jclinpath-2015-203186. PMID 26163537.